Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892232524> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2892232524 abstract "e20085 Background: Melanoma-associated antigen A1 (MAGE-A1) has been reported to perform oncogenically and act as an ideal candidate in tumor immunotherapy. Methods: One-step quantitative real-time polymerase chain reaction (qPCR) test and immunohistochemistry (IHC) analysis were used to detect the relationship between MAGE-A1 expression and the clinicopathological characteristics of lung adenocarcinoma (LAC). Then a novel MAGE-A1 IgG antibody was constructed on the previous MAGE-A1 scFv antibody by eukaryotic expression vectors. CCK-8, wound healing, transwell, matrigel, apoptosis, antibody-dependent cell-mediated cytotoxicity (ADCC) and CDC (complement-dependent cytotoxicity) assays were performed to evaluate the inhibitory effects of MAGE-A1-IgG on LAC in vitro. Results: High MAGE-A1 expression was observed in LAC tissues and MAGE-A1 expression was associated with several malignant properties of LAC patients, including overall survival. MAGE-A1-IgG revealed significant roles in inhibiting proliferation, inducing apoptosis and activating ADCC and CDC of LAC in a dose- and time- dependent manner in vitro. Conclusions: MAGE-A1-IgG may provide a promising therapeutic strategy for the treatment of MAGE-A1-positive LAC." @default.
- W2892232524 created "2018-09-27" @default.
- W2892232524 creator A5020951392 @default.
- W2892232524 creator A5036682412 @default.
- W2892232524 creator A5039663131 @default.
- W2892232524 creator A5042241049 @default.
- W2892232524 creator A5063344415 @default.
- W2892232524 creator A5063810304 @default.
- W2892232524 creator A5064444273 @default.
- W2892232524 creator A5080338192 @default.
- W2892232524 date "2017-05-20" @default.
- W2892232524 modified "2023-09-26" @default.
- W2892232524 title "A novel MAGE-A1-IgG antibody for lung adenocarcinoma." @default.
- W2892232524 doi "https://doi.org/10.1200/jco.2017.35.15_suppl.e20085" @default.
- W2892232524 hasPublicationYear "2017" @default.
- W2892232524 type Work @default.
- W2892232524 sameAs 2892232524 @default.
- W2892232524 citedByCount "1" @default.
- W2892232524 countsByYear W28922325242021 @default.
- W2892232524 crossrefType "journal-article" @default.
- W2892232524 hasAuthorship W2892232524A5020951392 @default.
- W2892232524 hasAuthorship W2892232524A5036682412 @default.
- W2892232524 hasAuthorship W2892232524A5039663131 @default.
- W2892232524 hasAuthorship W2892232524A5042241049 @default.
- W2892232524 hasAuthorship W2892232524A5063344415 @default.
- W2892232524 hasAuthorship W2892232524A5063810304 @default.
- W2892232524 hasAuthorship W2892232524A5064444273 @default.
- W2892232524 hasAuthorship W2892232524A5080338192 @default.
- W2892232524 hasConcept C121608353 @default.
- W2892232524 hasConcept C126322002 @default.
- W2892232524 hasConcept C143998085 @default.
- W2892232524 hasConcept C159654299 @default.
- W2892232524 hasConcept C203014093 @default.
- W2892232524 hasConcept C2776256026 @default.
- W2892232524 hasConcept C2781182431 @default.
- W2892232524 hasConcept C502942594 @default.
- W2892232524 hasConcept C71924100 @default.
- W2892232524 hasConceptScore W2892232524C121608353 @default.
- W2892232524 hasConceptScore W2892232524C126322002 @default.
- W2892232524 hasConceptScore W2892232524C143998085 @default.
- W2892232524 hasConceptScore W2892232524C159654299 @default.
- W2892232524 hasConceptScore W2892232524C203014093 @default.
- W2892232524 hasConceptScore W2892232524C2776256026 @default.
- W2892232524 hasConceptScore W2892232524C2781182431 @default.
- W2892232524 hasConceptScore W2892232524C502942594 @default.
- W2892232524 hasConceptScore W2892232524C71924100 @default.
- W2892232524 hasLocation W28922325241 @default.
- W2892232524 hasOpenAccess W2892232524 @default.
- W2892232524 hasPrimaryLocation W28922325241 @default.
- W2892232524 hasRelatedWork W1965504034 @default.
- W2892232524 hasRelatedWork W1974965248 @default.
- W2892232524 hasRelatedWork W1983109464 @default.
- W2892232524 hasRelatedWork W1994189198 @default.
- W2892232524 hasRelatedWork W1998426661 @default.
- W2892232524 hasRelatedWork W2012458858 @default.
- W2892232524 hasRelatedWork W2048931657 @default.
- W2892232524 hasRelatedWork W2131879910 @default.
- W2892232524 hasRelatedWork W2351229783 @default.
- W2892232524 hasRelatedWork W2376583768 @default.
- W2892232524 hasRelatedWork W2415034323 @default.
- W2892232524 hasRelatedWork W2587266711 @default.
- W2892232524 hasRelatedWork W2885676221 @default.
- W2892232524 hasRelatedWork W2982287108 @default.
- W2892232524 hasRelatedWork W3003761896 @default.
- W2892232524 hasRelatedWork W3030187827 @default.
- W2892232524 hasRelatedWork W3048126092 @default.
- W2892232524 hasRelatedWork W3093390692 @default.
- W2892232524 hasRelatedWork W2837476095 @default.
- W2892232524 hasRelatedWork W3166848722 @default.
- W2892232524 isParatext "false" @default.
- W2892232524 isRetracted "false" @default.
- W2892232524 magId "2892232524" @default.
- W2892232524 workType "article" @default.