FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892092899> ?p ?o ?g. }

• W2892092899 abstract "A complex mix of inflammatory and microbial associations underscores the chronic inflammatory condition chronic rhinosinusitis (CRS), and the etiology remains poorly understood. Recent work has begun to delineate between variants (endotypes) of CRS on the basis of inflammatory biomarkers. This study aimed to assess inflammatory patterns in CRS phenotypes, identify putative endotypes of CRS, and to assess inflammatory associations with the sinonasal microbiota. Ten cytokines and six inflammatory cell types were assessed in mucosal biopsies from 93 CRS subjects and 17 controls via cytometric bead array and immunohistochemical techniques. Putative endotypes were identified via cluster analysis of subjects on the basis of inflammatory markers and comorbidities including polyposis, asthma, and aspirin sensitivity. Finally, previously published bacterial data for this cohort were reanalyzed to evaluate associations with inflammatory markers and CRS subtypes. Inflammatory patterns were highly variable within standard CRS phenotypes. Cluster analysis identified eight subject clusters, with strong delineation on the basis of polyposis and asthma, but also subtle distinctions in inflammatory markers. An association was also identified between depletion of several health-associated bacterial taxa, reduced bacterial diversity and increased overall bacterial load, with markers of inflammation and clinical severity. This study contributes to ongoing efforts to define distinct endotypes of CRS on the basis of underlying inflammatory processes, and also offers compelling evidence of a link between bacterial community dysbiosis and inflammation in CRS. Further resolving the heterogeneity of CRS is vital to inform clinical management and personalized treatment approaches." @default.
• W2892092899 created "2018-09-27" @default.
• W2892092899 creator A5005419095 @default.
• W2892092899 creator A5014704218 @default.
• W2892092899 creator A5031134193 @default.
• W2892092899 creator A5040475815 @default.
• W2892092899 creator A5050560917 @default.
• W2892092899 creator A5051245642 @default.
• W2892092899 creator A5059395368 @default.
• W2892092899 creator A5076857866 @default.
• W2892092899 creator A5087530975 @default.
• W2892092899 date "2018-09-19" @default.
• W2892092899 modified "2023-10-16" @default.
• W2892092899 title "Inflammatory Endotypes and Microbial Associations in Chronic Rhinosinusitis" @default.
• W2892092899 cites W1437698845 @default.
• W2892092899 cites W1885435857 @default.
• W2892092899 cites W1933395431 @default.
• W2892092899 cites W1968876836 @default.
• W2892092899 cites W1985121334 @default.
• W2892092899 cites W2008945707 @default.
• W2892092899 cites W2014538668 @default.
• W2892092899 cites W2026583845 @default.
• W2892092899 cites W2031802002 @default.
• W2892092899 cites W2036867429 @default.
• W2892092899 cites W2049865778 @default.
• W2892092899 cites W2061554433 @default.
• W2892092899 cites W2067324660 @default.
• W2892092899 cites W2070011856 @default.
• W2892092899 cites W2074963908 @default.
• W2892092899 cites W2083993387 @default.
• W2892092899 cites W2088149329 @default.
• W2892092899 cites W2095499340 @default.
• W2892092899 cites W2122844960 @default.
• W2892092899 cites W2124949166 @default.
• W2892092899 cites W2139695940 @default.
• W2892092899 cites W2208093466 @default.
• W2892092899 cites W2229592293 @default.
• W2892092899 cites W2274336448 @default.
• W2892092899 cites W2279981039 @default.
• W2892092899 cites W2289316671 @default.
• W2892092899 cites W2295678160 @default.
• W2892092899 cites W2342988903 @default.
• W2892092899 cites W2345612993 @default.
• W2892092899 cites W2424565233 @default.
• W2892092899 cites W2427062493 @default.
• W2892092899 cites W2462860861 @default.
• W2892092899 cites W2494710035 @default.
• W2892092899 cites W2551760472 @default.
• W2892092899 cites W2554506152 @default.
• W2892092899 cites W2554888359 @default.
• W2892092899 cites W2557580049 @default.
• W2892092899 cites W2558524460 @default.
• W2892092899 cites W2566872722 @default.
• W2892092899 cites W2612824952 @default.
• W2892092899 cites W2775224509 @default.
• W2892092899 cites W3183099619 @default.
• W2892092899 cites W4251650664 @default.
• W2892092899 cites W841511375 @default.
• W2892092899 doi "https://doi.org/10.3389/fimmu.2018.02065" @default.
• W2892092899 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6157407" @default.
• W2892092899 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30283438" @default.
• W2892092899 hasPublicationYear "2018" @default.
• W2892092899 type Work @default.
• W2892092899 sameAs 2892092899 @default.
• W2892092899 citedByCount "41" @default.
• W2892092899 countsByYear W28920928992019 @default.
• W2892092899 countsByYear W28920928992020 @default.
• W2892092899 countsByYear W28920928992021 @default.
• W2892092899 countsByYear W28920928992022 @default.
• W2892092899 countsByYear W28920928992023 @default.
• W2892092899 crossrefType "journal-article" @default.
• W2892092899 hasAuthorship W2892092899A5005419095 @default.
• W2892092899 hasAuthorship W2892092899A5014704218 @default.
• W2892092899 hasAuthorship W2892092899A5031134193 @default.
• W2892092899 hasAuthorship W2892092899A5040475815 @default.
• W2892092899 hasAuthorship W2892092899A5050560917 @default.
• W2892092899 hasAuthorship W2892092899A5051245642 @default.
• W2892092899 hasAuthorship W2892092899A5059395368 @default.
• W2892092899 hasAuthorship W2892092899A5076857866 @default.
• W2892092899 hasAuthorship W2892092899A5087530975 @default.
• W2892092899 hasBestOaLocation W28920928991 @default.
• W2892092899 hasConcept C126322002 @default.
• W2892092899 hasConcept C137627325 @default.
• W2892092899 hasConcept C143121216 @default.
• W2892092899 hasConcept C203014093 @default.
• W2892092899 hasConcept C2776042228 @default.
• W2892092899 hasConcept C2776914184 @default.
• W2892092899 hasConcept C2777165150 @default.
• W2892092899 hasConcept C2779134260 @default.
• W2892092899 hasConcept C2781293274 @default.
• W2892092899 hasConcept C2781390199 @default.
• W2892092899 hasConcept C3019717275 @default.
• W2892092899 hasConcept C539455810 @default.
• W2892092899 hasConcept C60644358 @default.
• W2892092899 hasConcept C71924100 @default.
• W2892092899 hasConcept C86803240 @default.
• W2892092899 hasConceptScore W2892092899C126322002 @default.
• W2892092899 hasConceptScore W2892092899C137627325 @default.
• W2892092899 hasConceptScore W2892092899C143121216 @default.
• W2892092899 hasConceptScore W2892092899C203014093 @default.

• next