Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892080361> ?p ?o ?g. }
- W2892080361 endingPage "e0204229" @default.
- W2892080361 startingPage "e0204229" @default.
- W2892080361 abstract "Innate immune cells, such as macrophages, respond to pathogen-associated molecular patterns, such as a lipopolysaccharide (LPS), to secrete various inflammatory mediators. Recent studies have suggested that damage-associated molecular patterns (DAMPs), released extracellularly from damaged or immune cells, also play a role in the activation of inflammatory responses. In this study, to prevent excess inflammation, we focused on DAMPs-mediated signaling that promotes LPS-stimulated inflammatory responses, especially adenosine 5’-triphosphate (ATP)-triggered signaling through the ionotropic purinergic receptor 7 (P2X7R), as a potential new anti-inflammatory target of natural polyphenols. We focused on the phenomenon that ATP accelerates the production of inflammatory mediators, such as nitric oxide, in LPS-stimulated J774.1 mouse macrophages. Using an siRNA-mediated knockdown and specific antagonist, it was found that the ATP-induced enhanced inflammatory responses were mediated through P2X7R. We then screened 42 polyphenols for inhibiting the ATP/P2X7R-induced calcium influx, and found that several polyphenols exhibited significant inhibitory effects. Especially, a flavonoid baicalein significantly inhibited ATP-induced inflammation, including interleukin-1β secretion, through inhibition of the ATP/P2X7R signaling. These findings suggest that ATP/P2X7R signaling plays an important role in excess inflammatory responses and could be a potential anti-inflammatory target of natural polyphenolic compounds." @default.
- W2892080361 created "2018-09-27" @default.
- W2892080361 creator A5015427304 @default.
- W2892080361 creator A5064446971 @default.
- W2892080361 creator A5069932874 @default.
- W2892080361 creator A5080565657 @default.
- W2892080361 date "2018-09-24" @default.
- W2892080361 modified "2023-10-17" @default.
- W2892080361 title "ATP/P2X7 receptor signaling as a potential anti-inflammatory target of natural polyphenols" @default.
- W2892080361 cites W1560571961 @default.
- W2892080361 cites W1615432648 @default.
- W2892080361 cites W1778232194 @default.
- W2892080361 cites W1897243328 @default.
- W2892080361 cites W1899027652 @default.
- W2892080361 cites W1930908839 @default.
- W2892080361 cites W1965130745 @default.
- W2892080361 cites W1967805987 @default.
- W2892080361 cites W1970033359 @default.
- W2892080361 cites W1971620051 @default.
- W2892080361 cites W1975388752 @default.
- W2892080361 cites W1983419107 @default.
- W2892080361 cites W1985948706 @default.
- W2892080361 cites W1989038593 @default.
- W2892080361 cites W1991047945 @default.
- W2892080361 cites W2003547729 @default.
- W2892080361 cites W2006049488 @default.
- W2892080361 cites W2006287956 @default.
- W2892080361 cites W2007706680 @default.
- W2892080361 cites W2007808963 @default.
- W2892080361 cites W2010480763 @default.
- W2892080361 cites W2020618233 @default.
- W2892080361 cites W2024405339 @default.
- W2892080361 cites W2025896000 @default.
- W2892080361 cites W2026497490 @default.
- W2892080361 cites W2028427708 @default.
- W2892080361 cites W2029102160 @default.
- W2892080361 cites W2030182341 @default.
- W2892080361 cites W2031084334 @default.
- W2892080361 cites W2031814313 @default.
- W2892080361 cites W2034643457 @default.
- W2892080361 cites W2039231261 @default.
- W2892080361 cites W2042851093 @default.
- W2892080361 cites W2042906495 @default.
- W2892080361 cites W2050283646 @default.
- W2892080361 cites W2057224622 @default.
- W2892080361 cites W2058957274 @default.
- W2892080361 cites W2062835892 @default.
- W2892080361 cites W2063273780 @default.
- W2892080361 cites W2065794552 @default.
- W2892080361 cites W2066963386 @default.
- W2892080361 cites W2068897578 @default.
- W2892080361 cites W2072321567 @default.
- W2892080361 cites W2073679813 @default.
- W2892080361 cites W2077039193 @default.
- W2892080361 cites W2079158266 @default.
- W2892080361 cites W2085083148 @default.
- W2892080361 cites W2085380620 @default.
- W2892080361 cites W2086556660 @default.
- W2892080361 cites W2086809028 @default.
- W2892080361 cites W2093037778 @default.
- W2892080361 cites W2095795382 @default.
- W2892080361 cites W2096539359 @default.
- W2892080361 cites W2096979751 @default.
- W2892080361 cites W2099719313 @default.
- W2892080361 cites W2099757747 @default.
- W2892080361 cites W2109491705 @default.
- W2892080361 cites W2113290395 @default.
- W2892080361 cites W2117133437 @default.
- W2892080361 cites W2118278569 @default.
- W2892080361 cites W2119734216 @default.
- W2892080361 cites W2128767149 @default.
- W2892080361 cites W2132475539 @default.
- W2892080361 cites W2132959555 @default.
- W2892080361 cites W2135004245 @default.
- W2892080361 cites W2135325091 @default.
- W2892080361 cites W2137500094 @default.
- W2892080361 cites W2143383253 @default.
- W2892080361 cites W2144195410 @default.
- W2892080361 cites W2145676965 @default.
- W2892080361 cites W2150367899 @default.
- W2892080361 cites W2155706758 @default.
- W2892080361 cites W2159087408 @default.
- W2892080361 cites W2167080149 @default.
- W2892080361 cites W2167645193 @default.
- W2892080361 cites W2170688086 @default.
- W2892080361 cites W2193158796 @default.
- W2892080361 cites W2222487181 @default.
- W2892080361 cites W2292051166 @default.
- W2892080361 cites W2589764628 @default.
- W2892080361 cites W2597076579 @default.
- W2892080361 cites W2603205880 @default.
- W2892080361 cites W2603350173 @default.
- W2892080361 cites W4294183732 @default.
- W2892080361 doi "https://doi.org/10.1371/journal.pone.0204229" @default.
- W2892080361 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6152980" @default.
- W2892080361 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30248132" @default.
- W2892080361 hasPublicationYear "2018" @default.
- W2892080361 type Work @default.