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- W2892238172 abstract "SYNTHESIS AND KINETICS STUDIES OFALPHA-OXYMETHYL-ALPHA,BETA-CYCLOHEXENONES:Alan Andrew Wiles, Masterof Phylosophy, The University of Manchester, 2010This studydescribes a continuation of the investigation of analogues of theStreptomyces metabolite2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-tri-hydroxycyclohex-2-enone(COTC).In the first part, the synthesis of several analogues of thesimplified analogue of COTC,COMC is described. The results ofpreliminary kinetic studies as well as bio-assays ofthese compoundsagainst non-small cell lung cancer cell lines A549 and H460 isalsoreported. In the second part, efforts towards the synthesis ofan analogue of COTC,engineered to present a second electrophilicsite, is described, using readily availablechiral-pool startingmaterial (-)-quinic acid." @default.
- W2892238172 created "2018-09-27" @default.
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- W2892238172 date "2011-01-01" @default.
- W2892238172 modified "2023-09-27" @default.
- W2892238172 title "SYNTHESIS AND KINETICS STUDIES OFα-OXYMETHYL-α,β-CYCLOHEXENONES" @default.
- W2892238172 hasPublicationYear "2011" @default.
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