FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892074406> ?p ?o ?g. }

• W2892074406 endingPage "2809" @default.
• W2892074406 startingPage "2809" @default.
• W2892074406 abstract "Gut dysbiosis is associated with colitis-associated colorectal carcinogenesis, and the genetic deficiency of the Muc2 gene causes spontaneous development of colitis and colorectal cancer. Whether there are changes of gut microbiota and a linkage between the changes of microbiota and intestinal pathology in Muc2−/− mice are unclear. Muc2−/− and Muc2+/+ mice were generated by backcrossing from Muc2+/− mice, and the fecal samples were collected at different dates (48th, 98th, 118th, 138th, and 178th day). Gut microbiota were analyzed by high-throughput sequencing with the universal 16S rRNA primers (V3–V5 region). All mice were sacrificed at day 178 to collect colonic tissue and epithelial cells for the analysis of histopathology and inflammatory cytokines. On the 178th day, Muc2−/− mice developed colorectal chronic colitis, hyperplasia, adenomas and adenocarcinomas, and inflammatory cytokines (e.g., cyclooxygenase 2 (COX-2), interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin 1 β (IL-1β), i-kappa-B-kinase β (IKKβ)) were significantly increased in colonic epithelial cells of Muc2−/− mice. In general, structural segregation of gut microbiota was observed throughout the experimental time points between the Muc2−/− and Muc2+/+ mice. Impressively, in Muc2−/− mice, Alpha diversities reflected by Shannon and Chao indexes were higher, the phylum of Firmicutes was enriched and Bacteroidetes was decreased, and Desulfovibrio, Escherichia, Akkermansia, Turicibacter, and Erysipelotrichaceae were significantly increased, but Lactobacilli and Lachnospiraceae were significantly decreased. Moreover, the abundance of Ruminococcaceae and butyrate-producing bacteria was significantly higher in the Muc2−/− mice. There were significant differences of gut microbiota between Muc2−/− and Muc2+/+ mice. The dynamic changes of microbiota might contribute to the development of colitis and colitis-associated colorectal carcinogenesis. Therefore, this study revealed specific functional bacteria in the development of colitis and colitis-associated colorectal carcinogenesis, which will benefit the development of preventive and therapeutic strategies for chronic inflammation and its malignant transformation." @default.
• W2892074406 created "2018-09-27" @default.
• W2892074406 creator A5003721215 @default.
• W2892074406 creator A5026820294 @default.
• W2892074406 creator A5034054749 @default.
• W2892074406 creator A5048565157 @default.
• W2892074406 creator A5056812893 @default.
• W2892074406 creator A5074110801 @default.
• W2892074406 date "2018-09-18" @default.
• W2892074406 modified "2023-10-04" @default.
• W2892074406 title "The Dynamic Changes of Gut Microbiota in Muc2 Deficient Mice" @default.
• W2892074406 cites W1810335376 @default.
• W2892074406 cites W1934624334 @default.
• W2892074406 cites W1971452287 @default.
• W2892074406 cites W1978709058 @default.
• W2892074406 cites W1979992629 @default.
• W2892074406 cites W1986406665 @default.
• W2892074406 cites W2003269843 @default.
• W2892074406 cites W2003412530 @default.
• W2892074406 cites W2003950107 @default.
• W2892074406 cites W2012704091 @default.
• W2892074406 cites W2015567271 @default.
• W2892074406 cites W2016853666 @default.
• W2892074406 cites W2018120323 @default.
• W2892074406 cites W2018620221 @default.
• W2892074406 cites W2020597244 @default.
• W2892074406 cites W2029705820 @default.
• W2892074406 cites W2032382941 @default.
• W2892074406 cites W2043593402 @default.
• W2892074406 cites W2062280617 @default.
• W2892074406 cites W2069507800 @default.
• W2892074406 cites W2073217065 @default.
• W2892074406 cites W2080598921 @default.
• W2892074406 cites W2089643849 @default.
• W2892074406 cites W2101434677 @default.
• W2892074406 cites W2115450300 @default.
• W2892074406 cites W2125932918 @default.
• W2892074406 cites W2133856765 @default.
• W2892074406 cites W2143841612 @default.
• W2892074406 cites W2154896150 @default.
• W2892074406 cites W2159172903 @default.
• W2892074406 cites W2161548174 @default.
• W2892074406 cites W2163334794 @default.
• W2892074406 cites W2231413477 @default.
• W2892074406 cites W2235523093 @default.
• W2892074406 cites W2260581499 @default.
• W2892074406 cites W2307660471 @default.
• W2892074406 cites W2331748983 @default.
• W2892074406 cites W2404101934 @default.
• W2892074406 cites W2427089839 @default.
• W2892074406 cites W2464441572 @default.
• W2892074406 cites W2553776454 @default.
• W2892074406 cites W2556082987 @default.
• W2892074406 cites W2556950455 @default.
• W2892074406 cites W2560809255 @default.
• W2892074406 cites W2576991729 @default.
• W2892074406 cites W2596103622 @default.
• W2892074406 cites W2611882427 @default.
• W2892074406 cites W2767875510 @default.
• W2892074406 cites W2772557707 @default.
• W2892074406 cites W2790781105 @default.
• W2892074406 doi "https://doi.org/10.3390/ijms19092809" @default.
• W2892074406 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6164417" @default.
• W2892074406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30231491" @default.
• W2892074406 hasPublicationYear "2018" @default.
• W2892074406 type Work @default.
• W2892074406 sameAs 2892074406 @default.
• W2892074406 citedByCount "76" @default.
• W2892074406 countsByYear W28920744062019 @default.
• W2892074406 countsByYear W28920744062020 @default.
• W2892074406 countsByYear W28920744062021 @default.
• W2892074406 countsByYear W28920744062022 @default.
• W2892074406 countsByYear W28920744062023 @default.
• W2892074406 crossrefType "journal-article" @default.
• W2892074406 hasAuthorship W2892074406A5003721215 @default.
• W2892074406 hasAuthorship W2892074406A5026820294 @default.
• W2892074406 hasAuthorship W2892074406A5034054749 @default.
• W2892074406 hasAuthorship W2892074406A5048565157 @default.
• W2892074406 hasAuthorship W2892074406A5056812893 @default.
• W2892074406 hasAuthorship W2892074406A5074110801 @default.
• W2892074406 hasBestOaLocation W28920744061 @default.
• W2892074406 hasConcept C104317684 @default.
• W2892074406 hasConcept C150194340 @default.
• W2892074406 hasConcept C203014093 @default.
• W2892074406 hasConcept C2775862500 @default.
• W2892074406 hasConcept C2776109033 @default.
• W2892074406 hasConcept C2777116383 @default.
• W2892074406 hasConcept C2777695942 @default.
• W2892074406 hasConcept C2778168646 @default.
• W2892074406 hasConcept C2779704485 @default.
• W2892074406 hasConcept C42062724 @default.
• W2892074406 hasConcept C523546767 @default.
• W2892074406 hasConcept C539455810 @default.
• W2892074406 hasConcept C54355233 @default.
• W2892074406 hasConcept C86803240 @default.
• W2892074406 hasConceptScore W2892074406C104317684 @default.
• W2892074406 hasConceptScore W2892074406C150194340 @default.
• W2892074406 hasConceptScore W2892074406C203014093 @default.

• next