FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892095134> ?p ?o ?g. }

• W2892095134 endingPage "2631" @default.
• W2892095134 startingPage "2617" @default.
• W2892095134 abstract "Abstract We and others previously showed that in mouse embryos lacking the transcription factor Sox10, olfactory ensheathing cell (OEC) differentiation is disrupted, resulting in defective olfactory axon targeting and fewer gonadotropin‐releasing hormone (GnRH) neurons entering the embryonic forebrain. The underlying mechanisms are unclear. Here, we report that OECs in the olfactory nerve layer express Frzb —encoding a secreted Wnt inhibitor with roles in axon targeting and basement membrane breakdown—from embryonic day (E)12.5, when GnRH neurons first enter the forebrain, until E16.5, the latest stage examined. The highest levels of Frzb expression are seen in OECs in the inner olfactory nerve layer, abutting the embryonic olfactory bulb. We find that Sox10 is required for Frzb expression in OECs, suggesting that loss of Frzb could explain the olfactory axon targeting and/or GnRH neuron migration defects seen in Sox10 ‐null mice. At E16.5, Frzb ‐null embryos show significant reductions in both the volume of the olfactory nerve layer expressing the maturation marker Omp and the number of Omp‐positive olfactory receptor neurons in the olfactory epithelium. As Omp upregulation correlates with synapse formation, this suggests that Frzb deletion indeed disrupts olfactory axon targeting. In contrast, GnRH neuron entry into the forebrain is not significantly affected. Hence, loss of Frzb may contribute to the olfactory axon targeting phenotype, but not the GnRH neuron phenotype, of Sox10 ‐null mice. Overall, our results suggest that Frzb secreted from OECs in the olfactory nerve layer is important for olfactory axon targeting." @default.
• W2892095134 created "2018-09-27" @default.
• W2892095134 creator A5009819161 @default.
• W2892095134 creator A5031502924 @default.
• W2892095134 creator A5033297722 @default.
• W2892095134 creator A5036108107 @default.
• W2892095134 creator A5057225004 @default.
• W2892095134 creator A5061665380 @default.
• W2892095134 creator A5069149049 @default.
• W2892095134 creator A5071545688 @default.
• W2892095134 creator A5089045595 @default.
• W2892095134 date "2018-09-26" @default.
• W2892095134 modified "2023-10-12" @default.
• W2892095134 title "Olfactory ensheathing cells abutting the embryonic olfactory bulb express <i>Frzb</i> , whose deletion disrupts olfactory axon targeting" @default.
• W2892095134 cites W1484289528 @default.
• W2892095134 cites W1497716046 @default.
• W2892095134 cites W1504482130 @default.
• W2892095134 cites W1544171093 @default.
• W2892095134 cites W1558002500 @default.
• W2892095134 cites W1559947327 @default.
• W2892095134 cites W1740677000 @default.
• W2892095134 cites W1843688890 @default.
• W2892095134 cites W1939775897 @default.
• W2892095134 cites W1965857163 @default.
• W2892095134 cites W1966100962 @default.
• W2892095134 cites W1967588227 @default.
• W2892095134 cites W1968298199 @default.
• W2892095134 cites W1969385197 @default.
• W2892095134 cites W1974869504 @default.
• W2892095134 cites W1975957256 @default.
• W2892095134 cites W1981780292 @default.
• W2892095134 cites W1993957466 @default.
• W2892095134 cites W1994607750 @default.
• W2892095134 cites W1997438217 @default.
• W2892095134 cites W1997999543 @default.
• W2892095134 cites W1998382665 @default.
• W2892095134 cites W1999902843 @default.
• W2892095134 cites W2000283379 @default.
• W2892095134 cites W2005791282 @default.
• W2892095134 cites W2007800426 @default.
• W2892095134 cites W2008991834 @default.
• W2892095134 cites W2012441839 @default.
• W2892095134 cites W2018520808 @default.
• W2892095134 cites W2019121484 @default.
• W2892095134 cites W2029618197 @default.
• W2892095134 cites W2031373711 @default.
• W2892095134 cites W2032019813 @default.
• W2892095134 cites W2032320771 @default.
• W2892095134 cites W2033937600 @default.
• W2892095134 cites W2034997186 @default.
• W2892095134 cites W2041566392 @default.
• W2892095134 cites W2043147436 @default.
• W2892095134 cites W2044413297 @default.
• W2892095134 cites W2047334208 @default.
• W2892095134 cites W2048711372 @default.
• W2892095134 cites W2051043176 @default.
• W2892095134 cites W2052876896 @default.
• W2892095134 cites W2057193534 @default.
• W2892095134 cites W2060931924 @default.
• W2892095134 cites W2061974630 @default.
• W2892095134 cites W2063366035 @default.
• W2892095134 cites W2066575611 @default.
• W2892095134 cites W2066599840 @default.
• W2892095134 cites W2067422295 @default.
• W2892095134 cites W2067449016 @default.
• W2892095134 cites W2068775337 @default.
• W2892095134 cites W2069132169 @default.
• W2892095134 cites W2070266301 @default.
• W2892095134 cites W2077247278 @default.
• W2892095134 cites W2088966106 @default.
• W2892095134 cites W2089269195 @default.
• W2892095134 cites W2089598622 @default.
• W2892095134 cites W2094065856 @default.
• W2892095134 cites W2099540110 @default.
• W2892095134 cites W2099882112 @default.
• W2892095134 cites W2100075263 @default.
• W2892095134 cites W2112978647 @default.
• W2892095134 cites W2115533079 @default.
• W2892095134 cites W2135914580 @default.
• W2892095134 cites W2137608891 @default.
• W2892095134 cites W2137909022 @default.
• W2892095134 cites W2159559944 @default.
• W2892095134 cites W2162098634 @default.
• W2892095134 cites W2162529637 @default.
• W2892095134 cites W2296364070 @default.
• W2892095134 cites W2413947359 @default.
• W2892095134 cites W2586146601 @default.
• W2892095134 cites W2762642874 @default.
• W2892095134 doi "https://doi.org/10.1002/glia.23515" @default.
• W2892095134 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6517278" @default.
• W2892095134 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30256452" @default.
• W2892095134 hasPublicationYear "2018" @default.
• W2892095134 type Work @default.
• W2892095134 sameAs 2892095134 @default.
• W2892095134 citedByCount "12" @default.
• W2892095134 countsByYear W28920951342019 @default.
• W2892095134 countsByYear W28920951342020 @default.
• W2892095134 countsByYear W28920951342021 @default.

• next