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- W2892200679 endingPage "155" @default.
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- W2892200679 abstract "Systematic evolution of ligand by exponential enrichment (SELEX) is an efficient method used to isolate high-affinity single stranded oligonucleotides from a large random sequence pool. These SELEX-derived oligonucleotides named aptamer, can be selected against a broad spectrum of target molecules including proteins, cells, microorganisms and chemical compounds. Like antibodies, aptamers have a great potential in interacting with and binding to their targets through structural recognition and are therefore called chemical antibodies. However, aptamers offer advantages over antibodies including smaller size, better tissue penetration, higher thermal stability, lower immunogenicity, easier production, lower cost of synthesis and facilitated conjugation or modification with different functional moieties. Thus, aptamers represent an attractive substitution for protein antibodies in the fields of biomarker discovery, diagnosis, imaging and targeted therapy. Enormous interest in aptamer technology triggered the development of SELEX that has underwent numerous modifications since its introduction in 1990. This review will discuss the recent advances in SELEX methods and their advantages and limitations. Aptamer applications are also briefly outlined in this review." @default.
- W2892200679 created "2018-09-27" @default.
- W2892200679 creator A5015103898 @default.
- W2892200679 creator A5038783616 @default.
- W2892200679 creator A5039260981 @default.
- W2892200679 creator A5039339727 @default.
- W2892200679 creator A5040634721 @default.
- W2892200679 creator A5070602888 @default.
- W2892200679 creator A5085755111 @default.
- W2892200679 date "2018-11-01" @default.
- W2892200679 modified "2023-10-01" @default.
- W2892200679 title "SELEX methods on the road to protein targeting with nucleic acid aptamers" @default.
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