FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892226813> ?p ?o ?g. }

• W2892226813 endingPage "e5538" @default.
• W2892226813 startingPage "e5538" @default.
• W2892226813 abstract "Sepsis remains a major problem in intensive care medicine. It is often accompanied by coagulopathies, leading to thrombotic occlusion of small vessels with subsequent organ damage and even fatal multi-organ failure. Prediction of the clinical course and outcome-especially in the heterogeneous group of pediatric patients-is difficult. Antithrombin, as an endogenous anticoagulant enzyme with anti-inflammatory properties, plays a central role in controling coagulation and infections. We investigated the relationship between antithrombin levels and organ failure as well as mortality in pediatric patients with sepsis.Data from 164 patients under the age of 18, diagnosed with sepsis, were retrospectively reviewed. Antithrombin levels were recorded three days before to three days after peak C-reactive protein to correlate antithrombin levels with inflammatory activity. Using the concept of developmental haemostasis, patients were divided into groups <1 yr and ≥1 yr of age.In both age groups, survivors had significantly higher levels of antithrombin than did deceased patients. An optimal threshold level for antithrombin was calculated by ROC analysis for survival: 41.5% (<1 yr) and 67.5% (≥1 yr). The mortality rate above this level was 3.3% (<1 yr) and 9.5% (≥1 yr), and below this level 41.7% (<1 yr) and 32.2% (≥1 yr); OR 18.8 (1.74 to 1005.02), p = 0.0047, and OR 4.46 (1.54 to 14.89), p = 0.003. In children <1 yr with antithrombin levels <41.5% the rate of respiratory failure (66.7%) was significantly higher than in patients with antithrombin levels above this threshold level (23.3%), OR 6.23 (1.23 to 37.81), p = 0.0132. In children ≥1 yr, both liver failure (20.3% vs 1.6%, OR 15.55 (2.16 to 685.01), p = 0.0008) and a dysfunctional intestinal tract (16.9% vs 4.8%, OR 4.04 (0.97 to 24.08), p = 0.0395) occurred more frequently above the antithrombin threshold level of 67.5%.In pediatric septic patients, significantly increased mortality and levels of organ failure were found below an age-dependent antithrombin threshold level. Antithrombin could be useful as a prognostic marker for survival and occurrence of organ failure in pediatric sepsis." @default.
• W2892226813 created "2018-09-27" @default.
• W2892226813 creator A5001095928 @default.
• W2892226813 creator A5002002730 @default.
• W2892226813 creator A5002705904 @default.
• W2892226813 creator A5013616292 @default.
• W2892226813 creator A5014023833 @default.
• W2892226813 creator A5036016244 @default.
• W2892226813 creator A5059080067 @default.
• W2892226813 creator A5073540456 @default.
• W2892226813 date "2018-09-05" @default.
• W2892226813 modified "2023-10-16" @default.
• W2892226813 title "Antithrombin deficiency is associated with mortality and impaired organ function in septic pediatric patients: a retrospective study" @default.
• W2892226813 cites W104552217 @default.
• W2892226813 cites W1523598805 @default.
• W2892226813 cites W1576352249 @default.
• W2892226813 cites W1593139778 @default.
• W2892226813 cites W159659659 @default.
• W2892226813 cites W1599029725 @default.
• W2892226813 cites W16951305 @default.
• W2892226813 cites W1922984966 @default.
• W2892226813 cites W1966951186 @default.
• W2892226813 cites W1981074654 @default.
• W2892226813 cites W1985664799 @default.
• W2892226813 cites W1993916872 @default.
• W2892226813 cites W2002013932 @default.
• W2892226813 cites W2002329154 @default.
• W2892226813 cites W2002495916 @default.
• W2892226813 cites W2005723966 @default.
• W2892226813 cites W2016777338 @default.
• W2892226813 cites W2017182484 @default.
• W2892226813 cites W2017401577 @default.
• W2892226813 cites W2018745526 @default.
• W2892226813 cites W2036279349 @default.
• W2892226813 cites W2036474812 @default.
• W2892226813 cites W2037516773 @default.
• W2892226813 cites W2037917480 @default.
• W2892226813 cites W2039462257 @default.
• W2892226813 cites W2049927822 @default.
• W2892226813 cites W2053093783 @default.
• W2892226813 cites W2054938569 @default.
• W2892226813 cites W2056261557 @default.
• W2892226813 cites W2059243076 @default.
• W2892226813 cites W2059243750 @default.
• W2892226813 cites W2067423028 @default.
• W2892226813 cites W2070051187 @default.
• W2892226813 cites W2071062978 @default.
• W2892226813 cites W2072370869 @default.
• W2892226813 cites W2073171113 @default.
• W2892226813 cites W2073934951 @default.
• W2892226813 cites W2074636483 @default.
• W2892226813 cites W2076590961 @default.
• W2892226813 cites W2078586062 @default.
• W2892226813 cites W2079344690 @default.
• W2892226813 cites W2085122311 @default.
• W2892226813 cites W2086115923 @default.
• W2892226813 cites W2086194193 @default.
• W2892226813 cites W2088193940 @default.
• W2892226813 cites W2098196189 @default.
• W2892226813 cites W2100897801 @default.
• W2892226813 cites W2110971703 @default.
• W2892226813 cites W2111265958 @default.
• W2892226813 cites W2113785887 @default.
• W2892226813 cites W2115301416 @default.
• W2892226813 cites W2116093245 @default.
• W2892226813 cites W2119974245 @default.
• W2892226813 cites W2140069482 @default.
• W2892226813 cites W2158299065 @default.
• W2892226813 cites W2164729929 @default.
• W2892226813 cites W2164840394 @default.
• W2892226813 cites W2272987617 @default.
• W2892226813 cites W2396327249 @default.
• W2892226813 cites W2415707997 @default.
• W2892226813 cites W2419128626 @default.
• W2892226813 cites W2510122802 @default.
• W2892226813 cites W2521995441 @default.
• W2892226813 cites W2523897893 @default.
• W2892226813 cites W2531877583 @default.
• W2892226813 cites W2560708839 @default.
• W2892226813 cites W2571452238 @default.
• W2892226813 cites W2586983911 @default.
• W2892226813 cites W2589794737 @default.
• W2892226813 cites W2606300381 @default.
• W2892226813 cites W2736483836 @default.
• W2892226813 cites W2738604006 @default.
• W2892226813 cites W2741110496 @default.
• W2892226813 cites W2790184058 @default.
• W2892226813 cites W2807143291 @default.
• W2892226813 cites W72549793 @default.
• W2892226813 cites W2134112603 @default.
• W2892226813 doi "https://doi.org/10.7717/peerj.5538" @default.
• W2892226813 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6129139" @default.
• W2892226813 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30202654" @default.
• W2892226813 hasPublicationYear "2018" @default.
• W2892226813 type Work @default.
• W2892226813 sameAs 2892226813 @default.
• W2892226813 citedByCount "13" @default.
• W2892226813 countsByYear W28922268132019 @default.

• next