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- W2892261244 endingPage "630" @default.
- W2892261244 startingPage "608" @default.
- W2892261244 abstract "Alzheimer's disease (AD) is the most common (60% to 80%) age-related disease associated with dementia and is characterized by a deterioration of behavioral and cognitive capacities leading to death in few years after diagnosis, mainly due to complications from chronic illness. The characteristic hallmarks of the disease are extracellular senile plaques (SPs) and intracellular neurofibrillary tangles (NFTs) with neuropil threads, which are a direct result of amyloid precursor protein (APP) processing to Aβ, and τ hyperphosphorylation. However, many indirect underlying processes play a role in this event. One of these underlying mechanisms leading to these histological hallmarks is the uncontrolled hyperactivation of a family of cysteine proteases called calpains. Under normal physiological condition calpains participate in many processes of cells' life and their activation is tightly controlled. However, with an increase in age, increased oxidative stress and other excitotoxicity assaults, this regulatory system becomes impaired and result in increased activation of these proteases involving them in the pathogenesis of various diseases including neurodegeneration like AD. Reviewed here is a pool of data on the implication of calpains in the pathogenesis of AD, the underlying molecular mechanism, and the potential of targeting these enzymes for AD therapeutics." @default.
- W2892261244 created "2018-09-27" @default.
- W2892261244 creator A5002993192 @default.
- W2892261244 creator A5023079191 @default.
- W2892261244 creator A5027320261 @default.
- W2892261244 creator A5063945009 @default.
- W2892261244 creator A5071707212 @default.
- W2892261244 creator A5081143722 @default.
- W2892261244 date "2018-09-10" @default.
- W2892261244 modified "2023-10-14" @default.
- W2892261244 title "Involvement of calpain in the neuropathogenesis of Alzheimer’s disease" @default.
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