FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892236444> ?p ?o ?g. }

• W2892236444 endingPage "1367" @default.
• W2892236444 startingPage "1355" @default.
• W2892236444 abstract "Abstract Although the contractile function of the heart is universally conserved, the organ itself varies in structure across species. This variation includes the number of ventricular chambers (one, two, or an incompletely divided chamber), the structure of the myocardial wall (compact or trabeculated), and the proliferative capacity of the resident cardiomyocytes. Whereas zebrafish are capable of comparatively high rates of constitutive cardiomyocyte proliferation, humans and rodents are not. However, for most species, the capacity to generate new cardiomyocytes under homeostatic conditions remains unclear. Here, we investigate cardiomyocyte proliferation in the lizard Eublepharis macularius , the leopard gecko. As for other lizards, the leopard gecko heart has a partially septated ventricular lumen with a trabeculated myocardial wall. To test our hypothesis that leopard gecko cardiomyocytes routinely proliferate, we performed 5‐bromo‐2′‐deoxyuridine incorporation and immunostained for the mitotic marker phosphorylated histone H3 (pHH3) and the DNA synthesis phase (S phase) marker proliferating cell nuclear antigen (PCNA). Using double immunofluorescence, we co‐localized pHH3 or PCNA with the cardiomyocyte marker myosin heavy chain (MHC). We found that ~0.5% of cardiomyocytes were mitotically active (pHH3+/MHC+), while ~10% were in S phase (PCNA+/MHC+). We also determined that cell cycling by gecko cardiomyocytes is not impacted by caudal autotomy (tail loss), a dramatic form of self‐amputation. Finally, we show that populations of cardiac cells are slow cycling. Overall, our findings provide predictive evidence that geckos may be capable of spontaneous cardiac self‐repair and regeneration following a direct injury." @default.
• W2892236444 created "2018-09-27" @default.
• W2892236444 creator A5078090296 @default.
• W2892236444 creator A5090948337 @default.
• W2892236444 date "2018-09-01" @default.
• W2892236444 modified "2023-10-10" @default.
• W2892236444 title "Constitutive cardiomyocyte proliferation in the leopard gecko (<i>Eublepharis macularius</i>)" @default.
• W2892236444 cites W1669479280 @default.
• W2892236444 cites W1969038150 @default.
• W2892236444 cites W1981068608 @default.
• W2892236444 cites W1982815250 @default.
• W2892236444 cites W1996830761 @default.
• W2892236444 cites W1997581012 @default.
• W2892236444 cites W1998457769 @default.
• W2892236444 cites W2006505235 @default.
• W2892236444 cites W2007448592 @default.
• W2892236444 cites W2010368308 @default.
• W2892236444 cites W2012706299 @default.
• W2892236444 cites W2016835212 @default.
• W2892236444 cites W2016845287 @default.
• W2892236444 cites W2019778868 @default.
• W2892236444 cites W2028036560 @default.
• W2892236444 cites W2036896859 @default.
• W2892236444 cites W2045425000 @default.
• W2892236444 cites W2046754570 @default.
• W2892236444 cites W2048506716 @default.
• W2892236444 cites W2050844272 @default.
• W2892236444 cites W2054017195 @default.
• W2892236444 cites W2054673403 @default.
• W2892236444 cites W2068109108 @default.
• W2892236444 cites W2069389563 @default.
• W2892236444 cites W2072673889 @default.
• W2892236444 cites W2078443370 @default.
• W2892236444 cites W2083575511 @default.
• W2892236444 cites W2087453574 @default.
• W2892236444 cites W2091135325 @default.
• W2892236444 cites W2092036283 @default.
• W2892236444 cites W2093494581 @default.
• W2892236444 cites W2101678761 @default.
• W2892236444 cites W2101986300 @default.
• W2892236444 cites W2106809072 @default.
• W2892236444 cites W2112786856 @default.
• W2892236444 cites W2120760574 @default.
• W2892236444 cites W2124955671 @default.
• W2892236444 cites W2126747203 @default.
• W2892236444 cites W2134039588 @default.
• W2892236444 cites W2138447928 @default.
• W2892236444 cites W2138605163 @default.
• W2892236444 cites W2147908244 @default.
• W2892236444 cites W2154116722 @default.
• W2892236444 cites W2156067423 @default.
• W2892236444 cites W2168873824 @default.
• W2892236444 cites W2175263209 @default.
• W2892236444 cites W2225099229 @default.
• W2892236444 cites W2277824238 @default.
• W2892236444 cites W2342866781 @default.
• W2892236444 cites W2481237472 @default.
• W2892236444 cites W2741228895 @default.
• W2892236444 cites W2748256387 @default.
• W2892236444 cites W2753333414 @default.
• W2892236444 cites W2765473532 @default.
• W2892236444 cites W2789133580 @default.
• W2892236444 doi "https://doi.org/10.1002/jmor.20850" @default.
• W2892236444 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30221788" @default.
• W2892236444 hasPublicationYear "2018" @default.
• W2892236444 type Work @default.
• W2892236444 sameAs 2892236444 @default.
• W2892236444 citedByCount "11" @default.
• W2892236444 countsByYear W28922364442019 @default.
• W2892236444 countsByYear W28922364442020 @default.
• W2892236444 countsByYear W28922364442021 @default.
• W2892236444 countsByYear W28922364442022 @default.
• W2892236444 crossrefType "journal-article" @default.
• W2892236444 hasAuthorship W2892236444A5078090296 @default.
• W2892236444 hasAuthorship W2892236444A5090948337 @default.
• W2892236444 hasConcept C207200792 @default.
• W2892236444 hasConcept C34688535 @default.
• W2892236444 hasConcept C54355233 @default.
• W2892236444 hasConcept C62112901 @default.
• W2892236444 hasConcept C86803240 @default.
• W2892236444 hasConcept C93304396 @default.
• W2892236444 hasConcept C95444343 @default.
• W2892236444 hasConceptScore W2892236444C207200792 @default.
• W2892236444 hasConceptScore W2892236444C34688535 @default.
• W2892236444 hasConceptScore W2892236444C54355233 @default.
• W2892236444 hasConceptScore W2892236444C62112901 @default.
• W2892236444 hasConceptScore W2892236444C86803240 @default.
• W2892236444 hasConceptScore W2892236444C93304396 @default.
• W2892236444 hasConceptScore W2892236444C95444343 @default.
• W2892236444 hasFunder F4320334593 @default.
• W2892236444 hasIssue "9" @default.
• W2892236444 hasLocation W28922364441 @default.
• W2892236444 hasLocation W28922364442 @default.
• W2892236444 hasOpenAccess W2892236444 @default.
• W2892236444 hasPrimaryLocation W28922364441 @default.
• W2892236444 hasRelatedWork W1641042124 @default.
• W2892236444 hasRelatedWork W1990804418 @default.
• W2892236444 hasRelatedWork W1993764875 @default.

• next