FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892091513> ?p ?o ?g. }

• W2892091513 abstract "Synaptic dysfunction in CNS disorders is the outcome of perturbations in physiological synapse structure and function, and can be either the cause or the consequence in specific pathologies. Accumulating data in the field of neuropsychiatric disorders, including autism spectrum disorders, schizophrenia and bipolar disorder, point to a neurodevelopmental origin of these pathologies. Due to a relatively early onset of behavioural and cognitive symptoms, it is generally acknowledged that mental illness initiates at the synapse level. On the other hand, synaptic dysfunction has been considered as an endpoint incident in neurodegenerative diseases, such as Alzheimer's, Parkinson's and Huntington's, mainly due to the considerably later onset of clinical symptoms and progressive appearance of cognitive deficits. This dichotomy has recently been challenged, particularly since the discovery of cell reprogramming technologies and the generation of induced pluripotent stem cells from patient somatic cells. The creation of 'disease-in-a-dish' models for multiple CNS pathologies has revealed unexpected commonalities in the molecular and cellular mechanisms operating in both developmental and degenerative conditions, most of which meet at the synapse level. In this review we discuss synaptic dysfunction in prototype neurodevelopmental and neurodegenerative diseases, emphasizing overlapping features of synaptopathy that have been suggested by studies using induced pluripotent stem-cell-based systems. These valuable disease models have highlighted a potential neurodevelopmental component in classical neurodegenerative diseases that is worth pursuing and investigating further. Moving from demonstration of correlation to understanding mechanistic causality forms the basis for developing novel therapeutics." @default.
• W2892091513 created "2018-09-27" @default.
• W2892091513 creator A5002169750 @default.
• W2892091513 creator A5011775320 @default.
• W2892091513 creator A5049854491 @default.
• W2892091513 creator A5049912899 @default.
• W2892091513 date "2018-09-01" @default.
• W2892091513 modified "2023-10-17" @default.
• W2892091513 title "Synaptic dysfunction in neurodegenerative and neurodevelopmental diseases: an overview of induced pluripotent stem-cell-based disease models" @default.
• W2892091513 cites W1527671059 @default.
• W2892091513 cites W1539348188 @default.
• W2892091513 cites W1553983967 @default.
• W2892091513 cites W1570630920 @default.
• W2892091513 cites W1588910430 @default.
• W2892091513 cites W1602704039 @default.
• W2892091513 cites W1618384257 @default.
• W2892091513 cites W1671213273 @default.
• W2892091513 cites W1768523798 @default.
• W2892091513 cites W1835928992 @default.
• W2892091513 cites W1923089788 @default.
• W2892091513 cites W1925951634 @default.
• W2892091513 cites W1934491565 @default.
• W2892091513 cites W1965798965 @default.
• W2892091513 cites W1968461255 @default.
• W2892091513 cites W1972975669 @default.
• W2892091513 cites W1974373184 @default.
• W2892091513 cites W1977044612 @default.
• W2892091513 cites W1979285653 @default.
• W2892091513 cites W1979591162 @default.
• W2892091513 cites W1980402099 @default.
• W2892091513 cites W1980911768 @default.
• W2892091513 cites W1984678540 @default.
• W2892091513 cites W1988369116 @default.
• W2892091513 cites W1990326740 @default.
• W2892091513 cites W1991721037 @default.
• W2892091513 cites W1994831877 @default.
• W2892091513 cites W1996154142 @default.
• W2892091513 cites W1997031801 @default.
• W2892091513 cites W1999288515 @default.
• W2892091513 cites W2003126320 @default.
• W2892091513 cites W2003835684 @default.
• W2892091513 cites W2008831180 @default.
• W2892091513 cites W2009573330 @default.
• W2892091513 cites W2011556222 @default.
• W2892091513 cites W2011835273 @default.
• W2892091513 cites W2014444260 @default.
• W2892091513 cites W2017040646 @default.
• W2892091513 cites W2018133355 @default.
• W2892091513 cites W2018286352 @default.
• W2892091513 cites W2019480042 @default.
• W2892091513 cites W2020117714 @default.
• W2892091513 cites W2020518096 @default.
• W2892091513 cites W2020914828 @default.
• W2892091513 cites W2021800885 @default.
• W2892091513 cites W2023962370 @default.
• W2892091513 cites W2025012646 @default.
• W2892091513 cites W2026088138 @default.
• W2892091513 cites W2027438121 @default.
• W2892091513 cites W2028033268 @default.
• W2892091513 cites W2033799616 @default.
• W2892091513 cites W2040027262 @default.
• W2892091513 cites W2040900433 @default.
• W2892091513 cites W2042334009 @default.
• W2892091513 cites W2042920344 @default.
• W2892091513 cites W2045314069 @default.
• W2892091513 cites W2046895212 @default.
• W2892091513 cites W2047185996 @default.
• W2892091513 cites W2048834720 @default.
• W2892091513 cites W2050465941 @default.
• W2892091513 cites W2051087311 @default.
• W2892091513 cites W2054302986 @default.
• W2892091513 cites W2055854310 @default.
• W2892091513 cites W2055927110 @default.
• W2892091513 cites W2056922981 @default.
• W2892091513 cites W2060801754 @default.
• W2892091513 cites W2062879575 @default.
• W2892091513 cites W2063032803 @default.
• W2892091513 cites W2063127941 @default.
• W2892091513 cites W2063156659 @default.
• W2892091513 cites W2064226680 @default.
• W2892091513 cites W2066058435 @default.
• W2892091513 cites W2068515212 @default.
• W2892091513 cites W2069607629 @default.
• W2892091513 cites W2071482305 @default.
• W2892091513 cites W2075109360 @default.
• W2892091513 cites W2076127858 @default.
• W2892091513 cites W2079378641 @default.
• W2892091513 cites W2080536654 @default.
• W2892091513 cites W2081914422 @default.
• W2892091513 cites W2084620265 @default.
• W2892091513 cites W2087786585 @default.
• W2892091513 cites W2088714934 @default.
• W2892091513 cites W2088778610 @default.
• W2892091513 cites W2089993812 @default.
• W2892091513 cites W2090495936 @default.
• W2892091513 cites W2091265794 @default.
• W2892091513 cites W2093322139 @default.
• W2892091513 cites W2093574402 @default.
• W2892091513 cites W2095860692 @default.
• W2892091513 cites W2101357408 @default.

• next