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• W2892079174 abstract "Overall survival for the high-risk group of neuroblastoma (NB) patients still remains at 40-50%, necessitating the establishment of a curable treatment. LIM domain only 1 (LMO1) gene encoding a transcriptional regulator is an NB-susceptibility gene with a tumor-promoting activity. Previously we conducted chromatin immunoprecipitation and DNA sequencing analyses on NB cell lines and identified 3 protein-coding genes regulated by LMO1. In this study, we extended our analyses to capture microRNA genes directly or indirectly regulated by LMO1.Using microarrays, we conducted a comparative gene expression analysis on an NB cell line SK-N-SH; between the cells with and without LMO1 suppression.Overall, 18 microRNAs were identified to be indirectly down-regulated by LMO1 including 7 microRNAs of the let-7 family, whose cell proliferation inhibitory activity was observed.Target genes of the LMO1-regulated microRNAs and their relevant pathways may be a potential therapeutic target." @default.
• W2892079174 created "2018-09-27" @default.
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• W2892079174 date "2018-01-01" @default.
• W2892079174 modified "2023-10-09" @default.
• W2892079174 title "Indirect Down-regulation of Tumor-suppressive let-7 Family MicroRNAs by LMO1 in Neuroblastoma" @default.
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• W2892079174 doi "https://doi.org/10.21873/cgp.20100" @default.
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