FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892218441> ?p ?o ?g. }

• W2892218441 abstract "Antibody drug conjugates (ADCs) are increasingly employed as novel targeted therapies. Antibody drug conjugates combine the exquisite selectivity of targeted antibodies and the high potency of small-molecule drugs with the aim of achieving durable responses in patients. As application of highly potent small-molecule drugs can be limited by their undesirable toxicity, targeted delivery of highly potent small-molecule drugs to specific cells is intended at expanding the therapeutic window for the payload in the clinical setting. Critical parameters for design and selection of the antibody, target, and payload have been discussed in an earlier article (Sadekar et al., AAPS J 17: 828–36; 2015). Here, we have attempted to address some of the key translational topics critical for early development of this class of therapeutic. As anticipated, a successful transition of ADCs into the clinic will be highly dependent on effective translation of critical attributes governing exposure–response relationships across species." @default.
• W2892218441 created "2018-09-27" @default.
• W2892218441 creator A5016956318 @default.
• W2892218441 creator A5017526947 @default.
• W2892218441 creator A5077099374 @default.
• W2892218441 creator A5082665065 @default.
• W2892218441 date "2018-01-01" @default.
• W2892218441 modified "2023-09-26" @default.
• W2892218441 title "Antibody Drug Conjugates: Translational Considerations" @default.
• W2892218441 cites W1507835484 @default.
• W2892218441 cites W1968856619 @default.
• W2892218441 cites W1975553571 @default.
• W2892218441 cites W1981720428 @default.
• W2892218441 cites W1984226607 @default.
• W2892218441 cites W2000749669 @default.
• W2892218441 cites W2021621347 @default.
• W2892218441 cites W2045892715 @default.
• W2892218441 cites W2050427803 @default.
• W2892218441 cites W2061417092 @default.
• W2892218441 cites W2087785208 @default.
• W2892218441 cites W2088374507 @default.
• W2892218441 cites W2094540897 @default.
• W2892218441 cites W2112311127 @default.
• W2892218441 cites W2124514746 @default.
• W2892218441 cites W2139343978 @default.
• W2892218441 cites W2141807485 @default.
• W2892218441 cites W2150244588 @default.
• W2892218441 cites W2156032761 @default.
• W2892218441 cites W2323416021 @default.
• W2892218441 cites W381718880 @default.
• W2892218441 cites W2483022615 @default.
• W2892218441 doi "https://doi.org/10.1007/978-981-13-0496-5_10" @default.
• W2892218441 hasPublicationYear "2018" @default.
• W2892218441 type Work @default.
• W2892218441 sameAs 2892218441 @default.
• W2892218441 citedByCount "0" @default.
• W2892218441 crossrefType "book-chapter" @default.
• W2892218441 hasAuthorship W2892218441A5016956318 @default.
• W2892218441 hasAuthorship W2892218441A5017526947 @default.
• W2892218441 hasAuthorship W2892218441A5077099374 @default.
• W2892218441 hasAuthorship W2892218441A5082665065 @default.
• W2892218441 hasConcept C134066672 @default.
• W2892218441 hasConcept C134306372 @default.
• W2892218441 hasConcept C158379750 @default.
• W2892218441 hasConcept C159654299 @default.
• W2892218441 hasConcept C161624437 @default.
• W2892218441 hasConcept C185592680 @default.
• W2892218441 hasConcept C197336794 @default.
• W2892218441 hasConcept C202751555 @default.
• W2892218441 hasConcept C203014093 @default.
• W2892218441 hasConcept C2780035454 @default.
• W2892218441 hasConcept C31258907 @default.
• W2892218441 hasConcept C33923547 @default.
• W2892218441 hasConcept C41008148 @default.
• W2892218441 hasConcept C55493867 @default.
• W2892218441 hasConcept C57992300 @default.
• W2892218441 hasConcept C60644358 @default.
• W2892218441 hasConcept C70721500 @default.
• W2892218441 hasConcept C71924100 @default.
• W2892218441 hasConcept C74187038 @default.
• W2892218441 hasConcept C86803240 @default.
• W2892218441 hasConcept C98274493 @default.
• W2892218441 hasConceptScore W2892218441C134066672 @default.
• W2892218441 hasConceptScore W2892218441C134306372 @default.
• W2892218441 hasConceptScore W2892218441C158379750 @default.
• W2892218441 hasConceptScore W2892218441C159654299 @default.
• W2892218441 hasConceptScore W2892218441C161624437 @default.
• W2892218441 hasConceptScore W2892218441C185592680 @default.
• W2892218441 hasConceptScore W2892218441C197336794 @default.
• W2892218441 hasConceptScore W2892218441C202751555 @default.
• W2892218441 hasConceptScore W2892218441C203014093 @default.
• W2892218441 hasConceptScore W2892218441C2780035454 @default.
• W2892218441 hasConceptScore W2892218441C31258907 @default.
• W2892218441 hasConceptScore W2892218441C33923547 @default.
• W2892218441 hasConceptScore W2892218441C41008148 @default.
• W2892218441 hasConceptScore W2892218441C55493867 @default.
• W2892218441 hasConceptScore W2892218441C57992300 @default.
• W2892218441 hasConceptScore W2892218441C60644358 @default.
• W2892218441 hasConceptScore W2892218441C70721500 @default.
• W2892218441 hasConceptScore W2892218441C71924100 @default.
• W2892218441 hasConceptScore W2892218441C74187038 @default.
• W2892218441 hasConceptScore W2892218441C86803240 @default.
• W2892218441 hasConceptScore W2892218441C98274493 @default.
• W2892218441 hasLocation W28922184411 @default.
• W2892218441 hasOpenAccess W2892218441 @default.
• W2892218441 hasPrimaryLocation W28922184411 @default.
• W2892218441 hasRelatedWork W1572604377 @default.
• W2892218441 hasRelatedWork W1985335053 @default.
• W2892218441 hasRelatedWork W1997299931 @default.
• W2892218441 hasRelatedWork W2018773179 @default.
• W2892218441 hasRelatedWork W2032815757 @default.
• W2892218441 hasRelatedWork W2051303198 @default.
• W2892218441 hasRelatedWork W2073373556 @default.
• W2892218441 hasRelatedWork W2153170040 @default.
• W2892218441 hasRelatedWork W2268820401 @default.
• W2892218441 hasRelatedWork W2380539881 @default.
• W2892218441 hasRelatedWork W2598567848 @default.
• W2892218441 hasRelatedWork W2754547617 @default.
• W2892218441 hasRelatedWork W2810578520 @default.
• W2892218441 hasRelatedWork W2909135501 @default.

• next