FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892170508> ?p ?o ?g. }

• W2892170508 endingPage "2506" @default.
• W2892170508 startingPage "2494" @default.
• W2892170508 abstract "In clinical trials, inhibition of cholesteryl ester transfer protein (CETP) raises HDL cholesterol levels but does not robustly improve cardiovascular outcomes. Approximately two-thirds of trial participants are obese. Lower plasma CETP activity is associated with increased cardiovascular risk in human studies, and protective aspects of CETP have been observed in mice fed a high-fat diet (HFD) with regard to metabolic outcomes. To define whether CETP inhibition has different effects depending on the presence of obesity, we performed short-term anacetrapib treatment in chow- and HFD-fed CETP transgenic mice. Anacetrapib raised HDL cholesterol and improved aspects of HDL functionality, including reverse cholesterol transport, and HDL’s antioxidative capacity in HFD-fed mice was better than in chow-fed mice. Anacetrapib worsened the anti-inflammatory capacity of HDL in HFD-fed mice. The HDL proteome was markedly different with anacetrapib treatment in HFD- versus chow-fed mice. Despite benefits on HDL, anacetrapib led to liver triglyceride accumulation and insulin resistance in HFD-fed mice. Overall, our results support a physiologic importance of CETP in protecting from fatty liver and demonstrate context selectivity of CETP inhibition that might be important in obese subjects." @default.
• W2892170508 created "2018-09-27" @default.
• W2892170508 creator A5001089571 @default.
• W2892170508 creator A5002368934 @default.
• W2892170508 creator A5026311622 @default.
• W2892170508 creator A5027393443 @default.
• W2892170508 creator A5034403861 @default.
• W2892170508 creator A5038687178 @default.
• W2892170508 creator A5039574585 @default.
• W2892170508 creator A5042782798 @default.
• W2892170508 creator A5057846302 @default.
• W2892170508 creator A5067797353 @default.
• W2892170508 creator A5073213559 @default.
• W2892170508 creator A5073893166 @default.
• W2892170508 date "2018-09-13" @default.
• W2892170508 modified "2023-10-14" @default.
• W2892170508 title "CETP Inhibition Improves HDL Function but Leads to Fatty Liver and Insulin Resistance in CETP-Expressing Transgenic Mice on a High-Fat Diet" @default.
• W2892170508 cites W1569311543 @default.
• W2892170508 cites W1969734540 @default.
• W2892170508 cites W1976347559 @default.
• W2892170508 cites W1988448764 @default.
• W2892170508 cites W1993577107 @default.
• W2892170508 cites W1995722781 @default.
• W2892170508 cites W1998091483 @default.
• W2892170508 cites W2000600725 @default.
• W2892170508 cites W2005016263 @default.
• W2892170508 cites W2012504949 @default.
• W2892170508 cites W2034850913 @default.
• W2892170508 cites W2036882688 @default.
• W2892170508 cites W2039776032 @default.
• W2892170508 cites W2041197131 @default.
• W2892170508 cites W2048760408 @default.
• W2892170508 cites W2052987579 @default.
• W2892170508 cites W2086731358 @default.
• W2892170508 cites W2090464684 @default.
• W2892170508 cites W2091505484 @default.
• W2892170508 cites W2103379494 @default.
• W2892170508 cites W2118825330 @default.
• W2892170508 cites W2129941946 @default.
• W2892170508 cites W2131257198 @default.
• W2892170508 cites W2131885674 @default.
• W2892170508 cites W2133677304 @default.
• W2892170508 cites W2135532774 @default.
• W2892170508 cites W2137113092 @default.
• W2892170508 cites W2141210634 @default.
• W2892170508 cites W2151833491 @default.
• W2892170508 cites W2152874974 @default.
• W2892170508 cites W2158057499 @default.
• W2892170508 cites W2159243445 @default.
• W2892170508 cites W2162638080 @default.
• W2892170508 cites W2163187036 @default.
• W2892170508 cites W2238569453 @default.
• W2892170508 cites W2405908973 @default.
• W2892170508 cites W2462046607 @default.
• W2892170508 cites W2462413218 @default.
• W2892170508 cites W2523568958 @default.
• W2892170508 cites W2616536890 @default.
• W2892170508 cites W2616548027 @default.
• W2892170508 cites W2762777606 @default.
• W2892170508 cites W2763860064 @default.
• W2892170508 cites W2781149841 @default.
• W2892170508 doi "https://doi.org/10.2337/db18-0474" @default.
• W2892170508 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6245220" @default.
• W2892170508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30213825" @default.
• W2892170508 hasPublicationYear "2018" @default.
• W2892170508 type Work @default.
• W2892170508 sameAs 2892170508 @default.
• W2892170508 citedByCount "20" @default.
• W2892170508 countsByYear W28921705082019 @default.
• W2892170508 countsByYear W28921705082020 @default.
• W2892170508 countsByYear W28921705082021 @default.
• W2892170508 countsByYear W28921705082022 @default.
• W2892170508 countsByYear W28921705082023 @default.
• W2892170508 crossrefType "journal-article" @default.
• W2892170508 hasAuthorship W2892170508A5001089571 @default.
• W2892170508 hasAuthorship W2892170508A5002368934 @default.
• W2892170508 hasAuthorship W2892170508A5026311622 @default.
• W2892170508 hasAuthorship W2892170508A5027393443 @default.
• W2892170508 hasAuthorship W2892170508A5034403861 @default.
• W2892170508 hasAuthorship W2892170508A5038687178 @default.
• W2892170508 hasAuthorship W2892170508A5039574585 @default.
• W2892170508 hasAuthorship W2892170508A5042782798 @default.
• W2892170508 hasAuthorship W2892170508A5057846302 @default.
• W2892170508 hasAuthorship W2892170508A5067797353 @default.
• W2892170508 hasAuthorship W2892170508A5073213559 @default.
• W2892170508 hasAuthorship W2892170508A5073893166 @default.
• W2892170508 hasBestOaLocation W28921705081 @default.
• W2892170508 hasConcept C102230213 @default.
• W2892170508 hasConcept C104317684 @default.
• W2892170508 hasConcept C110459506 @default.
• W2892170508 hasConcept C126322002 @default.
• W2892170508 hasConcept C134018914 @default.
• W2892170508 hasConcept C141035611 @default.
• W2892170508 hasConcept C151730666 @default.
• W2892170508 hasConcept C2777391703 @default.
• W2892170508 hasConcept C2778163477 @default.
• W2892170508 hasConcept C2778772119 @default.
• W2892170508 hasConcept C2778913445 @default.

• next