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- W2892072902 abstract "AEOL-10150 is a broad-spectrum metalloporphyrin superoxidase dismutase (SOD) mimic specifically designed to neutralize reactive oxygen and nitrogen species. Research has shown that AEOL-10150 is a potent medical countermeasure against national security threats including sulfur mustard (SM), nerve agent exposure and radiation pneumonitis following a radiological/nuclear incident sufficient to cause acute radiation syndrome (ARS). AEOL-10150 performed well in animal safety studies, and two completed phase 1 safety studies in patients demonstrated that the drug was safe and well tolerated, indicating that AEOL-10150 has potential as a new catalytic antioxidant drug. In this article, we review improvements in AEOL-10150 in preclinical pharmacodynamic studies, especially regarding anti-SM, chlorine gas and radiation exposure studies." @default.
- W2892072902 created "2018-09-27" @default.
- W2892072902 creator A5030223638 @default.
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- W2892072902 date "2018-09-06" @default.
- W2892072902 modified "2023-10-17" @default.
- W2892072902 title "Improvements in SOD mimic AEOL-10150, a potent broad-spectrum antioxidant" @default.
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- W2892072902 doi "https://doi.org/10.1186/s40779-018-0176-3" @default.
- W2892072902 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6125955" @default.
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