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• W2892114219 endingPage "921" @default.
• W2892114219 startingPage "915" @default.
• W2892114219 abstract "Background and Objectives The aim of this study was to perform a retrospective analysis of survival rates and determine prognostic indicators for patients who underwent definitive surgical resection of stage IV melanoma. Methods Patients included were those who underwent complete resection of metastatic melanoma. Data was analyzed using IBM SPSS 2.0. Survival estimates were derived from Kaplan‐Meier, log‐rank, and Breslow tests. Results The study population (n = 95) consisted of 60 males and 35 females. Median overall survival (OS) from the first metastasectomy was 49 months (95% confidence interval, 31‐67 months). OS at 1, 2, and 5 years was 92%, 87%, and 50% respectively. Predictors of survival included clear surgical margins compared to patients with positive margins (median OS 53 vs 20 months, P = .026). A preoperative neutrophil to lymphocyte ratio less than 5 experienced a median OS of 65 months compared to 15 months ( P = .006; multivariable analysis for OS: hazard ratio 3.590, P = .009). Conclusion This study's results are consistent with previous findings demonstrating favourable long‐term outcomes following selective resection of metastatic melanoma. In addition to achieving clear surgical margins, a low preoperative neutrophil to lymphocyte ratio was associated with improved outcomes. These factors may help identify surgical candidates." @default.
• W2892114219 created "2018-09-27" @default.
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• W2892114219 date "2018-09-09" @default.
• W2892114219 modified "2023-09-27" @default.
• W2892114219 title "Neutrophil to lymphocyte ratio is an independent predictor of outcome for patients undergoing definitive resection for stage IV melanoma" @default.
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• W2892114219 doi "https://doi.org/10.1002/jso.25138" @default.
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