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- W2892098711 endingPage "133" @default.
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- W2892098711 abstract "Current evidence strongly suggests that aberrant activation of the NF-κB signalling pathway is associated with carcinogenesis. A number of key cellular processes are governed by the effectors of this pathway, including immune responses and apoptosis, both crucial in the development of cancer. Therefore, it is not surprising that dysregulated and chronic NF-κB signalling can have a profound impact on cellular homeostasis. Here we discuss NFKB1 (p105/p50), one of the five subunits of NF-κB, widely implicated in carcinogenesis, in some cases driving cancer progression and in others acting as a tumour-suppressor. The complexity of the role of this subunit lies in the multiple dimeric combination possibilities as well as the different interacting co-factors, which dictate whether gene transcription is activated or repressed, in a cell and organ-specific manner. This review highlights the multiple roles of NFKB1 in the development and progression of different cancers, and the considerations to make when attempting to manipulate NF-κB as a potential cancer therapy." @default.
- W2892098711 created "2018-09-27" @default.
- W2892098711 creator A5022190021 @default.
- W2892098711 creator A5078207582 @default.
- W2892098711 date "2018-09-07" @default.
- W2892098711 modified "2023-09-30" @default.
- W2892098711 title "NFKB1 and Cancer: Friend or Foe?" @default.
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- W2892098711 doi "https://doi.org/10.3390/cells7090133" @default.
- W2892098711 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6162711" @default.
- W2892098711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30205516" @default.
- W2892098711 hasPublicationYear "2018" @default.
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