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• W2892190968 abstract "Abstract High expression of VEGFC predicts adverse prognosis in acute myeloid leukemia (AML). We therefore explored VEGFC-targeting efficacy as an AML therapy using a VEGFC mAb. VEGFC antibody therapy enforced myelocytic differentiation of clonal CD34+ AML blasts. Treatment of CD34+ AML blasts with the antibody reduced expansion potential by 30% to 50% and enhanced differentiation via FOXO3A suppression and inhibition of MAPK/ERK proliferative signals. VEGFC antibody therapy also accelerated leukemia cell differentiation in a systemic humanized AML mouse model. Collectively, these results define a regulatory function of VEGFC in CD34+ AML cell fate decisions via FOXO3A and serve as a new potential differentiation therapy for patients with AML. Significance: These findings reveal VEGFC targeting as a promising new differentiation therapy in AML. Cancer Res; 78(20); 5940–8. ©2018 AACR." @default.
• W2892190968 created "2018-09-27" @default.
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• W2892190968 date "2018-10-15" @default.
• W2892190968 modified "2023-10-02" @default.
• W2892190968 title "VEGFC Antibody Therapy Drives Differentiation of AML" @default.
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• W2892190968 doi "https://doi.org/10.1158/0008-5472.can-18-0250" @default.
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