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- W2892212727 abstract "The acquisition of new hosts conditions virus epidemiology and emergence; hence it is important to understand the mechanisms behind host range expansion. Experimental evolution studies have identified antagonistic pleiotropy and epistasis as genetic mechanisms that limit host range expansion, but studies from virus field populations are few. Here, we compare the performance of isolates of tobacco mild green mosaic virus from its reservoir host, Nicotiana glauca, and its new host, pepper, showing that acquisition of a new host was not followed by adaptation to it but was associated with a fitness loss in the original host. Analysis of mutations determining host-specific virus multiplication identified antagonistic pleiotropy, epistasis, and host-specific epistasis as mechanisms generating across-host fitness trade-offs that may prevent adaptation to pepper and cause a loss of fitness in N. glauca . Thus, mechanisms determining trade-offs, identified under experimental evolution, could also operate in the heterogeneous environment in which natural plant virus populations occur." @default.
- W2892212727 created "2018-09-27" @default.
- W2892212727 creator A5033371881 @default.
- W2892212727 creator A5043537545 @default.
- W2892212727 creator A5058857590 @default.
- W2892212727 date "2018-12-15" @default.
- W2892212727 modified "2023-10-18" @default.
- W2892212727 title "Analysis of Fitness Trade-Offs in the Host Range Expansion of an RNA Virus, Tobacco Mild Green Mosaic Virus" @default.
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- W2892212727 doi "https://doi.org/10.1128/jvi.01268-18" @default.
- W2892212727 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6258955" @default.
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- W2892212727 hasPublicationYear "2018" @default.
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