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- W2892087513 abstract "The goal of the present study was to determine gene expression profiles that change in response to a high fat diet (HFD) in white and brown adipose. Male C57Bl/6 mice were fed a control (10% kcal) or a HFD (60% kcal) for 12 wks. Genome-wide expression profiles were examined in five adipose depots (epididymal (EPAT), perirenal (PRAT), subcutaneous (SCAT), perivascular (PVAT), subscapular (SSAT)) using the Affymetrix platform (GeneChip® Mouse 1.0 ST Array). Expression differences were analyzed using ±2-fold change (P<0.05) and gene network analysis was performed using Ingenuity Pathway Analysis. In PVAT and SCAT, 21 and 45 genes respectively were found to be differentially expressed. In brown SSAT, 47 genes were differentially expressed; 25 of which were downregulated by 11- fold or greater and were classified as muscle-specific. 130 and 41 genes were found to be differentially expressed in visceral EPAT and PRAT, respectively. In both EPAT and PRAT a number of genes related to inflammation were upregulated. Overall, GPR50 (an orphan receptor implicated in metabolism) had the greatest change in expression (29- & 60-fold increase) in response to a HFD in PRAT and EPAT, respectively. In total, these data demonstrate that in response to a HFD there are gene expression profiles that are shared between adipose depots as well as genes/pathways that differentiate adipose types. Supported by NIH HL-089884 & HL-107632." @default.
- W2892087513 created "2018-09-27" @default.
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- W2892087513 date "2013-04-01" @default.
- W2892087513 modified "2023-10-16" @default.
- W2892087513 title "DIFFERENTIAL GENE EXPRESSION PROFILES PRODUCED BY A HIGH FAT DIET IN WHITE AND BROWN ADIPOSE" @default.
- W2892087513 doi "https://doi.org/10.1096/fasebj.27.1_supplement.738.3" @default.
- W2892087513 hasPublicationYear "2013" @default.
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