Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892216701> ?p ?o ?g. }
- W2892216701 abstract "Influenza A virus is a widespread pathogen that affects both humans and a variety of animal species, causing regular epidemics and sporadic pandemics, with major public health and economic consequences. A better understanding of virus biology is therefore important. The primary control measure is vaccination, which for humans mostly relies on antigens produced in eggs from PR8-based viruses bearing the glycoprotein genes of interest. However, not all reassortants replicate well enough to supply sufficient virus antigen for demand. The significance of our research lies in identifying that mutation of the PA-X gene in the PR8 strain of virus can improve antigen yield, potentially by decreasing the pathogenicity of the virus in embryonated eggs." @default.
- W2892216701 created "2018-09-27" @default.
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- W2892216701 date "2019-01-15" @default.
- W2892216701 modified "2023-10-15" @default.
- W2892216701 title "Mutation of Influenza A Virus PA-X Decreases Pathogenicity in Chicken Embryos and Can Increase the Yield of Reassortant Candidate Vaccine Viruses" @default.
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- W2892216701 doi "https://doi.org/10.1128/jvi.01551-18" @default.
- W2892216701 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6321911" @default.
- W2892216701 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30381488" @default.
- W2892216701 hasPublicationYear "2019" @default.
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