Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892146033> ?p ?o ?g. }
- W2892146033 abstract "Abstract The complex neuropathology of traumatic brain injury (TBI) is difficult to dissect, given the convoluted cytoarchitecture of affected brain regions such as the hippocampus. Hippocampal dysfunction during TBI results in cognitive decline that may escalate to other neurological disorders, the molecular basis of which is hidden in the genomic programs of individual cells. Using the unbiased single cell sequencing method Drop-seq, we report that concussive TBI affects previously undefined cell populations, in addition to classical hippocampal cell types. TBI also impacts cell type-specific genes and pathways and alters gene co-expression across cell types, suggesting hidden pathogenic mechanisms and therapeutic target pathways. Modulating the thyroid hormone pathway as informed by the T4 transporter transthyretin Ttr mitigates TBI-associated genomic and behavioral abnormalities. Thus, single cell genomics provides unique information about how TBI impacts diverse hippocampal cell types, adding new insights into the pathogenic pathways amenable to therapeutics in TBI and related disorders." @default.
- W2892146033 created "2018-09-27" @default.
- W2892146033 creator A5014686940 @default.
- W2892146033 creator A5020876132 @default.
- W2892146033 creator A5038362399 @default.
- W2892146033 creator A5050517394 @default.
- W2892146033 creator A5057009272 @default.
- W2892146033 creator A5060552570 @default.
- W2892146033 creator A5070853840 @default.
- W2892146033 creator A5088751229 @default.
- W2892146033 date "2018-09-25" @default.
- W2892146033 modified "2023-10-16" @default.
- W2892146033 title "Single cell molecular alterations reveal target cells and pathways of concussive brain injury" @default.
- W2892146033 cites W1490161904 @default.
- W2892146033 cites W1544883203 @default.
- W2892146033 cites W1545338101 @default.
- W2892146033 cites W1582986153 @default.
- W2892146033 cites W1918140288 @default.
- W2892146033 cites W1943916690 @default.
- W2892146033 cites W1961000729 @default.
- W2892146033 cites W1965577101 @default.
- W2892146033 cites W1979283544 @default.
- W2892146033 cites W1988628469 @default.
- W2892146033 cites W1989277387 @default.
- W2892146033 cites W1989824843 @default.
- W2892146033 cites W1992813803 @default.
- W2892146033 cites W2000965529 @default.
- W2892146033 cites W2001093038 @default.
- W2892146033 cites W2002210828 @default.
- W2892146033 cites W2007034244 @default.
- W2892146033 cites W2007453010 @default.
- W2892146033 cites W2035023552 @default.
- W2892146033 cites W2054200572 @default.
- W2892146033 cites W2074081460 @default.
- W2892146033 cites W2077468928 @default.
- W2892146033 cites W2082498537 @default.
- W2892146033 cites W2102212449 @default.
- W2892146033 cites W2103861118 @default.
- W2892146033 cites W2107554012 @default.
- W2892146033 cites W2113992254 @default.
- W2892146033 cites W2114648309 @default.
- W2892146033 cites W2122007084 @default.
- W2892146033 cites W2123491442 @default.
- W2892146033 cites W2124836944 @default.
- W2892146033 cites W2127170862 @default.
- W2892146033 cites W2128152952 @default.
- W2892146033 cites W2135488666 @default.
- W2892146033 cites W2136786685 @default.
- W2892146033 cites W2154456419 @default.
- W2892146033 cites W2159482845 @default.
- W2892146033 cites W2173271778 @default.
- W2892146033 cites W2211442310 @default.
- W2892146033 cites W2237883872 @default.
- W2892146033 cites W2264058088 @default.
- W2892146033 cites W2285064633 @default.
- W2892146033 cites W2302280739 @default.
- W2892146033 cites W2319605272 @default.
- W2892146033 cites W2325500732 @default.
- W2892146033 cites W2486882743 @default.
- W2892146033 cites W2517794244 @default.
- W2892146033 cites W2549362566 @default.
- W2892146033 cites W2559797242 @default.
- W2892146033 cites W2560805344 @default.
- W2892146033 cites W2567031164 @default.
- W2892146033 cites W2583231967 @default.
- W2892146033 cites W2604315141 @default.
- W2892146033 cites W2618639421 @default.
- W2892146033 cites W2747841296 @default.
- W2892146033 cites W2951964571 @default.
- W2892146033 cites W2952877818 @default.
- W2892146033 cites W30428193 @default.
- W2892146033 cites W4211091012 @default.
- W2892146033 cites W4237335579 @default.
- W2892146033 cites W4294216483 @default.
- W2892146033 cites W48248669 @default.
- W2892146033 doi "https://doi.org/10.1038/s41467-018-06222-0" @default.
- W2892146033 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6156584" @default.
- W2892146033 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30254269" @default.
- W2892146033 hasPublicationYear "2018" @default.
- W2892146033 type Work @default.
- W2892146033 sameAs 2892146033 @default.
- W2892146033 citedByCount "103" @default.
- W2892146033 countsByYear W28921460332019 @default.
- W2892146033 countsByYear W28921460332020 @default.
- W2892146033 countsByYear W28921460332021 @default.
- W2892146033 countsByYear W28921460332022 @default.
- W2892146033 countsByYear W28921460332023 @default.
- W2892146033 crossrefType "journal-article" @default.
- W2892146033 hasAuthorship W2892146033A5014686940 @default.
- W2892146033 hasAuthorship W2892146033A5020876132 @default.
- W2892146033 hasAuthorship W2892146033A5038362399 @default.
- W2892146033 hasAuthorship W2892146033A5050517394 @default.
- W2892146033 hasAuthorship W2892146033A5057009272 @default.
- W2892146033 hasAuthorship W2892146033A5060552570 @default.
- W2892146033 hasAuthorship W2892146033A5070853840 @default.
- W2892146033 hasAuthorship W2892146033A5088751229 @default.
- W2892146033 hasBestOaLocation W28921460331 @default.
- W2892146033 hasConcept C118552586 @default.
- W2892146033 hasConcept C142724271 @default.
- W2892146033 hasConcept C148762608 @default.