Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892081182> ?p ?o ?g. }
- W2892081182 endingPage "6809" @default.
- W2892081182 startingPage "6803" @default.
- W2892081182 abstract "Porcine epidemic diarrhea virus (PEDV) infects pigs of all ages by invading villous epithelial cells of the small intestine causing severe diarrhea with high mortality rate in suckling piglets. Mucosal immunity is believed to play an important role in PEDV control and mucosal delivery of vaccines induces mucosal immunity more efficiently than parenteral vaccination. In this study, coated PEDV-loaded microspheres with the size range of 700–900 μm in diameter were developed by centrifugal granulation-fluidized bed coating and demonstrated as an effective oral delivery system to protect PEDV antigens against the complex gastrointestinal environment by detecting the live virus particles in microspheres after the simulated gastric fluid treatment and the PEDV RNA in fecal swabs collected from all weaned piglets (100%) orally inoculated with coated PEDV-loaded microspheres. Weaned piglets orally immunized with coated PEDV-loaded microspheres developed higher levels of PEDV-specific antibodies (IgG and IgA) in their sera and saliva than those negative control groups (p < 0.001 or p < 0.01). Furthermore, neutralization assays demonstrated that serum antibodies in coated PEDV-loaded microspheres groups could significantly inhibit virus infection in Vero cells, compared to PEDV only group (p < 0.05). Overall, our results indicate that the coated PEDV-loaded microspheres might serve as an effective way to induce PEDV-specific mucosal immunity in pigs against PEDV." @default.
- W2892081182 created "2018-09-27" @default.
- W2892081182 creator A5000432967 @default.
- W2892081182 creator A5000605053 @default.
- W2892081182 creator A5013752180 @default.
- W2892081182 creator A5016759484 @default.
- W2892081182 creator A5023874610 @default.
- W2892081182 creator A5036548928 @default.
- W2892081182 creator A5037989560 @default.
- W2892081182 creator A5059797825 @default.
- W2892081182 creator A5065968878 @default.
- W2892081182 creator A5067307509 @default.
- W2892081182 date "2018-10-01" @default.
- W2892081182 modified "2023-10-02" @default.
- W2892081182 title "Oral administration of coated PEDV-loaded microspheres elicited PEDV-specific immunity in weaned piglets" @default.
- W2892081182 cites W1948873942 @default.
- W2892081182 cites W1968233779 @default.
- W2892081182 cites W1982727736 @default.
- W2892081182 cites W1983212789 @default.
- W2892081182 cites W1985090701 @default.
- W2892081182 cites W1998067471 @default.
- W2892081182 cites W2006886853 @default.
- W2892081182 cites W2012097206 @default.
- W2892081182 cites W2015663648 @default.
- W2892081182 cites W2034041655 @default.
- W2892081182 cites W2042157784 @default.
- W2892081182 cites W2044216286 @default.
- W2892081182 cites W2047529506 @default.
- W2892081182 cites W2060226001 @default.
- W2892081182 cites W2062874583 @default.
- W2892081182 cites W2070315095 @default.
- W2892081182 cites W2094023848 @default.
- W2892081182 cites W2102974062 @default.
- W2892081182 cites W2143817879 @default.
- W2892081182 cites W2166880388 @default.
- W2892081182 cites W2172178713 @default.
- W2892081182 cites W2215599424 @default.
- W2892081182 cites W2256756668 @default.
- W2892081182 cites W2267372659 @default.
- W2892081182 cites W2307033856 @default.
- W2892081182 cites W2345798949 @default.
- W2892081182 cites W2442899697 @default.
- W2892081182 cites W2520535192 @default.
- W2892081182 cites W2604114683 @default.
- W2892081182 cites W2791385084 @default.
- W2892081182 cites W308266237 @default.
- W2892081182 cites W4248552215 @default.
- W2892081182 doi "https://doi.org/10.1016/j.vaccine.2018.09.014" @default.
- W2892081182 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30243502" @default.
- W2892081182 hasPublicationYear "2018" @default.
- W2892081182 type Work @default.
- W2892081182 sameAs 2892081182 @default.
- W2892081182 citedByCount "20" @default.
- W2892081182 countsByYear W28920811822019 @default.
- W2892081182 countsByYear W28920811822020 @default.
- W2892081182 countsByYear W28920811822021 @default.
- W2892081182 countsByYear W28920811822022 @default.
- W2892081182 countsByYear W28920811822023 @default.
- W2892081182 crossrefType "journal-article" @default.
- W2892081182 hasAuthorship W2892081182A5000432967 @default.
- W2892081182 hasAuthorship W2892081182A5000605053 @default.
- W2892081182 hasAuthorship W2892081182A5013752180 @default.
- W2892081182 hasAuthorship W2892081182A5016759484 @default.
- W2892081182 hasAuthorship W2892081182A5023874610 @default.
- W2892081182 hasAuthorship W2892081182A5036548928 @default.
- W2892081182 hasAuthorship W2892081182A5037989560 @default.
- W2892081182 hasAuthorship W2892081182A5059797825 @default.
- W2892081182 hasAuthorship W2892081182A5065968878 @default.
- W2892081182 hasAuthorship W2892081182A5067307509 @default.
- W2892081182 hasBestOaLocation W28920811821 @default.
- W2892081182 hasConcept C159047783 @default.
- W2892081182 hasConcept C159654299 @default.
- W2892081182 hasConcept C203014093 @default.
- W2892081182 hasConcept C22070199 @default.
- W2892081182 hasConcept C2522874641 @default.
- W2892081182 hasConcept C2775862345 @default.
- W2892081182 hasConcept C2779341262 @default.
- W2892081182 hasConcept C61716771 @default.
- W2892081182 hasConcept C71924100 @default.
- W2892081182 hasConcept C86803240 @default.
- W2892081182 hasConcept C8891405 @default.
- W2892081182 hasConcept C89138240 @default.
- W2892081182 hasConcept C89423630 @default.
- W2892081182 hasConceptScore W2892081182C159047783 @default.
- W2892081182 hasConceptScore W2892081182C159654299 @default.
- W2892081182 hasConceptScore W2892081182C203014093 @default.
- W2892081182 hasConceptScore W2892081182C22070199 @default.
- W2892081182 hasConceptScore W2892081182C2522874641 @default.
- W2892081182 hasConceptScore W2892081182C2775862345 @default.
- W2892081182 hasConceptScore W2892081182C2779341262 @default.
- W2892081182 hasConceptScore W2892081182C61716771 @default.
- W2892081182 hasConceptScore W2892081182C71924100 @default.
- W2892081182 hasConceptScore W2892081182C86803240 @default.
- W2892081182 hasConceptScore W2892081182C8891405 @default.
- W2892081182 hasConceptScore W2892081182C89138240 @default.
- W2892081182 hasConceptScore W2892081182C89423630 @default.
- W2892081182 hasFunder F4320337504 @default.
- W2892081182 hasIssue "45" @default.