FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892230172> ?p ?o ?g. }

• W2892230172 endingPage "6090" @default.
• W2892230172 startingPage "6081" @default.
• W2892230172 abstract "SNHG8 is identified as a key regulator in non-small-cell lung cancer progression sponging to miR-542-3p by targeting CCND1/CDK6 Changhao Chen,1,* Zhiwei Zhang,2,* Jie Li,3 Yuejun Sun4 1Department of General Surgery, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210003, China; 2Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China; 3Department of Respiratory Medicine, Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, Jiangsu 214400, China; 4Department of Pathology, Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, Jiangsu 214400, China *These authors contributed equally to this work Background: Recently, various dynamically expressed lncRNAs are known to play critical roles in cancer progression. Small nucleolar RNA host genes (SNHG), a stable cytoplasmic lncRNA, which have been widely reported to act as an oncogene in non-small cell lung cancer (NSCLC). As an important member of SNHG, SNHG8 have been suggested to over-expressed in several cancer disease, while the biological function in NSCLC remains unclear. Purpose: Here we investigated the biological function and underlying mechanism of SNHG8 in human NSCLC. Patients and methods: The relationship between SNHG8 expression and clinicopathologic characteristic in NSCLC patients were observed from January 2014 to December 2014 in 120 NSCLC patients. The expression of SNHG8 were analyzed by qRT-PCR assay in cancer tissues and cells. Cell proliferation ability were detected in NSCLC cells by CCK-8 assay. Flow cytometric analysis were performed to detected the cell apoptosis and cell cycle. Luciferase assay and Western blot assay were performed on NSCLC cells to detected the underlying mechanism of SNHG8 in NSCLC. Moreover, Tumor xenografts in nude mice were performed to detected the in vivo function of SNHG8. Results: SNHG8 was over-expressed in NSCLC tissues and cells. Patients with high SNHG8 expression have poorer overall survival (OS) and progression-free survival (PFS) than the patients with low SNHG8 expression. SNHG8 knockdown inhibited NSCLC cell proliferation in vitro and in vivo, arrested cell cycle in the G0/G1 phase via targeting miR-542-3p/CCND1/CDK6, and induced cell apoptosis via activation of Caspase-3. Conclusion: SNHG8 negatively regulated miR-542-3p in NSCLC progression by regulating downstream effectors including CCND1 and CDK6. SNHG8 showed great potential for the application in the treatment of NSCLC. Keywords: SNHG8, non-small-cell lung cancer, cell proliferation, miR-542-3p, CCND1/CDK6, Caspase-3, cell proliferation, therapeutic target" @default.
• W2892230172 created "2018-09-27" @default.
• W2892230172 creator A5013150562 @default.
• W2892230172 creator A5068252474 @default.
• W2892230172 creator A5074431495 @default.
• W2892230172 creator A5079851373 @default.
• W2892230172 date "2018-09-01" @default.
• W2892230172 modified "2023-10-12" @default.
• W2892230172 title "SNHG8 is identified as a key regulator in non-small-cell lung cancer progression sponging to miR-542-3p by targeting CCND1/CDK6" @default.
• W2892230172 cites W2004815615 @default.
• W2892230172 cites W2024078916 @default.
• W2892230172 cites W2029243859 @default.
• W2892230172 cites W2068206221 @default.
• W2892230172 cites W2110957978 @default.
• W2892230172 cites W2111119573 @default.
• W2892230172 cites W2117977572 @default.
• W2892230172 cites W2118008449 @default.
• W2892230172 cites W2129375421 @default.
• W2892230172 cites W2144330816 @default.
• W2892230172 cites W2148050145 @default.
• W2892230172 cites W2150098952 @default.
• W2892230172 cites W2153234291 @default.
• W2892230172 cites W2272984102 @default.
• W2892230172 cites W2296139876 @default.
• W2892230172 cites W2315898231 @default.
• W2892230172 cites W2465935653 @default.
• W2892230172 cites W2552492472 @default.
• W2892230172 cites W2580747910 @default.
• W2892230172 cites W2767667746 @default.
• W2892230172 cites W2781525129 @default.
• W2892230172 cites W3024528493 @default.
• W2892230172 cites W4238604577 @default.
• W2892230172 cites W964275744 @default.
• W2892230172 doi "https://doi.org/10.2147/ott.s170482" @default.
• W2892230172 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6158002" @default.
• W2892230172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30275712" @default.
• W2892230172 hasPublicationYear "2018" @default.
• W2892230172 type Work @default.
• W2892230172 sameAs 2892230172 @default.
• W2892230172 citedByCount "36" @default.
• W2892230172 countsByYear W28922301722018 @default.
• W2892230172 countsByYear W28922301722019 @default.
• W2892230172 countsByYear W28922301722020 @default.
• W2892230172 countsByYear W28922301722021 @default.
• W2892230172 countsByYear W28922301722022 @default.
• W2892230172 countsByYear W28922301722023 @default.
• W2892230172 crossrefType "journal-article" @default.
• W2892230172 hasAuthorship W2892230172A5013150562 @default.
• W2892230172 hasAuthorship W2892230172A5068252474 @default.
• W2892230172 hasAuthorship W2892230172A5074431495 @default.
• W2892230172 hasAuthorship W2892230172A5079851373 @default.
• W2892230172 hasBestOaLocation W28922301721 @default.
• W2892230172 hasConcept C104317684 @default.
• W2892230172 hasConcept C121608353 @default.
• W2892230172 hasConcept C126322002 @default.
• W2892230172 hasConcept C143998085 @default.
• W2892230172 hasConcept C145059251 @default.
• W2892230172 hasConcept C190283241 @default.
• W2892230172 hasConcept C199649820 @default.
• W2892230172 hasConcept C199835354 @default.
• W2892230172 hasConcept C2776256026 @default.
• W2892230172 hasConcept C2781018059 @default.
• W2892230172 hasConcept C29537977 @default.
• W2892230172 hasConcept C502942594 @default.
• W2892230172 hasConcept C54355233 @default.
• W2892230172 hasConcept C55493867 @default.
• W2892230172 hasConcept C62112901 @default.
• W2892230172 hasConcept C71924100 @default.
• W2892230172 hasConcept C86803240 @default.
• W2892230172 hasConceptScore W2892230172C104317684 @default.
• W2892230172 hasConceptScore W2892230172C121608353 @default.
• W2892230172 hasConceptScore W2892230172C126322002 @default.
• W2892230172 hasConceptScore W2892230172C143998085 @default.
• W2892230172 hasConceptScore W2892230172C145059251 @default.
• W2892230172 hasConceptScore W2892230172C190283241 @default.
• W2892230172 hasConceptScore W2892230172C199649820 @default.
• W2892230172 hasConceptScore W2892230172C199835354 @default.
• W2892230172 hasConceptScore W2892230172C2776256026 @default.
• W2892230172 hasConceptScore W2892230172C2781018059 @default.
• W2892230172 hasConceptScore W2892230172C29537977 @default.
• W2892230172 hasConceptScore W2892230172C502942594 @default.
• W2892230172 hasConceptScore W2892230172C54355233 @default.
• W2892230172 hasConceptScore W2892230172C55493867 @default.
• W2892230172 hasConceptScore W2892230172C62112901 @default.
• W2892230172 hasConceptScore W2892230172C71924100 @default.
• W2892230172 hasConceptScore W2892230172C86803240 @default.
• W2892230172 hasLocation W28922301721 @default.
• W2892230172 hasLocation W28922301722 @default.
• W2892230172 hasLocation W28922301723 @default.
• W2892230172 hasLocation W28922301724 @default.
• W2892230172 hasOpenAccess W2892230172 @default.
• W2892230172 hasPrimaryLocation W28922301721 @default.
• W2892230172 hasRelatedWork W1967180140 @default.
• W2892230172 hasRelatedWork W2586385055 @default.
• W2892230172 hasRelatedWork W2608904130 @default.
• W2892230172 hasRelatedWork W2609609327 @default.
• W2892230172 hasRelatedWork W2764038087 @default.
• W2892230172 hasRelatedWork W2765983506 @default.

• next