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• W2892069746 abstract "Abstract Actinomycetes are a heterogeneous group of gram positive filamentous bacteria that have been found to produce a wide range of valuable bioactive secondary metabolites, particularly antibiotics. Moreover, actinomycetes isolated from unexplored environments show an unprecedented potential to generate novel active compounds. Hence, in order to search for novel antibiotics, we isolated and characterized actinomycetes strains from plant samples collected from a mangrove in Macau. Within the class of actinobacteria, fourteen actinomycetes isolates have been isolated and identified belonging to the genus of Streptomyces , Micromonospora, Mycobacterium, Brevibacterium, Curtobacterium and Kineococcus based on their 16S rRNA sequences. Further whole genome sequencing analysis of one of the isolated Streptomyces sp., which presented 99.13% sequence similarity with Streptomyces parvulus strain 2297, showed that it consisted of 118 scaffolds, 8,348,559 base pairs and had a 72.28% G + C content. In addition, genome-mining revealed that the isolated Streptomyces sp. contains 109 gene clusters responsible for the biosynthesis of known and/or novel secondary metabolites, including different types of terpene, T1pks, T2pks, T3pks, Nrps, indole, siderophore, bacteriocin, thiopeptide, phosphonate, lanthipeptide, ectoine, butyrolactone, T3pks-Nrps, and T1pks-Nrps. Meanwhile, the small molecules present in ethyl acetate extract of the fermentation broth of this strain were analyzed by LC-MS. Predicted secondary metabolites of melanin and desferrioxamine B were identified and both of them were firstly found to be produced by the Streptomyces parvulus strain. Our study highlights that combining genome mining is an efficient method to detect potentially promising natural products from mangrove-derived actinomycetes." @default.
• W2892069746 created "2018-09-27" @default.
• W2892069746 creator A5020031263 @default.
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• W2892069746 date "2018-09-24" @default.
• W2892069746 modified "2023-10-14" @default.
• W2892069746 title "Genome guided investigation of antibiotics producing actinomycetales strain isolated from a Macau mangrove ecosystem" @default.
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• W2892069746 cites W1963506577 @default.
• W2892069746 cites W1966736330 @default.
• W2892069746 cites W1967408138 @default.
• W2892069746 cites W1967745712 @default.
• W2892069746 cites W1973354211 @default.
• W2892069746 cites W1974921094 @default.
• W2892069746 cites W1977050444 @default.
• W2892069746 cites W1985716049 @default.
• W2892069746 cites W1996253845 @default.
• W2892069746 cites W1998113052 @default.
• W2892069746 cites W1998457893 @default.
• W2892069746 cites W2004504499 @default.
• W2892069746 cites W2004775855 @default.
• W2892069746 cites W2004952487 @default.
• W2892069746 cites W2007728391 @default.
• W2892069746 cites W2012960603 @default.
• W2892069746 cites W2026260989 @default.
• W2892069746 cites W2029997716 @default.
• W2892069746 cites W2030709910 @default.
• W2892069746 cites W2032889069 @default.
• W2892069746 cites W2033536968 @default.
• W2892069746 cites W2034643042 @default.
• W2892069746 cites W2044750784 @default.
• W2892069746 cites W2046444093 @default.
• W2892069746 cites W2059279550 @default.
• W2892069746 cites W2060487062 @default.
• W2892069746 cites W2061015842 @default.
• W2892069746 cites W2062464291 @default.
• W2892069746 cites W2063638158 @default.
• W2892069746 cites W2064167559 @default.
• W2892069746 cites W2065933012 @default.
• W2892069746 cites W2066946875 @default.
• W2892069746 cites W2067955209 @default.
• W2892069746 cites W2073430644 @default.
• W2892069746 cites W2074906031 @default.
• W2892069746 cites W2078415854 @default.
• W2892069746 cites W2086102375 @default.
• W2892069746 cites W2089556458 @default.
• W2892069746 cites W2089804615 @default.
• W2892069746 cites W2090367881 @default.
• W2892069746 cites W2104458523 @default.
• W2892069746 cites W2110105875 @default.
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• W2892069746 cites W2141632349 @default.
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• W2892069746 cites W2142077421 @default.
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• W2892069746 cites W2153614246 @default.
• W2892069746 cites W2158817129 @default.
• W2892069746 cites W2163587256 @default.
• W2892069746 cites W2168599417 @default.
• W2892069746 cites W2269978697 @default.
• W2892069746 cites W2312291206 @default.
• W2892069746 cites W2315527456 @default.
• W2892069746 cites W2549129913 @default.
• W2892069746 cites W2564282215 @default.
• W2892069746 cites W2588511283 @default.
• W2892069746 cites W2589898265 @default.
• W2892069746 cites W2604864733 @default.
• W2892069746 cites W2605522513 @default.
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• W2892069746 doi "https://doi.org/10.1038/s41598-018-32076-z" @default.
• W2892069746 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6155160" @default.
• W2892069746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30250135" @default.
• W2892069746 hasPublicationYear "2018" @default.
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