Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892067833> ?p ?o ?g. }
- W2892067833 endingPage "3688" @default.
- W2892067833 startingPage "3674" @default.
- W2892067833 abstract "Abstract Dysfunctional mitochondria are observed in β-cells of diabetic patients, which are eventually removed by autophagy. Vesicle-associated membrane protein (VAMP)7, a vesicular SNARE protein, regulates autophagosome formation to maintain mitochondrial homeostasis and control insulin secretion in pancreatic β-cells. However, its molecular mechanism is largely unknown. In this study, we investigated the molecular mechanism of VAMP7-dependent autophagosome formation using VAMP7-deficient β-cells and β-cell–derived Min6 cells. VAMP7 localized in autophagy-related (Atg)9a–resident vesicles of recycling endosomes (REs), which contributed to autophagosome formation, and it interacted with Hrb, Syntaxin16, and SNAP-47. Hrb recruited VAMP7 and Atg9a from the plasma membrane to REs. Syntaxin16 and SNAP-47 mediated autophagosome formation at a step later than the proper localization of VAMP7 to Atg9a-resident vesicles. Knockdown of Hrb, Syntaxin16, and SNAP-47 resulted in defective autophagosome formation, accumulation of dysfunctional mitochondria, and impairment of glucose-stimulated insulin secretion. Our data indicate that VAMP7 and Atg9a are initially recruited to REs to organize VAMP7 and Atg9a-resident vesicles in an Hrb-dependent manner. Additionally, VAMP7 forms a SNARE complex with Syntaxin16 and SNAP-47, which may cause fusions of Atg9a-resident vesicles during autophagosome formation. Thus, VAMP7 participates in autophagosome formation by supporting Atg9a functions that contribute to maintenance of mitochondrial quality." @default.
- W2892067833 created "2018-09-27" @default.
- W2892067833 creator A5004364871 @default.
- W2892067833 creator A5021709203 @default.
- W2892067833 creator A5026726273 @default.
- W2892067833 creator A5036849676 @default.
- W2892067833 creator A5037533574 @default.
- W2892067833 creator A5045010984 @default.
- W2892067833 creator A5061420098 @default.
- W2892067833 creator A5063948881 @default.
- W2892067833 creator A5068222821 @default.
- W2892067833 date "2018-09-12" @default.
- W2892067833 modified "2023-10-17" @default.
- W2892067833 title "VAMP7 Regulates Autophagosome Formation by Supporting Atg9a Functions in Pancreatic β-Cells From Male Mice" @default.
- W2892067833 cites W1576633697 @default.
- W2892067833 cites W1839422703 @default.
- W2892067833 cites W1877707875 @default.
- W2892067833 cites W1969756521 @default.
- W2892067833 cites W1974279922 @default.
- W2892067833 cites W1981340241 @default.
- W2892067833 cites W1986303112 @default.
- W2892067833 cites W1986571649 @default.
- W2892067833 cites W1994423882 @default.
- W2892067833 cites W2007202084 @default.
- W2892067833 cites W2012632097 @default.
- W2892067833 cites W2014506057 @default.
- W2892067833 cites W2019341627 @default.
- W2892067833 cites W2019411218 @default.
- W2892067833 cites W2019455536 @default.
- W2892067833 cites W2022570265 @default.
- W2892067833 cites W2025447674 @default.
- W2892067833 cites W2025665129 @default.
- W2892067833 cites W2030287946 @default.
- W2892067833 cites W2032186831 @default.
- W2892067833 cites W2038948722 @default.
- W2892067833 cites W2043062268 @default.
- W2892067833 cites W2046231980 @default.
- W2892067833 cites W2047792293 @default.
- W2892067833 cites W2048451267 @default.
- W2892067833 cites W2052140143 @default.
- W2892067833 cites W2055791664 @default.
- W2892067833 cites W2056478340 @default.
- W2892067833 cites W2056862039 @default.
- W2892067833 cites W2067097574 @default.
- W2892067833 cites W2068700852 @default.
- W2892067833 cites W2077691322 @default.
- W2892067833 cites W2086096948 @default.
- W2892067833 cites W2128970032 @default.
- W2892067833 cites W2132328708 @default.
- W2892067833 cites W2138896791 @default.
- W2892067833 cites W2139801174 @default.
- W2892067833 cites W2152148024 @default.
- W2892067833 cites W2156313819 @default.
- W2892067833 cites W2159640908 @default.
- W2892067833 cites W2170608010 @default.
- W2892067833 cites W2171494754 @default.
- W2892067833 cites W2312373852 @default.
- W2892067833 cites W2325338221 @default.
- W2892067833 cites W2325860767 @default.
- W2892067833 cites W2517043764 @default.
- W2892067833 doi "https://doi.org/10.1210/en.2018-00447" @default.
- W2892067833 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30215699" @default.
- W2892067833 hasPublicationYear "2018" @default.
- W2892067833 type Work @default.
- W2892067833 sameAs 2892067833 @default.
- W2892067833 citedByCount "18" @default.
- W2892067833 countsByYear W28920678332018 @default.
- W2892067833 countsByYear W28920678332019 @default.
- W2892067833 countsByYear W28920678332020 @default.
- W2892067833 countsByYear W28920678332021 @default.
- W2892067833 countsByYear W28920678332022 @default.
- W2892067833 countsByYear W28920678332023 @default.
- W2892067833 crossrefType "journal-article" @default.
- W2892067833 hasAuthorship W2892067833A5004364871 @default.
- W2892067833 hasAuthorship W2892067833A5021709203 @default.
- W2892067833 hasAuthorship W2892067833A5026726273 @default.
- W2892067833 hasAuthorship W2892067833A5036849676 @default.
- W2892067833 hasAuthorship W2892067833A5037533574 @default.
- W2892067833 hasAuthorship W2892067833A5045010984 @default.
- W2892067833 hasAuthorship W2892067833A5061420098 @default.
- W2892067833 hasAuthorship W2892067833A5063948881 @default.
- W2892067833 hasAuthorship W2892067833A5068222821 @default.
- W2892067833 hasBestOaLocation W28920678331 @default.
- W2892067833 hasConcept C102747710 @default.
- W2892067833 hasConcept C130316041 @default.
- W2892067833 hasConcept C168296220 @default.
- W2892067833 hasConcept C185592680 @default.
- W2892067833 hasConcept C190283241 @default.
- W2892067833 hasConcept C203522944 @default.
- W2892067833 hasConcept C41625074 @default.
- W2892067833 hasConcept C55493867 @default.
- W2892067833 hasConcept C79879829 @default.
- W2892067833 hasConcept C86803240 @default.
- W2892067833 hasConcept C95444343 @default.
- W2892067833 hasConceptScore W2892067833C102747710 @default.
- W2892067833 hasConceptScore W2892067833C130316041 @default.
- W2892067833 hasConceptScore W2892067833C168296220 @default.
- W2892067833 hasConceptScore W2892067833C185592680 @default.