Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892072295> ?p ?o ?g. }
- W2892072295 endingPage "1276" @default.
- W2892072295 startingPage "1259" @default.
- W2892072295 abstract "Kisspeptin is involved in the control of human reproduction bridging the gap between the sex steroid levels and feedback mechanisms that control the gonadotropin releasing hormone (GnRH) secretion; however, studies considering this peptide and infertility are limited. We conducted a review and critical assessment of available evidence considering kisspeptin structure, physiology, function in puberty and reproduction, its role in assisted reproduction treatments, kisspeptin dosage and the impact on KISS1 and GPR54 genes. Literature searches were conducted in PubMed using keywords related to: (i) kisspeptin or receptors, kisspeptin-1 (ii) reproduction or infertility or fertility (iii) gene and (iv) dosage or measurement or quantification or serum level, in human. Kisspeptin is a product of KISS1 gene that binds to a G-protein-coupled receptor (GPR54/KISS1R) stimulating the release of GnRH by hypothalamic neurons, leading to secretion of pituitary gonadotropins (LH and FSH) and sexual steroids, which in turn will act in the gonads to produce the gametes. Kisspeptin is being recognized as a crucial regulator of the onset of puberty, the regulation of sex hormone mediated secretion of gonadotropins, and the control of fertility. Inactivating and activating mutations in both KISS1 or GPR54 genes were associated with hypogonadotropic hypogonadism and precocious puberty. Despite this, studies considering kisspeptin and infertility are scarce. The understanding of the role of kisspeptin may lead to its use as a biomarker in infertility treatments and use in controlled ovarian hyperstimulation." @default.
- W2892072295 created "2018-09-27" @default.
- W2892072295 creator A5027754051 @default.
- W2892072295 creator A5044787360 @default.
- W2892072295 creator A5046615539 @default.
- W2892072295 creator A5051467144 @default.
- W2892072295 creator A5057445620 @default.
- W2892072295 creator A5079079087 @default.
- W2892072295 creator A5085428723 @default.
- W2892072295 date "2018-01-01" @default.
- W2892072295 modified "2023-10-16" @default.
- W2892072295 title "Kisspeptin/GPR54 System: What Do We Know About Its Role in Human Reproduction?" @default.
- W2892072295 cites W116145509 @default.
- W2892072295 cites W1538938629 @default.
- W2892072295 cites W1702618166 @default.
- W2892072295 cites W1860582902 @default.
- W2892072295 cites W1880891411 @default.
- W2892072295 cites W1898552202 @default.
- W2892072295 cites W1947610607 @default.
- W2892072295 cites W1966519801 @default.
- W2892072295 cites W1977898320 @default.
- W2892072295 cites W1984561810 @default.
- W2892072295 cites W1989716417 @default.
- W2892072295 cites W1995852498 @default.
- W2892072295 cites W1996331981 @default.
- W2892072295 cites W2000496712 @default.
- W2892072295 cites W2006727096 @default.
- W2892072295 cites W2013104189 @default.
- W2892072295 cites W2017208259 @default.
- W2892072295 cites W2028777780 @default.
- W2892072295 cites W2029845917 @default.
- W2892072295 cites W2037420362 @default.
- W2892072295 cites W2038277715 @default.
- W2892072295 cites W2041130371 @default.
- W2892072295 cites W2045690475 @default.
- W2892072295 cites W2046739599 @default.
- W2892072295 cites W2048872158 @default.
- W2892072295 cites W2052757541 @default.
- W2892072295 cites W2058693828 @default.
- W2892072295 cites W2065275835 @default.
- W2892072295 cites W2067130406 @default.
- W2892072295 cites W2068817544 @default.
- W2892072295 cites W2069124690 @default.
- W2892072295 cites W2071573411 @default.
- W2892072295 cites W2073220855 @default.
- W2892072295 cites W2074331251 @default.
- W2892072295 cites W2075326391 @default.
- W2892072295 cites W2075400316 @default.
- W2892072295 cites W2076309282 @default.
- W2892072295 cites W2085857567 @default.
- W2892072295 cites W2089584362 @default.
- W2892072295 cites W2092053353 @default.
- W2892072295 cites W2095439208 @default.
- W2892072295 cites W2100978216 @default.
- W2892072295 cites W2101537436 @default.
- W2892072295 cites W2102850512 @default.
- W2892072295 cites W2103812482 @default.
- W2892072295 cites W2108264404 @default.
- W2892072295 cites W2109672196 @default.
- W2892072295 cites W2111824942 @default.
- W2892072295 cites W2111961504 @default.
- W2892072295 cites W2113860075 @default.
- W2892072295 cites W2114730715 @default.
- W2892072295 cites W2118393218 @default.
- W2892072295 cites W2119156323 @default.
- W2892072295 cites W2119177282 @default.
- W2892072295 cites W2119788961 @default.
- W2892072295 cites W2120568375 @default.
- W2892072295 cites W2128836311 @default.
- W2892072295 cites W2135815198 @default.
- W2892072295 cites W2142686356 @default.
- W2892072295 cites W2143506157 @default.
- W2892072295 cites W2151613225 @default.
- W2892072295 cites W2155941020 @default.
- W2892072295 cites W2158795213 @default.
- W2892072295 cites W2159296536 @default.
- W2892072295 cites W2159795181 @default.
- W2892072295 cites W2161155942 @default.
- W2892072295 cites W2170518484 @default.
- W2892072295 cites W2171036048 @default.
- W2892072295 cites W2171193387 @default.
- W2892072295 cites W2171517203 @default.
- W2892072295 cites W2175995937 @default.
- W2892072295 cites W2180910024 @default.
- W2892072295 cites W2181342406 @default.
- W2892072295 cites W2195338808 @default.
- W2892072295 cites W2256080802 @default.
- W2892072295 cites W2412987961 @default.
- W2892072295 cites W2505262027 @default.
- W2892072295 cites W2514880042 @default.
- W2892072295 cites W2521583590 @default.
- W2892072295 cites W2534534507 @default.
- W2892072295 cites W2552927675 @default.
- W2892072295 cites W2591715067 @default.
- W2892072295 cites W2666399940 @default.
- W2892072295 cites W2689118140 @default.
- W2892072295 cites W2737577525 @default.
- W2892072295 cites W2742961051 @default.