Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892078412> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2892078412 abstract "Background: Donor-derived cell free DNA (ddcf DNA) has been reported as a universal noninvasive biomarker for rejection monitoring in heart, kidney, liver, and lung transplantation. Current approaches based on next-generation sequencing for quantification of ddcf DNA, although promising, may be restricted by the requirement for donor material, as donor samples may not be available. Methods: We proposed a novel next-generation sequencing approach without donor-derived material and compared the non-donor-derived approach and the donor-derived approach using simulation testing and 69 clinical specimens. We also evaluated the performance for acute rejection and infection monitoring in lung transplantation. Results: The non-donor-derived approach reached similar efficacy as the donor-derived approach with a significant linear correlation of R2 = 0.98. Subsequent validation in clinical specimens demonstrated significant difference between the acute rejection group (4.83% ± 2.11%, mean ± SD) and the non-rejection group (1.61% ± 0.63%, mean ± SD) (P < 0.0001, Welch’s t test). With the cut-off value of 2.999, our approach had 90.48% sensitivity (95% CI, 69.62% - 98.83%), 100% specificity (95% CI, 91.59% - 100%), and AUC 0.9266 (95% CI, 0.8277 - 1.026). The test also had the ability to simultaneously detect infectious agents, especially cytomegalovirus, as compared with the clinical test. Conclusion: The proposed approach without donor-derived material could potentially be used to monitor acute rejection and infection in lung transplantation and may be applied to other types of solid organ transplantation." @default.
- W2892078412 created "2018-09-27" @default.
- W2892078412 creator A5004131052 @default.
- W2892078412 creator A5021809579 @default.
- W2892078412 creator A5024366880 @default.
- W2892078412 creator A5031255136 @default.
- W2892078412 creator A5032764121 @default.
- W2892078412 creator A5037703362 @default.
- W2892078412 creator A5041001914 @default.
- W2892078412 creator A5053709713 @default.
- W2892078412 creator A5056813625 @default.
- W2892078412 creator A5072803823 @default.
- W2892078412 creator A5072852377 @default.
- W2892078412 creator A5074301456 @default.
- W2892078412 creator A5074447759 @default.
- W2892078412 creator A5078245243 @default.
- W2892078412 creator A5079524009 @default.
- W2892078412 creator A5080451542 @default.
- W2892078412 creator A5084681373 @default.
- W2892078412 creator A5085935898 @default.
- W2892078412 date "2018-01-01" @default.
- W2892078412 modified "2023-10-01" @default.
- W2892078412 title "A Novel Next-Generation Sequencing Approach without Donor-Derived Material for Acute Rejection and Infection Monitoring in Solid Organ Transplantation" @default.
- W2892078412 doi "https://doi.org/10.4236/jct.2018.99054" @default.
- W2892078412 hasPublicationYear "2018" @default.
- W2892078412 type Work @default.
- W2892078412 sameAs 2892078412 @default.
- W2892078412 citedByCount "1" @default.
- W2892078412 countsByYear W28920784122020 @default.
- W2892078412 crossrefType "journal-article" @default.
- W2892078412 hasAuthorship W2892078412A5004131052 @default.
- W2892078412 hasAuthorship W2892078412A5021809579 @default.
- W2892078412 hasAuthorship W2892078412A5024366880 @default.
- W2892078412 hasAuthorship W2892078412A5031255136 @default.
- W2892078412 hasAuthorship W2892078412A5032764121 @default.
- W2892078412 hasAuthorship W2892078412A5037703362 @default.
- W2892078412 hasAuthorship W2892078412A5041001914 @default.
- W2892078412 hasAuthorship W2892078412A5053709713 @default.
- W2892078412 hasAuthorship W2892078412A5056813625 @default.
- W2892078412 hasAuthorship W2892078412A5072803823 @default.
- W2892078412 hasAuthorship W2892078412A5072852377 @default.
- W2892078412 hasAuthorship W2892078412A5074301456 @default.
- W2892078412 hasAuthorship W2892078412A5074447759 @default.
- W2892078412 hasAuthorship W2892078412A5078245243 @default.
- W2892078412 hasAuthorship W2892078412A5079524009 @default.
- W2892078412 hasAuthorship W2892078412A5080451542 @default.
- W2892078412 hasAuthorship W2892078412A5084681373 @default.
- W2892078412 hasAuthorship W2892078412A5085935898 @default.
- W2892078412 hasBestOaLocation W28920784121 @default.
- W2892078412 hasConcept C126322002 @default.
- W2892078412 hasConcept C2780303639 @default.
- W2892078412 hasConcept C2781197716 @default.
- W2892078412 hasConcept C2781448352 @default.
- W2892078412 hasConcept C2911091166 @default.
- W2892078412 hasConcept C55493867 @default.
- W2892078412 hasConcept C71924100 @default.
- W2892078412 hasConcept C86803240 @default.
- W2892078412 hasConceptScore W2892078412C126322002 @default.
- W2892078412 hasConceptScore W2892078412C2780303639 @default.
- W2892078412 hasConceptScore W2892078412C2781197716 @default.
- W2892078412 hasConceptScore W2892078412C2781448352 @default.
- W2892078412 hasConceptScore W2892078412C2911091166 @default.
- W2892078412 hasConceptScore W2892078412C55493867 @default.
- W2892078412 hasConceptScore W2892078412C71924100 @default.
- W2892078412 hasConceptScore W2892078412C86803240 @default.
- W2892078412 hasLocation W28920784121 @default.
- W2892078412 hasOpenAccess W2892078412 @default.
- W2892078412 hasPrimaryLocation W28920784121 @default.
- W2892078412 hasRelatedWork W1859632889 @default.
- W2892078412 hasRelatedWork W2024692616 @default.
- W2892078412 hasRelatedWork W2039812990 @default.
- W2892078412 hasRelatedWork W2060623990 @default.
- W2892078412 hasRelatedWork W2138053774 @default.
- W2892078412 hasRelatedWork W2234391961 @default.
- W2892078412 hasRelatedWork W2522725979 @default.
- W2892078412 hasRelatedWork W2795069241 @default.
- W2892078412 hasRelatedWork W2914987651 @default.
- W2892078412 hasRelatedWork W2945557230 @default.
- W2892078412 hasRelatedWork W2948070222 @default.
- W2892078412 hasRelatedWork W2965408847 @default.
- W2892078412 hasRelatedWork W2995679738 @default.
- W2892078412 hasRelatedWork W3025446704 @default.
- W2892078412 hasRelatedWork W3033878190 @default.
- W2892078412 hasRelatedWork W3111629574 @default.
- W2892078412 hasRelatedWork W3152545247 @default.
- W2892078412 hasRelatedWork W3158352244 @default.
- W2892078412 hasRelatedWork W3193696325 @default.
- W2892078412 hasRelatedWork W3055241107 @default.
- W2892078412 isParatext "false" @default.
- W2892078412 isRetracted "false" @default.
- W2892078412 magId "2892078412" @default.
- W2892078412 workType "article" @default.