FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892163605> ?p ?o ?g. }

• W2892163605 endingPage "250" @default.
• W2892163605 startingPage "245" @default.
• W2892163605 abstract "Sialadenitis is an inflammatory condition affecting the salivary glands including the parotid, submandibular, and sublingual glands. There are several different types of sialadenitis, each with different sites of predilection. However, the pathogenic mechanism underlying the tissue specificity of sialadenitis is largely unknown. TRAF6 is a cytoplasmic adaptor protein that is necessary for the activation of dendritic cells in response to Toll-like receptor ligands, thereby regulating innate immune responses. We previously demonstrated that T cell-specific TRAF6-deficient mice (TRAF6ΔT mice) spontaneously develop systemic inflammatory disease. Here, we show that salivary secretion is reduced in TRAF6ΔT mice due to sialadenitis that occurs in the parotid and submandibular glands, but not the sublingual glands. Consistent with pathological findings, both CD4+ and CD8+ T cells predominantly infiltrated the submandibular glands; however, sublingual infiltration was rare in TRAF6ΔT mice. The TH1 cytokine IFN-γ, the TH1 cell attractant chemokine CCL2, and its cognate receptor CCR2 were upregulated concomitantly in both the submandibular and sublingual glands. Interestingly, the TH17 cell attractant chemokine CCL20 and its cognate receptor CCR6 were selectively increased in the submandibular glands, but not in the sublingual glands of TRAF6ΔT mice. Thus, the expression of TRAF6 in T cells might be implicated in tissue-specific sialadenitis by regulating the chemokine-chemokine receptor system." @default.
• W2892163605 created "2018-09-27" @default.
• W2892163605 creator A5011832640 @default.
• W2892163605 creator A5016229035 @default.
• W2892163605 creator A5026515124 @default.
• W2892163605 creator A5039238305 @default.
• W2892163605 creator A5045319991 @default.
• W2892163605 creator A5049122717 @default.
• W2892163605 creator A5050035803 @default.
• W2892163605 creator A5056246081 @default.
• W2892163605 creator A5061369503 @default.
• W2892163605 creator A5063617663 @default.
• W2892163605 creator A5074810793 @default.
• W2892163605 creator A5075016283 @default.
• W2892163605 creator A5081065303 @default.
• W2892163605 creator A5084897073 @default.
• W2892163605 date "2018-09-01" @default.
• W2892163605 modified "2023-09-23" @default.
• W2892163605 title "Autoimmune sialadenitis is associated with the upregulation of chemokine/chemokine receptor pairs in T cell-specific TRAF6-deficient mice" @default.
• W2892163605 cites W1789330480 @default.
• W2892163605 cites W1933465244 @default.
• W2892163605 cites W1969015127 @default.
• W2892163605 cites W1970181089 @default.
• W2892163605 cites W1972755311 @default.
• W2892163605 cites W1979221327 @default.
• W2892163605 cites W1986544445 @default.
• W2892163605 cites W2005659566 @default.
• W2892163605 cites W2006216142 @default.
• W2892163605 cites W2021861978 @default.
• W2892163605 cites W2061631515 @default.
• W2892163605 cites W2088095133 @default.
• W2892163605 cites W2102628016 @default.
• W2892163605 cites W2105297714 @default.
• W2892163605 cites W2113623657 @default.
• W2892163605 cites W2117340681 @default.
• W2892163605 cites W2124671153 @default.
• W2892163605 cites W2133961805 @default.
• W2892163605 cites W2139867864 @default.
• W2892163605 cites W2141300514 @default.
• W2892163605 cites W2145194114 @default.
• W2892163605 cites W2153960708 @default.
• W2892163605 cites W2297116035 @default.
• W2892163605 cites W4247134984 @default.
• W2892163605 cites W4255734816 @default.
• W2892163605 doi "https://doi.org/10.1016/j.bbrc.2018.08.162" @default.
• W2892163605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30190125" @default.
• W2892163605 hasPublicationYear "2018" @default.
• W2892163605 type Work @default.
• W2892163605 sameAs 2892163605 @default.
• W2892163605 citedByCount "2" @default.
• W2892163605 countsByYear W28921636052020 @default.
• W2892163605 countsByYear W28921636052021 @default.
• W2892163605 crossrefType "journal-article" @default.
• W2892163605 hasAuthorship W2892163605A5011832640 @default.
• W2892163605 hasAuthorship W2892163605A5016229035 @default.
• W2892163605 hasAuthorship W2892163605A5026515124 @default.
• W2892163605 hasAuthorship W2892163605A5039238305 @default.
• W2892163605 hasAuthorship W2892163605A5045319991 @default.
• W2892163605 hasAuthorship W2892163605A5049122717 @default.
• W2892163605 hasAuthorship W2892163605A5050035803 @default.
• W2892163605 hasAuthorship W2892163605A5056246081 @default.
• W2892163605 hasAuthorship W2892163605A5061369503 @default.
• W2892163605 hasAuthorship W2892163605A5063617663 @default.
• W2892163605 hasAuthorship W2892163605A5074810793 @default.
• W2892163605 hasAuthorship W2892163605A5075016283 @default.
• W2892163605 hasAuthorship W2892163605A5081065303 @default.
• W2892163605 hasAuthorship W2892163605A5084897073 @default.
• W2892163605 hasConcept C12823836 @default.
• W2892163605 hasConcept C13373296 @default.
• W2892163605 hasConcept C134018914 @default.
• W2892163605 hasConcept C142724271 @default.
• W2892163605 hasConcept C167464567 @default.
• W2892163605 hasConcept C185592680 @default.
• W2892163605 hasConcept C203014093 @default.
• W2892163605 hasConcept C206615009 @default.
• W2892163605 hasConcept C2778808962 @default.
• W2892163605 hasConcept C2778937882 @default.
• W2892163605 hasConcept C2780266248 @default.
• W2892163605 hasConcept C71924100 @default.
• W2892163605 hasConcept C83360876 @default.
• W2892163605 hasConcept C86803240 @default.
• W2892163605 hasConcept C8891405 @default.
• W2892163605 hasConcept C94205230 @default.
• W2892163605 hasConceptScore W2892163605C12823836 @default.
• W2892163605 hasConceptScore W2892163605C13373296 @default.
• W2892163605 hasConceptScore W2892163605C134018914 @default.
• W2892163605 hasConceptScore W2892163605C142724271 @default.
• W2892163605 hasConceptScore W2892163605C167464567 @default.
• W2892163605 hasConceptScore W2892163605C185592680 @default.
• W2892163605 hasConceptScore W2892163605C203014093 @default.
• W2892163605 hasConceptScore W2892163605C206615009 @default.
• W2892163605 hasConceptScore W2892163605C2778808962 @default.
• W2892163605 hasConceptScore W2892163605C2778937882 @default.
• W2892163605 hasConceptScore W2892163605C2780266248 @default.
• W2892163605 hasConceptScore W2892163605C71924100 @default.
• W2892163605 hasConceptScore W2892163605C83360876 @default.
• W2892163605 hasConceptScore W2892163605C86803240 @default.
• W2892163605 hasConceptScore W2892163605C8891405 @default.

• next