FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892213156> ?p ?o ?g. }

• W2892213156 endingPage "63" @default.
• W2892213156 startingPage "60" @default.
• W2892213156 abstract "High low-density-lipoprotein cholesterol (LDL-C) is routinely described as the main cause of cardiovascular disease (CVD) in familial hypercholesterolemia (FH). However, numerous observations are in conflict with Bradford Hill’s criteria for causality: a) degree of atherosclerosis is not associated with LDL-C; b) on average the life span of people with FH is about the same as for other people; c) LDL-C of people with FH without CVD is almost as high as in FH patients of the same age with CVD; and d) questionable benefit or none at all have been achieved in the controlled, randomized cholesterol-lowering trials that have included FH individuals only. Obviously, those individuals with FH who suffer from CVD may have inherited other and more important risk factors of CVD than high LDL-C. In accordance, several studies of FH individuals have shown that various coagulation factors may cause CVD. Equally, some non-FH members of an FH kindred with early CVD, have been found to suffer from early CVD as well. Cholesterol-lowering has only been successful in an animal experiment by using probucol, which has anticoagulant effects as well. We conclude that systematic studies of all kinds of risk factors among FH individuals are urgently required, because today millions of people with FH are treated with statins, the benefit of which in FH is unproven, and which have many serious side effects. We predict that treatment of FH individuals with elevated coagulation factors with anticoagulative drugs is more effective than statin treatment alone." @default.
• W2892213156 created "2018-09-27" @default.
• W2892213156 creator A5014907456 @default.
• W2892213156 creator A5038762107 @default.
• W2892213156 creator A5069664790 @default.
• W2892213156 creator A5085767822 @default.
• W2892213156 date "2018-12-01" @default.
• W2892213156 modified "2023-09-25" @default.
• W2892213156 title "Inborn coagulation factors are more important cardiovascular risk factors than high LDL-cholesterol in familial hypercholesterolemia" @default.
• W2892213156 cites W1568390176 @default.
• W2892213156 cites W1963968194 @default.
• W2892213156 cites W1969417111 @default.
• W2892213156 cites W1976162674 @default.
• W2892213156 cites W1988162176 @default.
• W2892213156 cites W2001328643 @default.
• W2892213156 cites W2007790950 @default.
• W2892213156 cites W2013595456 @default.
• W2892213156 cites W2015546021 @default.
• W2892213156 cites W2018005256 @default.
• W2892213156 cites W2058264208 @default.
• W2892213156 cites W2068147673 @default.
• W2892213156 cites W2077357940 @default.
• W2892213156 cites W2079473824 @default.
• W2892213156 cites W2087122344 @default.
• W2892213156 cites W2092128562 @default.
• W2892213156 cites W2094603538 @default.
• W2892213156 cites W2104487964 @default.
• W2892213156 cites W2119475560 @default.
• W2892213156 cites W2120289695 @default.
• W2892213156 cites W2120692091 @default.
• W2892213156 cites W2123704730 @default.
• W2892213156 cites W2133454964 @default.
• W2892213156 cites W2141210634 @default.
• W2892213156 cites W2141259094 @default.
• W2892213156 cites W2147346175 @default.
• W2892213156 cites W2147446436 @default.
• W2892213156 cites W2150982331 @default.
• W2892213156 cites W2161507199 @default.
• W2892213156 cites W2319045997 @default.
• W2892213156 cites W2329533302 @default.
• W2892213156 cites W2337077716 @default.
• W2892213156 cites W2418078838 @default.
• W2892213156 cites W2483885489 @default.
• W2892213156 cites W2519905430 @default.
• W2892213156 cites W4249898731 @default.
• W2892213156 cites W4292069677 @default.
• W2892213156 cites W4301101845 @default.
• W2892213156 doi "https://doi.org/10.1016/j.mehy.2018.09.019" @default.
• W2892213156 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30396495" @default.
• W2892213156 hasPublicationYear "2018" @default.
• W2892213156 type Work @default.
• W2892213156 sameAs 2892213156 @default.
• W2892213156 citedByCount "15" @default.
• W2892213156 countsByYear W28922131562019 @default.
• W2892213156 countsByYear W28922131562020 @default.
• W2892213156 countsByYear W28922131562021 @default.
• W2892213156 countsByYear W28922131562022 @default.
• W2892213156 countsByYear W28922131562023 @default.
• W2892213156 crossrefType "journal-article" @default.
• W2892213156 hasAuthorship W2892213156A5014907456 @default.
• W2892213156 hasAuthorship W2892213156A5038762107 @default.
• W2892213156 hasAuthorship W2892213156A5069664790 @default.
• W2892213156 hasAuthorship W2892213156A5085767822 @default.
• W2892213156 hasConcept C126322002 @default.
• W2892213156 hasConcept C2776167589 @default.
• W2892213156 hasConcept C2778163477 @default.
• W2892213156 hasConcept C2779120738 @default.
• W2892213156 hasConcept C2779134260 @default.
• W2892213156 hasConcept C2909478654 @default.
• W2892213156 hasConcept C71924100 @default.
• W2892213156 hasConceptScore W2892213156C126322002 @default.
• W2892213156 hasConceptScore W2892213156C2776167589 @default.
• W2892213156 hasConceptScore W2892213156C2778163477 @default.
• W2892213156 hasConceptScore W2892213156C2779120738 @default.
• W2892213156 hasConceptScore W2892213156C2779134260 @default.
• W2892213156 hasConceptScore W2892213156C2909478654 @default.
• W2892213156 hasConceptScore W2892213156C71924100 @default.
• W2892213156 hasLocation W28922131561 @default.
• W2892213156 hasLocation W28922131562 @default.
• W2892213156 hasOpenAccess W2892213156 @default.
• W2892213156 hasPrimaryLocation W28922131561 @default.
• W2892213156 hasRelatedWork W151054917 @default.
• W2892213156 hasRelatedWork W1988735096 @default.
• W2892213156 hasRelatedWork W1997858206 @default.
• W2892213156 hasRelatedWork W2012869343 @default.
• W2892213156 hasRelatedWork W2072092506 @default.
• W2892213156 hasRelatedWork W2465930461 @default.
• W2892213156 hasRelatedWork W2582768312 @default.
• W2892213156 hasRelatedWork W2607498983 @default.
• W2892213156 hasRelatedWork W387832104 @default.
• W2892213156 hasRelatedWork W4366685369 @default.
• W2892213156 hasVolume "121" @default.
• W2892213156 isParatext "false" @default.
• W2892213156 isRetracted "false" @default.
• W2892213156 magId "2892213156" @default.
• W2892213156 workType "article" @default.