FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892235723> ?p ?o ?g. }

• W2892235723 endingPage "S28" @default.
• W2892235723 startingPage "S27" @default.
• W2892235723 abstract "Background: Factor V is known to be a predictor of death in acute liver failure. However, it has never been tested as a predictor of death after LT. The aim of this study was to assess the role of plasmatic Factor V levels after LT as an predictor of mortality after LT. Methods: This retrospective study has assessed pateints that underwent LT between 2007 and 2017 at the Hospital de Clinicas de Porto Alegre, Brazil. All patients had measured plasmatic Factor V levels on the 2 nd postoperative day after LT. The Factor assay followed international standards. Early graft dysfunction (EGD) was defined by Olthoff et al. The primary outcome was overall mortality. The threshold for Factor V was stablished by ROC curve and Youden index. A multivariate analysis using Cox regression was performed to analyze the impact of Factor V in predicting death. Results: 225 patients were included in the study. The area under the ROC curve was 0.8. The sensitivity was and specificity to predict EGD was 72.3% and 72.9%, respectively. Patients with Factor V >43.65% were classified as High Factor V and ≤43.65% as Low Factor V. The Low Factor V group had 89 patients and the High Factor V group had 136 patients. Table 1 shows the demographic and clinical characteristics of patients. The proportion of patients diagnosed of EGD in the lower factor V group was 48% while it was 12% in the high Factor V group (p < 0.001). The median overall survival was 7.2 years for the high Factor V group vs. 5.9 years for the low Factor V group (p = 0.02). Factor V was an independent predictor for 6-months mortality [HR 0.96 (95%CI 0.94 – 0.98) and overall mortality [HR 0.98 (95% CI 0.97 – 0.99) after LT. Conclusion: Factor V may be an earlier predictor of mortality after LT. Further studies should be done to confirm these results and test Factor V relationship with other hepatic function markers.Tabled 1VariableLow Factor VHigh Factor VPN = 89N = 136Sex, male (%) Recipients59 (66.3)77 (56.6).09 Donors52 (58.4)80 (58.8).53Age, years (IQR) Recipients58 (48–61)57 (50–62).87 Donors37 (22–51)42 (23–55).38BMI donor, Kg/m2 (IQR)24.4 (22.8–26.4)25.4 (23.1–27.3).2HCV, yes (%)57 (64)99 (72.8).12HCC (%)43 (48.3)81 (59.5).06MELD score (IQR)14 (10–21)13 (10–18)0.09Donor cause of death.24 Cerebrovascular accident (%)41 (46.1)76 (55.9) Traumatic (%)40 (44.9)48 (35.3) Other (%)8 (9)12 (8.8)Cold ischemia time, min (IQR)450 (430–470)440 (424–480).33Warm ischemia time, min (IQR)35 (30–40)35 (30–40).27Surgical time, min (IQR)360 (288–432)315 (270–366).001Hepatic artery thrombosis (%)5 (5.6)7 (5.1).55EGD (%)43 (48.3)16 (11.8)<.001 Open table in a new tab" @default.
• W2892235723 created "2018-09-27" @default.
• W2892235723 creator A5000789082 @default.
• W2892235723 creator A5001054717 @default.
• W2892235723 creator A5003424521 @default.
• W2892235723 creator A5003543475 @default.
• W2892235723 creator A5004276657 @default.
• W2892235723 creator A5005164780 @default.
• W2892235723 creator A5028967174 @default.
• W2892235723 creator A5030785709 @default.
• W2892235723 creator A5054657490 @default.
• W2892235723 creator A5055111749 @default.
• W2892235723 creator A5058404286 @default.
• W2892235723 creator A5072319350 @default.
• W2892235723 date "2018-03-01" @default.
• W2892235723 modified "2023-09-27" @default.
• W2892235723 title "Serum factor V as a predictor of graft dysfunction and mortality after liver transplantation" @default.
• W2892235723 doi "https://doi.org/10.1016/j.hpb.2018.02.056" @default.
• W2892235723 hasPublicationYear "2018" @default.
• W2892235723 type Work @default.
• W2892235723 sameAs 2892235723 @default.
• W2892235723 citedByCount "1" @default.
• W2892235723 countsByYear W28922357232020 @default.
• W2892235723 crossrefType "journal-article" @default.
• W2892235723 hasAuthorship W2892235723A5000789082 @default.
• W2892235723 hasAuthorship W2892235723A5001054717 @default.
• W2892235723 hasAuthorship W2892235723A5003424521 @default.
• W2892235723 hasAuthorship W2892235723A5003543475 @default.
• W2892235723 hasAuthorship W2892235723A5004276657 @default.
• W2892235723 hasAuthorship W2892235723A5005164780 @default.
• W2892235723 hasAuthorship W2892235723A5028967174 @default.
• W2892235723 hasAuthorship W2892235723A5030785709 @default.
• W2892235723 hasAuthorship W2892235723A5054657490 @default.
• W2892235723 hasAuthorship W2892235723A5055111749 @default.
• W2892235723 hasAuthorship W2892235723A5058404286 @default.
• W2892235723 hasAuthorship W2892235723A5072319350 @default.
• W2892235723 hasBestOaLocation W28922357231 @default.
• W2892235723 hasConcept C126322002 @default.
• W2892235723 hasConcept C141071460 @default.
• W2892235723 hasConcept C167135981 @default.
• W2892235723 hasConcept C2779609443 @default.
• W2892235723 hasConcept C2911091166 @default.
• W2892235723 hasConcept C43346845 @default.
• W2892235723 hasConcept C50382708 @default.
• W2892235723 hasConcept C50440223 @default.
• W2892235723 hasConcept C58471807 @default.
• W2892235723 hasConcept C71924100 @default.
• W2892235723 hasConcept C90924648 @default.
• W2892235723 hasConceptScore W2892235723C126322002 @default.
• W2892235723 hasConceptScore W2892235723C141071460 @default.
• W2892235723 hasConceptScore W2892235723C167135981 @default.
• W2892235723 hasConceptScore W2892235723C2779609443 @default.
• W2892235723 hasConceptScore W2892235723C2911091166 @default.
• W2892235723 hasConceptScore W2892235723C43346845 @default.
• W2892235723 hasConceptScore W2892235723C50382708 @default.
• W2892235723 hasConceptScore W2892235723C50440223 @default.
• W2892235723 hasConceptScore W2892235723C58471807 @default.
• W2892235723 hasConceptScore W2892235723C71924100 @default.
• W2892235723 hasConceptScore W2892235723C90924648 @default.
• W2892235723 hasLocation W28922357231 @default.
• W2892235723 hasOpenAccess W2892235723 @default.
• W2892235723 hasPrimaryLocation W28922357231 @default.
• W2892235723 hasRelatedWork W1986441644 @default.
• W2892235723 hasRelatedWork W2047311193 @default.
• W2892235723 hasRelatedWork W2391586629 @default.
• W2892235723 hasRelatedWork W2913887538 @default.
• W2892235723 hasRelatedWork W2923613909 @default.
• W2892235723 hasRelatedWork W3031882306 @default.
• W2892235723 hasRelatedWork W3173904411 @default.
• W2892235723 hasRelatedWork W4280588610 @default.
• W2892235723 hasRelatedWork W4296290447 @default.
• W2892235723 hasRelatedWork W4320482681 @default.
• W2892235723 hasVolume "20" @default.
• W2892235723 isParatext "false" @default.
• W2892235723 isRetracted "false" @default.
• W2892235723 magId "2892235723" @default.
• W2892235723 workType "article" @default.