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- W2892085140 endingPage "2385" @default.
- W2892085140 startingPage "2373" @default.
- W2892085140 abstract "Abstract Erythropoiesis is a multi‐step process that involves the differentiation of hematopoietic stem cells into mature red blood cells (RBCs). This process is regulated by several signaling pathways, transcription factors and microRNAs (miRNAs). Many studies have shown that dysregulation of this process can lead to hematologic disorders. PI3K/AKT is one of the most important pathways that control many cellular processes including, cell division, autophagy, survival, and differentiation. In this review, we focus on the role of PI3K/AKT pathway in erythropoiesis and discuss the function of some of the most important genes, transcription factors, and miRNAs that regulate different stages of erythropoiesis which play roles in differentiation and maturation of RBCs, prevention of apoptosis, and autophagy induction. Understanding the role of the PI3K pathway in erythropoiesis may provide new insights into diagnosing erythrocyte disorders." @default.
- W2892085140 created "2018-09-27" @default.
- W2892085140 creator A5024120960 @default.
- W2892085140 creator A5027057043 @default.
- W2892085140 creator A5063385676 @default.
- W2892085140 creator A5075057865 @default.
- W2892085140 date "2018-09-07" @default.
- W2892085140 modified "2023-10-16" @default.
- W2892085140 title "PI3k/AKT signaling pathway: Erythropoiesis and beyond" @default.
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