FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892204555> ?p ?o ?g. }

• W2892204555 abstract "The pathophysiology of atrial fibrillation (AF) is broad, with components related to the unique and diverse cellular electrophysiology of atrial myocytes, structural complexity, and heterogeneity of atrial tissue, and pronounced disease-associated remodeling of both cells and tissue. A major challenge for rational design of AF therapy, particularly pharmacotherapy, is integrating these multiscale characteristics to identify approaches that are both efficacious and independent of ventricular contraindications. Computational modeling has long been touted as a basis for achieving such integration in a rapid, economical, and scalable manner. However, computational pipelines for AF-specific drug screening are in their infancy, and while the field is progressing quite rapidly, major challenges remain before computational approaches can fill the role of workhorse in rational design of AF pharmacotherapies. In this review, we briefly detail the unique aspects of AF pathophysiology that determine requirements for compounds targeting AF rhythm control, with emphasis on delimiting mechanisms that promote AF triggers from those providing substrate or supporting reentry. We then describe modeling approaches that have been used to assess the outcomes of drugs acting on established AF targets, as well as on novel promising targets including the ultra-rapidly activating delayed rectifier potassium current, the acetylcholine-activated potassium current and the small conductance calcium-activated potassium channel. Finally, we describe how heterogeneity and variability are being incorporated into AF-specific models, and how these approaches are yielding novel insights into the basic physiology of disease, as well as aiding identification of the important molecular players in the complex AF etiology." @default.
• W2892204555 created "2018-09-27" @default.
• W2892204555 creator A5003483167 @default.
• W2892204555 creator A5018598045 @default.
• W2892204555 creator A5033213039 @default.
• W2892204555 creator A5037755067 @default.
• W2892204555 creator A5042739878 @default.
• W2892204555 creator A5062641668 @default.
• W2892204555 date "2018-09-04" @default.
• W2892204555 modified "2023-10-15" @default.
• W2892204555 title "Computational Modeling of Electrophysiology and Pharmacotherapy of Atrial Fibrillation: Recent Advances and Future Challenges" @default.
• W2892204555 cites W1480380319 @default.
• W2892204555 cites W1482350832 @default.
• W2892204555 cites W1485382552 @default.
• W2892204555 cites W1490359669 @default.
• W2892204555 cites W1519251370 @default.
• W2892204555 cites W1584858463 @default.
• W2892204555 cites W1590284881 @default.
• W2892204555 cites W1602987494 @default.
• W2892204555 cites W1711651084 @default.
• W2892204555 cites W1881989874 @default.
• W2892204555 cites W1930833808 @default.
• W2892204555 cites W1965139977 @default.
• W2892204555 cites W1966745421 @default.
• W2892204555 cites W1967857799 @default.
• W2892204555 cites W1968856255 @default.
• W2892204555 cites W1969111657 @default.
• W2892204555 cites W1972142091 @default.
• W2892204555 cites W1972682438 @default.
• W2892204555 cites W1973622981 @default.
• W2892204555 cites W1977293470 @default.
• W2892204555 cites W1979003439 @default.
• W2892204555 cites W1979588044 @default.
• W2892204555 cites W1980233139 @default.
• W2892204555 cites W1980369595 @default.
• W2892204555 cites W1984612072 @default.
• W2892204555 cites W1985148130 @default.
• W2892204555 cites W1985570405 @default.
• W2892204555 cites W1986285291 @default.
• W2892204555 cites W1988470888 @default.
• W2892204555 cites W1989313129 @default.
• W2892204555 cites W1990571474 @default.
• W2892204555 cites W1990628749 @default.
• W2892204555 cites W1991781357 @default.
• W2892204555 cites W1992891753 @default.
• W2892204555 cites W1993015362 @default.
• W2892204555 cites W1993534871 @default.
• W2892204555 cites W1995804845 @default.
• W2892204555 cites W1998730638 @default.
• W2892204555 cites W1999433956 @default.
• W2892204555 cites W2002439304 @default.
• W2892204555 cites W2003475749 @default.
• W2892204555 cites W2003487329 @default.
• W2892204555 cites W2003654791 @default.
• W2892204555 cites W20074729 @default.
• W2892204555 cites W2012279476 @default.
• W2892204555 cites W2012997924 @default.
• W2892204555 cites W2013025913 @default.
• W2892204555 cites W2013869728 @default.
• W2892204555 cites W2014843536 @default.
• W2892204555 cites W2017179259 @default.
• W2892204555 cites W2017896922 @default.
• W2892204555 cites W2018450313 @default.
• W2892204555 cites W2018879951 @default.
• W2892204555 cites W2021597262 @default.
• W2892204555 cites W2022178882 @default.
• W2892204555 cites W2024413305 @default.
• W2892204555 cites W2025238295 @default.
• W2892204555 cites W2027072899 @default.
• W2892204555 cites W2028415167 @default.
• W2892204555 cites W2031897378 @default.
• W2892204555 cites W2032037185 @default.
• W2892204555 cites W2032223051 @default.
• W2892204555 cites W2032367112 @default.
• W2892204555 cites W2032728769 @default.
• W2892204555 cites W2033704512 @default.
• W2892204555 cites W2033861216 @default.
• W2892204555 cites W2034943103 @default.
• W2892204555 cites W2036500140 @default.
• W2892204555 cites W2037847246 @default.
• W2892204555 cites W2038437324 @default.
• W2892204555 cites W2038498445 @default.
• W2892204555 cites W2038531964 @default.
• W2892204555 cites W2039978986 @default.
• W2892204555 cites W2040369353 @default.
• W2892204555 cites W2043623785 @default.
• W2892204555 cites W2044769457 @default.
• W2892204555 cites W2044933725 @default.
• W2892204555 cites W2045787555 @default.
• W2892204555 cites W2050184434 @default.
• W2892204555 cites W2051550066 @default.
• W2892204555 cites W2051822015 @default.
• W2892204555 cites W2055928084 @default.
• W2892204555 cites W2057046598 @default.
• W2892204555 cites W2057841956 @default.
• W2892204555 cites W2058813449 @default.
• W2892204555 cites W2061451182 @default.
• W2892204555 cites W2062105156 @default.
• W2892204555 cites W2064983993 @default.
• W2892204555 cites W2066274276 @default.

• next