Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892156748> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2892156748 abstract "e18158 Background: Diabetes is associated with adverse cancer outcomes. However, the effect of hyperglycemia independent of diabetes is unclear. Here we report on a meta-analysis exploring the effect of hyperglycemia on outcomes of solid tumors, and the influence of clinical factors on this association. Methods: A systematic search of electronic databases identified publications exploring the effect of hyperglycemia on overall (OS), disease-free (DFS) or progression-free survival (PFS). Definitions of hyperglycemia (fasting blood glucose, random blood glucose or HbA1c) and cut-offs varied between studies. Data from studies reporting a hazard ratio (HR) and 95% confidence interval (CI) or a p -value were pooled in a meta-analysis using generic inverse-variance and random effects modeling. Subgroup analyses were conducted based on method of hyperglycemia measurement (HbA1c, other) and tumor stage (early, advanced, mixed). Meta-regression was performed to evaluate the influence of clinical characteristics including baseline diabetes status on the HR for OS. All statistical tests were two-sided. Results: Eight studies comprising a total of 4342 patients were included. All studies reported HRs for OS. Two studies reported DFS outcomes, and two reported PFS. Hyperglycemia was associated with worse OS (HR 2.07, 95% CI = 1.70 - 2.52; P < 0.001) and DFS (HR 1.61, 95% CI = 1.04 - 2.49; P < 0.001), but did not decrease PFS (HR 1.08, 95% CI = 0.72 - 1.62; P = 0.71). The association with worse OS maintained in subgroups based on method of hyperglycemia measurement (subgroup difference P = 0.65) and tumor stage ( P= 0.47). Meta-regression analyses did not identify any factors significantly altering the magnitude of association between hyperglycemia and OS (see Table). Conclusions: Hyperglycemia is associated with adverse OS and DFS in patients with cancer, and the therapeutic role of optimal glycemic control warrants further investigation. [Table: see text]" @default.
- W2892156748 created "2018-09-27" @default.
- W2892156748 creator A5004107294 @default.
- W2892156748 creator A5022163984 @default.
- W2892156748 creator A5029892704 @default.
- W2892156748 creator A5034990400 @default.
- W2892156748 creator A5048283327 @default.
- W2892156748 creator A5074810713 @default.
- W2892156748 date "2017-05-20" @default.
- W2892156748 modified "2023-09-22" @default.
- W2892156748 title "Hyperglycemia and survival in solid tumors: A systematic review and meta-analysis." @default.
- W2892156748 doi "https://doi.org/10.1200/jco.2017.35.15_suppl.e18158" @default.
- W2892156748 hasPublicationYear "2017" @default.
- W2892156748 type Work @default.
- W2892156748 sameAs 2892156748 @default.
- W2892156748 citedByCount "0" @default.
- W2892156748 crossrefType "journal-article" @default.
- W2892156748 hasAuthorship W2892156748A5004107294 @default.
- W2892156748 hasAuthorship W2892156748A5022163984 @default.
- W2892156748 hasAuthorship W2892156748A5029892704 @default.
- W2892156748 hasAuthorship W2892156748A5034990400 @default.
- W2892156748 hasAuthorship W2892156748A5048283327 @default.
- W2892156748 hasAuthorship W2892156748A5074810713 @default.
- W2892156748 hasConcept C121608353 @default.
- W2892156748 hasConcept C126322002 @default.
- W2892156748 hasConcept C143998085 @default.
- W2892156748 hasConcept C17744445 @default.
- W2892156748 hasConcept C189708586 @default.
- W2892156748 hasConcept C199539241 @default.
- W2892156748 hasConcept C2779473830 @default.
- W2892156748 hasConcept C2993640289 @default.
- W2892156748 hasConcept C71924100 @default.
- W2892156748 hasConcept C95190672 @default.
- W2892156748 hasConceptScore W2892156748C121608353 @default.
- W2892156748 hasConceptScore W2892156748C126322002 @default.
- W2892156748 hasConceptScore W2892156748C143998085 @default.
- W2892156748 hasConceptScore W2892156748C17744445 @default.
- W2892156748 hasConceptScore W2892156748C189708586 @default.
- W2892156748 hasConceptScore W2892156748C199539241 @default.
- W2892156748 hasConceptScore W2892156748C2779473830 @default.
- W2892156748 hasConceptScore W2892156748C2993640289 @default.
- W2892156748 hasConceptScore W2892156748C71924100 @default.
- W2892156748 hasConceptScore W2892156748C95190672 @default.
- W2892156748 hasLocation W28921567481 @default.
- W2892156748 hasOpenAccess W2892156748 @default.
- W2892156748 hasPrimaryLocation W28921567481 @default.
- W2892156748 hasRelatedWork W1981007820 @default.
- W2892156748 hasRelatedWork W2092589146 @default.
- W2892156748 hasRelatedWork W2108025840 @default.
- W2892156748 hasRelatedWork W2128848838 @default.
- W2892156748 hasRelatedWork W2168678310 @default.
- W2892156748 hasRelatedWork W2327172715 @default.
- W2892156748 hasRelatedWork W2329089373 @default.
- W2892156748 hasRelatedWork W2344249756 @default.
- W2892156748 hasRelatedWork W2346298590 @default.
- W2892156748 hasRelatedWork W2951974399 @default.
- W2892156748 hasRelatedWork W2952372583 @default.
- W2892156748 hasRelatedWork W2960951338 @default.
- W2892156748 hasRelatedWork W2963646943 @default.
- W2892156748 hasRelatedWork W2974403716 @default.
- W2892156748 hasRelatedWork W2982207174 @default.
- W2892156748 hasRelatedWork W2983701642 @default.
- W2892156748 hasRelatedWork W2987450836 @default.
- W2892156748 hasRelatedWork W3013611021 @default.
- W2892156748 hasRelatedWork W3032840466 @default.
- W2892156748 hasRelatedWork W3213713152 @default.
- W2892156748 isParatext "false" @default.
- W2892156748 isRetracted "false" @default.
- W2892156748 magId "2892156748" @default.
- W2892156748 workType "article" @default.