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• W2892071098 abstract "Although debated, metabolic health characterizes 10–25% of obese individuals and reduces risk of developing life-threatening co-morbidities. Adipose tissue is a recognized endocrine organ important for the maintenance of whole-body metabolic health. Adipocyte transcriptional signatures of healthy and unhealthy obesity are largely unknown. Here, we used a small cohort of highly characterized obese individuals discordant for metabolic health, characterized their adipocytes transcriptional signatures, and cross-referenced them to mouse phenotypic and human GWAs databases. Our study showed that glucose intolerance and insulin resistance co-operate to remodel adipocyte transcriptome. We also identified the Nuclear Export Mediator Factor (NEMF) and the Ectoderm-Neural Cortex 1 (ENC1) as novel potential targets in the management of metabolic health in human obesity." @default.
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• W2892071098 date "2018-12-01" @default.
• W2892071098 modified "2023-10-17" @default.
• W2892071098 title "Glucose tolerance and insulin sensitivity define adipocyte transcriptional programs in human obesity" @default.
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• W2892071098 doi "https://doi.org/10.1016/j.molmet.2018.09.004" @default.
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