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• W2892100522 startingPage "27" @default.
• W2892100522 abstract "High titer, productivity and yield are the main pre-requisites of an efficient lactic acid production process. However, the hyperosmotic stress inhibits cell metabolism in the later phase of fermentation. In this study, an osmotic-tolerant mutant named Lactobacillus paracasei NCBIO01-M2 was obtained through a high-throughput screening technology, which exhibited a higher tolerance to osmotic stress due to its more flexible regulation of the unsaturated fatty acid proportion along with the intracellular compatible solute pools. The mutant successfully consumed all 248 g/L initial glucose and produced 223.7 g/L lactic acid with a productivity of 5.53 g/L/h in a single batch fermentation by the neutralizing agent strategy. Moreover, similar fermentation performances were also achieved in the open fermentation mode without sterilization by the mutant, which suggested that the mutant would be a potential for cost-effective commercial lactic acid production." @default.
• W2892100522 created "2018-09-27" @default.
• W2892100522 creator A5015550137 @default.
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• W2892100522 date "2018-11-01" @default.
• W2892100522 modified "2023-10-18" @default.
• W2892100522 title "Exploring cellular fatty acid composition and intracellular metabolites of osmotic-tolerant mutant Lactobacillus paracasei NCBIO-M2 for highly efficient lactic acid production with high initial glucose concentration" @default.
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• W2892100522 doi "https://doi.org/10.1016/j.jbiotec.2018.09.005" @default.
• W2892100522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30218678" @default.
• W2892100522 hasPublicationYear "2018" @default.
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