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- W2892093839 endingPage "32" @default.
- W2892093839 startingPage "25" @default.
- W2892093839 abstract "The Hippo-YAP (Yes-associated protein) pathway is a key regulator of tissue growth, organ size and stem cell function. More recently, a fundamental role for this pathway has emerged in stem cell function and tumorigenesis. Activation of the transcriptional co-activator YAP promotes cell-contact independent proliferation, epithelial to mesenchymal transition (EMT), cancer stem cell features and drug resistance. In this review, we describe the main components of the pathway, the microenvironment and the cell-intrinsic cues governing its activation, the downstream players of the pathway and the biological implications of their activation in the context of cancer. We will focus on the existing knowledge of this pathway in head and neck squamous carcinoma (HNSCC), its clinical value in this type of cancer as a marker of poor prognosis and resistance to therapy, as well as the most encouraging therapeutic strategies targeting the pathway." @default.
- W2892093839 created "2018-09-27" @default.
- W2892093839 creator A5002672600 @default.
- W2892093839 creator A5028054823 @default.
- W2892093839 creator A5070674443 @default.
- W2892093839 date "2018-11-01" @default.
- W2892093839 modified "2023-10-08" @default.
- W2892093839 title "The transcriptional co-activator YAP: A new player in head and neck cancer" @default.
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