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- W2892169790 abstract "Impulse control disorders (ICDs) and other related behaviors, such as punding and dopamine dysregulation syndrome, are frequent yet underrecognized non-motor complications of dopamine replacement therapy (DRT) in Parkinson's disease (PD); they can also have a major negative impact on quality of life. They result from complex interactions between a given individual's predispositions, non-physiological dopaminergic stimulation and PD pathology. Also, sensitization of the mesocorticolimbic pathway, reflected by the psychotropic effects of dopaminergic treatment, plays a crucial role in the emergence of these addictive behaviors. While early detection of changes in behavior, less use of dopamine agonists (DA) that have a relative selectivity for mesocorticolimbic dopamine receptors, and fractionation of levodopa dosages to avoid non-physiological pulsatile stimulation of dopamine receptors are key strategies in the management of this hyperdopaminergic behavioral spectrum, other complementary approaches are also addressed in this review." @default.
- W2892169790 created "2018-09-27" @default.
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- W2892169790 date "2018-11-01" @default.
- W2892169790 modified "2023-09-23" @default.
- W2892169790 title "Hyperdopaminergic behavioral spectrum in Parkinson's disease: A review" @default.
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- W2892169790 doi "https://doi.org/10.1016/j.neurol.2018.07.005" @default.
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