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• W2892080000 endingPage "768" @default.
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• W2892080000 abstract "Dental caries, starting from demineralization of enamel and dentine, is closely related with acid-producing bacteria in oral cavity, for example, Streptococcus mutans. Remineralization is an efficient way to prevent the disease progression and facilitate the therapy of incipient caries. Therefore, for the purpose of effective dentine repair, remineralization and antibacterial should be combined simultaneously. However, most of the literatures only focus on one single aspect, while combing remineralization and antibacteria for dentine repair in one system is rarely reported. Here in this work, phosphoryl-terminated poly(amide-amine) dendrimers were loaded with apigenin, a water-nonsoluble drug antibacterial agains Streptococcus mutans. The apigenin-loaded dendrimers bind strongly with dentine, which further induce dentine tubules occlusion through mineralization in artificial saliva, and the release of apigenin can prevent further erosion of dentine by bacteria. Meanwhile, the phosphorylated dendrimers are easily prepared by one-step modification of poly(amide-amine) and exhibit good cytocompatibility. This strategy developed here can provide reference for the design of effective anti-caries materials." @default.
• W2892080000 created "2018-09-27" @default.
• W2892080000 creator A5014014148 @default.
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• W2892080000 date "2018-12-01" @default.
• W2892080000 modified "2023-10-14" @default.
• W2892080000 title "One-step phosphorylated poly(amide-amine) dendrimer loaded with apigenin for simultaneous remineralization and antibacterial of dentine" @default.
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• W2892080000 doi "https://doi.org/10.1016/j.colsurfb.2018.09.036" @default.
• W2892080000 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30261466" @default.
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