FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892235757> ?p ?o ?g. }

• W2892235757 endingPage "270" @default.
• W2892235757 startingPage "258" @default.
• W2892235757 abstract "<b><i>Background:</i></b> Infants born preterm following exposure to in utero inflammation/chorioamnionitis are at high risk of brain injury and life-long neurological deficits. In this study, we assessed the efficacy of early intervention umbilical cord blood (UCB) cell therapy in a large animal model of preterm brain inflammation and injury. We hypothesised that UCB treatment would be neuroprotective for the preterm brain following subclinical fetal inflammation. <b><i>Methods:</i></b> Chronically instrumented fetal sheep at 0.65 gestation were administered lipopolysaccharide (LPS, 150 ng, 055:B5) intravenously over 3 consecutive days, followed by 100 million human UCB mononuclear cells 6 h after the final LPS dose. Controls were administered saline instead of LPS and cells. Ten days after the first LPS dose, the fetal brain and cerebrospinal fluid were collected for analysis of subcortical and periventricular white matter injury and inflammation. <b><i>Results:</i></b> LPS administration increased microglial aggregate size, neutrophil recruitment, astrogliosis and cell death compared with controls. LPS also reduced total oligodendrocyte count and decreased mature myelinating oligodendrocytes. UCB cell therapy attenuated cell death and inflammation, and recovered total and mature oligodendrocytes, compared with LPS. <b><i>Conclusions:</i></b> UCB cell treatment following inflammation reduces preterm white matter brain injury, likely mediated via anti-inflammatory actions." @default.
• W2892235757 created "2018-09-27" @default.
• W2892235757 creator A5004184864 @default.
• W2892235757 creator A5007171963 @default.
• W2892235757 creator A5010262386 @default.
• W2892235757 creator A5013570044 @default.
• W2892235757 creator A5023962612 @default.
• W2892235757 creator A5027553318 @default.
• W2892235757 creator A5035521851 @default.
• W2892235757 creator A5059683473 @default.
• W2892235757 creator A5063001635 @default.
• W2892235757 creator A5073788859 @default.
• W2892235757 creator A5083955925 @default.
• W2892235757 creator A5085216803 @default.
• W2892235757 creator A5085710443 @default.
• W2892235757 date "2018-01-01" @default.
• W2892235757 modified "2023-10-10" @default.
• W2892235757 title "Human Umbilical Cord Blood Therapy Protects Cerebral White Matter from Systemic LPS Exposure in Preterm Fetal Sheep" @default.
• W2892235757 cites W1534465875 @default.
• W2892235757 cites W1583470249 @default.
• W2892235757 cites W1896545635 @default.
• W2892235757 cites W1914128451 @default.
• W2892235757 cites W1967486296 @default.
• W2892235757 cites W1972912243 @default.
• W2892235757 cites W1996684663 @default.
• W2892235757 cites W2001572086 @default.
• W2892235757 cites W2022438517 @default.
• W2892235757 cites W2026245311 @default.
• W2892235757 cites W2028535131 @default.
• W2892235757 cites W2033122192 @default.
• W2892235757 cites W2055176862 @default.
• W2892235757 cites W2055298628 @default.
• W2892235757 cites W2069668308 @default.
• W2892235757 cites W2069808350 @default.
• W2892235757 cites W2080762448 @default.
• W2892235757 cites W2081767587 @default.
• W2892235757 cites W2094617144 @default.
• W2892235757 cites W2094725377 @default.
• W2892235757 cites W2103589991 @default.
• W2892235757 cites W2112349803 @default.
• W2892235757 cites W2135776201 @default.
• W2892235757 cites W2147556339 @default.
• W2892235757 cites W2149932590 @default.
• W2892235757 cites W2150069228 @default.
• W2892235757 cites W2157799711 @default.
• W2892235757 cites W2162503073 @default.
• W2892235757 cites W2253473696 @default.
• W2892235757 cites W2416060637 @default.
• W2892235757 cites W2441591664 @default.
• W2892235757 cites W2557974023 @default.
• W2892235757 cites W2577181490 @default.
• W2892235757 cites W2580044575 @default.
• W2892235757 cites W2594929501 @default.
• W2892235757 cites W2599345944 @default.
• W2892235757 cites W2605179218 @default.
• W2892235757 cites W266500323 @default.
• W2892235757 cites W2759771152 @default.
• W2892235757 cites W2765978876 @default.
• W2892235757 cites W2769464088 @default.
• W2892235757 cites W2803793575 @default.
• W2892235757 cites W78578829 @default.
• W2892235757 cites W2478089842 @default.
• W2892235757 doi "https://doi.org/10.1159/000490943" @default.
• W2892235757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30179864" @default.
• W2892235757 hasPublicationYear "2018" @default.
• W2892235757 type Work @default.
• W2892235757 sameAs 2892235757 @default.
• W2892235757 citedByCount "35" @default.
• W2892235757 countsByYear W28922357572019 @default.
• W2892235757 countsByYear W28922357572020 @default.
• W2892235757 countsByYear W28922357572021 @default.
• W2892235757 countsByYear W28922357572022 @default.
• W2892235757 countsByYear W28922357572023 @default.
• W2892235757 crossrefType "journal-article" @default.
• W2892235757 hasAuthorship W2892235757A5004184864 @default.
• W2892235757 hasAuthorship W2892235757A5007171963 @default.
• W2892235757 hasAuthorship W2892235757A5010262386 @default.
• W2892235757 hasAuthorship W2892235757A5013570044 @default.
• W2892235757 hasAuthorship W2892235757A5023962612 @default.
• W2892235757 hasAuthorship W2892235757A5027553318 @default.
• W2892235757 hasAuthorship W2892235757A5035521851 @default.
• W2892235757 hasAuthorship W2892235757A5059683473 @default.
• W2892235757 hasAuthorship W2892235757A5063001635 @default.
• W2892235757 hasAuthorship W2892235757A5073788859 @default.
• W2892235757 hasAuthorship W2892235757A5083955925 @default.
• W2892235757 hasAuthorship W2892235757A5085216803 @default.
• W2892235757 hasAuthorship W2892235757A5085710443 @default.
• W2892235757 hasBestOaLocation W28922357571 @default.
• W2892235757 hasConcept C126322002 @default.
• W2892235757 hasConcept C126838900 @default.
• W2892235757 hasConcept C143409427 @default.
• W2892235757 hasConcept C172680121 @default.
• W2892235757 hasConcept C203014093 @default.
• W2892235757 hasConcept C25498285 @default.
• W2892235757 hasConcept C2776252253 @default.
• W2892235757 hasConcept C2776914184 @default.
• W2892235757 hasConcept C2776955114 @default.
• W2892235757 hasConcept C2777629866 @default.

• next