Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892073971> ?p ?o ?g. }
- W2892073971 endingPage "126" @default.
- W2892073971 startingPage "118" @default.
- W2892073971 abstract "Ghrelin, a peptide hormone produced in the gastrointestinal tract, has recently been found to be associated with the onset of myocardial fibrosis (MF). The exact mechanism, however, remains elusive. This study sought to identify the function and mechanism of ghrelin on MF after acute myocardial infarction (AMI). AMI was established in Spraque-Dawley rats by ligation of the left anterior descending (LAD). Ghrelin or saline was intraperitoneally injected two times per day for 8 weeks after ligation. The weight of heart (mg) and the weight ratio of heart to body (mg/g) as well as the fibrotic area were increased, while serum level of ghrelin was decreased after AMI. Ghrelin significantly ameliorated MF and decreased deposition of collagens in perivascular fibrosis area. In addition, ghrelin inhibited Endothelial-to-mesenchymal transition (EndMT), a crucial process for MF, in perivascular fibrosis area and TGF-β1-induced human coronary artery endothelial cells (HCAECs). Mechanistically, ghrelin persistently decreased the phosphorylation of Smad2/3 and enhanced the expression of Smad7 and p-AMPK in vivo and in vitro. After the abolition of Smad7, GHSR-1a and AMPK pathway, the effect of ghrelin on EndMT was significantly inhibited. In conclusion, these results presented a novel finding that ghrelin attenuated MF after AMI via regulation EndMT in a GHSR-1a/AMPK/Smad7- dependent manner." @default.
- W2892073971 created "2018-09-27" @default.
- W2892073971 creator A5000142295 @default.
- W2892073971 creator A5004088623 @default.
- W2892073971 creator A5009757097 @default.
- W2892073971 creator A5014402190 @default.
- W2892073971 creator A5017940926 @default.
- W2892073971 creator A5023378337 @default.
- W2892073971 creator A5027750584 @default.
- W2892073971 creator A5042882543 @default.
- W2892073971 creator A5047580399 @default.
- W2892073971 creator A5052872593 @default.
- W2892073971 creator A5082645537 @default.
- W2892073971 creator A5083852203 @default.
- W2892073971 creator A5085169109 @default.
- W2892073971 date "2019-01-01" @default.
- W2892073971 modified "2023-10-02" @default.
- W2892073971 title "Ghrelin attenuates myocardial fibrosis after acute myocardial infarction via inhibiting endothelial-to mesenchymal transition in rat model" @default.
- W2892073971 cites W1135082898 @default.
- W2892073971 cites W1519230909 @default.
- W2892073971 cites W1968625886 @default.
- W2892073971 cites W1968879866 @default.
- W2892073971 cites W1979517142 @default.
- W2892073971 cites W1981927821 @default.
- W2892073971 cites W1985650502 @default.
- W2892073971 cites W2019912965 @default.
- W2892073971 cites W2031137884 @default.
- W2892073971 cites W2032287280 @default.
- W2892073971 cites W2035600501 @default.
- W2892073971 cites W2039006670 @default.
- W2892073971 cites W2044663433 @default.
- W2892073971 cites W2072056597 @default.
- W2892073971 cites W2075120995 @default.
- W2892073971 cites W2077997754 @default.
- W2892073971 cites W2104986283 @default.
- W2892073971 cites W2111250483 @default.
- W2892073971 cites W2126941823 @default.
- W2892073971 cites W2130906765 @default.
- W2892073971 cites W2131977410 @default.
- W2892073971 cites W2132250523 @default.
- W2892073971 cites W2136027419 @default.
- W2892073971 cites W2139789471 @default.
- W2892073971 cites W2142613844 @default.
- W2892073971 cites W2161918376 @default.
- W2892073971 cites W2299099463 @default.
- W2892073971 cites W2336395638 @default.
- W2892073971 cites W2340327383 @default.
- W2892073971 cites W2342679639 @default.
- W2892073971 cites W2462416197 @default.
- W2892073971 cites W2465126283 @default.
- W2892073971 cites W2484771491 @default.
- W2892073971 cites W2502359570 @default.
- W2892073971 cites W2586145823 @default.
- W2892073971 cites W2595348957 @default.
- W2892073971 cites W2595990160 @default.
- W2892073971 cites W2605959934 @default.
- W2892073971 cites W2607227786 @default.
- W2892073971 cites W2765592896 @default.
- W2892073971 cites W4211143906 @default.
- W2892073971 doi "https://doi.org/10.1016/j.peptides.2018.09.001" @default.
- W2892073971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30218693" @default.
- W2892073971 hasPublicationYear "2019" @default.
- W2892073971 type Work @default.
- W2892073971 sameAs 2892073971 @default.
- W2892073971 citedByCount "12" @default.
- W2892073971 countsByYear W28920739712020 @default.
- W2892073971 countsByYear W28920739712021 @default.
- W2892073971 countsByYear W28920739712022 @default.
- W2892073971 countsByYear W28920739712023 @default.
- W2892073971 crossrefType "journal-article" @default.
- W2892073971 hasAuthorship W2892073971A5000142295 @default.
- W2892073971 hasAuthorship W2892073971A5004088623 @default.
- W2892073971 hasAuthorship W2892073971A5009757097 @default.
- W2892073971 hasAuthorship W2892073971A5014402190 @default.
- W2892073971 hasAuthorship W2892073971A5017940926 @default.
- W2892073971 hasAuthorship W2892073971A5023378337 @default.
- W2892073971 hasAuthorship W2892073971A5027750584 @default.
- W2892073971 hasAuthorship W2892073971A5042882543 @default.
- W2892073971 hasAuthorship W2892073971A5047580399 @default.
- W2892073971 hasAuthorship W2892073971A5052872593 @default.
- W2892073971 hasAuthorship W2892073971A5082645537 @default.
- W2892073971 hasAuthorship W2892073971A5083852203 @default.
- W2892073971 hasAuthorship W2892073971A5085169109 @default.
- W2892073971 hasConcept C11960822 @default.
- W2892073971 hasConcept C126322002 @default.
- W2892073971 hasConcept C134018914 @default.
- W2892073971 hasConcept C150903083 @default.
- W2892073971 hasConcept C179437574 @default.
- W2892073971 hasConcept C185592680 @default.
- W2892073971 hasConcept C207001950 @default.
- W2892073971 hasConcept C2779357093 @default.
- W2892073971 hasConcept C2780124434 @default.
- W2892073971 hasConcept C2780559512 @default.
- W2892073971 hasConcept C3018763269 @default.
- W2892073971 hasConcept C500558357 @default.
- W2892073971 hasConcept C55493867 @default.
- W2892073971 hasConcept C71315377 @default.
- W2892073971 hasConcept C71924100 @default.