Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892093789> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2892093789 abstract "Spasticity is a common presentation in a wide variety of neurological disorders like cerebral palsy (CP), multiple sclerosis, and spinal cord injury. Management of spasticity involves multiple modalities such as physical and occupational therapy, oral medicines, Botulinum toxin injection, and orthopaedic and neurosurgical intervention. Intrathecal Baclofen (ITB) therapy is one neurosurgical intervention to control spasticity in CP patients. The ITB pump is implanted subcutaneously or sub-facially in the abdomen which delivers the baclofen directly to the intrathecal space via a catheter. As a result of by-passing the blood-brain-barrier, intrathecal administration of a hundredth part of the oral baclofen dose is sufficient to relieve spasticity and therefore preventing the peripheral side-effects seen with oral administration. Although the ITB delivery systems demonstrate significant effectiveness in improving spasticity, the ITB delivery system is associated with a high complication rate which could interfere with the desired effect of ITB therapy. Therefore, in a retrospective observational study we aimed to analyse the ITB complications in a large (n=222) consecutive series of patients. The complication rate in relation to the long period of follow-up (939 pump years),was found to be similar or less than those reported in literature. Dystonia, young age and presence of gastrostomy tube were significantly associated with infective complications. Catheter complications were influenced by presence of dystonia and the surgical technique, whether it was a subfascial or subcutaneous implantation.The pump is refilled by baclofen solution. The frequency of refilling is dependent on the daily dosing regime and the concentration of the aqueous solution of baclofen in the pump. Baclofen solutions are available as commercial and compounded products. An experimental controlled study was conducted to evaluate the safety of using higher concentrations of compounded baclofen in comparison to commercial baclofen. Baclofen concentration of the compounded solution was found to be less accurate than the commercial product although it was within an acceptable range from the expected value. The number of invisible particulates was significantly higher in the compounded solution than in commercial baclofen. However, no clinical complications were reported in the compounded or in the commercial baclofen groups.As patients receiving ITB therapy may have clinical benefits of reduction of the severity of spasticity, they could also have improvements in their functional status and quality of life. A survey study to evaluate changes in functional status and heath related quality of life, showed improvement in both aspects, moreover, the improvement in the health related quality of life was more significant than the change in functional status." @default.
- W2892093789 created "2018-09-27" @default.
- W2892093789 creator A5039262967 @default.
- W2892093789 date "2018-07-12" @default.
- W2892093789 modified "2023-09-23" @default.
- W2892093789 title "Intrathecal baclofen therapy for treatment of spasticity and dystonia in childhood" @default.
- W2892093789 hasPublicationYear "2018" @default.
- W2892093789 type Work @default.
- W2892093789 sameAs 2892093789 @default.
- W2892093789 citedByCount "0" @default.
- W2892093789 crossrefType "dissertation" @default.
- W2892093789 hasAuthorship W2892093789A5039262967 @default.
- W2892093789 hasConcept C118552586 @default.
- W2892093789 hasConcept C126322002 @default.
- W2892093789 hasConcept C141071460 @default.
- W2892093789 hasConcept C170493617 @default.
- W2892093789 hasConcept C2777478456 @default.
- W2892093789 hasConcept C2778559928 @default.
- W2892093789 hasConcept C2778938600 @default.
- W2892093789 hasConcept C2779012798 @default.
- W2892093789 hasConcept C2781201050 @default.
- W2892093789 hasConcept C42219234 @default.
- W2892093789 hasConcept C71924100 @default.
- W2892093789 hasConcept C81182388 @default.
- W2892093789 hasConceptScore W2892093789C118552586 @default.
- W2892093789 hasConceptScore W2892093789C126322002 @default.
- W2892093789 hasConceptScore W2892093789C141071460 @default.
- W2892093789 hasConceptScore W2892093789C170493617 @default.
- W2892093789 hasConceptScore W2892093789C2777478456 @default.
- W2892093789 hasConceptScore W2892093789C2778559928 @default.
- W2892093789 hasConceptScore W2892093789C2778938600 @default.
- W2892093789 hasConceptScore W2892093789C2779012798 @default.
- W2892093789 hasConceptScore W2892093789C2781201050 @default.
- W2892093789 hasConceptScore W2892093789C42219234 @default.
- W2892093789 hasConceptScore W2892093789C71924100 @default.
- W2892093789 hasConceptScore W2892093789C81182388 @default.
- W2892093789 hasLocation W28920937891 @default.
- W2892093789 hasOpenAccess W2892093789 @default.
- W2892093789 hasPrimaryLocation W28920937891 @default.
- W2892093789 hasRelatedWork W119687405 @default.
- W2892093789 hasRelatedWork W1509804422 @default.
- W2892093789 hasRelatedWork W1519306115 @default.
- W2892093789 hasRelatedWork W1595653760 @default.
- W2892093789 hasRelatedWork W2054434853 @default.
- W2892093789 hasRelatedWork W2072423353 @default.
- W2892093789 hasRelatedWork W2089639743 @default.
- W2892093789 hasRelatedWork W2271263705 @default.
- W2892093789 hasRelatedWork W2276456611 @default.
- W2892093789 hasRelatedWork W2281799097 @default.
- W2892093789 hasRelatedWork W2315215545 @default.
- W2892093789 hasRelatedWork W2397867360 @default.
- W2892093789 hasRelatedWork W2406264500 @default.
- W2892093789 hasRelatedWork W2441212506 @default.
- W2892093789 hasRelatedWork W2552528018 @default.
- W2892093789 hasRelatedWork W2559660977 @default.
- W2892093789 hasRelatedWork W2599266032 @default.
- W2892093789 hasRelatedWork W2792447188 @default.
- W2892093789 hasRelatedWork W3100522703 @default.
- W2892093789 hasRelatedWork W3137837149 @default.
- W2892093789 isParatext "false" @default.
- W2892093789 isRetracted "false" @default.
- W2892093789 magId "2892093789" @default.
- W2892093789 workType "dissertation" @default.