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- W2892267252 abstract "Work on synthetic biology has largely used a component-based metaphor for system construction. While this paradigm has been successful for the construction of numerous systems, the incorporation of contextual design issues-either compositional, host or environmental-will be key to realising more complex applications. Here, we present a design framework that radically steps away from a purely parts-based paradigm by using aspect-oriented software engineering concepts. We believe that the notion of concerns is a powerful and biologically credible way of thinking about system synthesis. By adopting this approach, we can separate core concerns, which represent modular aims of the design, from cross-cutting concerns, which represent system-wide attributes. The explicit handling of cross-cutting concerns allows for contextual information to enter the design process in a modular way. As a proof-of-principle, we implemented the aspect-oriented approach in the Python tool, SynBioWeaver, which enables the combination, or weaving, of core and cross-cutting concerns. The power and flexibility of this framework is demonstrated through a number of examples covering the inclusion of part context, combining circuit designs in a context dependent manner, and the generation of rule, logic and reaction models from synthetic circuit designs." @default.
- W2892267252 created "2018-09-27" @default.
- W2892267252 creator A5025029418 @default.
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- W2892267252 creator A5054223600 @default.
- W2892267252 creator A5073991203 @default.
- W2892267252 date "2018-09-15" @default.
- W2892267252 modified "2023-10-14" @default.
- W2892267252 title "Towards an Aspect-Oriented Design and Modelling Framework for Synthetic Biology" @default.
- W2892267252 cites W1645305843 @default.
- W2892267252 cites W1963204303 @default.
- W2892267252 cites W1966645118 @default.
- W2892267252 cites W1970422609 @default.
- W2892267252 cites W1970971896 @default.
- W2892267252 cites W1974028960 @default.
- W2892267252 cites W1979197349 @default.
- W2892267252 cites W1980348663 @default.
- W2892267252 cites W1982228455 @default.
- W2892267252 cites W1985161570 @default.
- W2892267252 cites W1985462363 @default.
- W2892267252 cites W1986649132 @default.
- W2892267252 cites W1988327779 @default.
- W2892267252 cites W1999679140 @default.
- W2892267252 cites W2001426985 @default.
- W2892267252 cites W2017298372 @default.
- W2892267252 cites W2019998456 @default.
- W2892267252 cites W2020684750 @default.
- W2892267252 cites W2026039411 @default.
- W2892267252 cites W2029370898 @default.
- W2892267252 cites W2037913229 @default.
- W2892267252 cites W2043151065 @default.
- W2892267252 cites W2047360542 @default.
- W2892267252 cites W2047882868 @default.
- W2892267252 cites W2058131374 @default.
- W2892267252 cites W2060184615 @default.
- W2892267252 cites W2065833295 @default.
- W2892267252 cites W2072391169 @default.
- W2892267252 cites W2076745068 @default.
- W2892267252 cites W2079136072 @default.
- W2892267252 cites W2081781433 @default.
- W2892267252 cites W2087234479 @default.
- W2892267252 cites W2087504899 @default.
- W2892267252 cites W2091239006 @default.
- W2892267252 cites W2091731123 @default.
- W2892267252 cites W2096492216 @default.
- W2892267252 cites W2097240335 @default.
- W2892267252 cites W2105662588 @default.
- W2892267252 cites W2115606218 @default.
- W2892267252 cites W2121806138 @default.
- W2892267252 cites W2124981936 @default.
- W2892267252 cites W2125615370 @default.
- W2892267252 cites W2132404641 @default.
- W2892267252 cites W2132724170 @default.
- W2892267252 cites W2132828256 @default.
- W2892267252 cites W2134221731 @default.
- W2892267252 cites W2134759932 @default.
- W2892267252 cites W2135141237 @default.
- W2892267252 cites W2135783707 @default.
- W2892267252 cites W2139129111 @default.
- W2892267252 cites W2149778176 @default.
- W2892267252 cites W2150281351 @default.
- W2892267252 cites W2150908245 @default.
- W2892267252 cites W2158274785 @default.
- W2892267252 cites W2158979830 @default.
- W2892267252 cites W2161783808 @default.
- W2892267252 cites W2166499263 @default.
- W2892267252 cites W2167879794 @default.
- W2892267252 cites W2168142693 @default.
- W2892267252 cites W2168517434 @default.
- W2892267252 cites W2169193349 @default.
- W2892267252 cites W2180674069 @default.
- W2892267252 cites W2316378629 @default.
- W2892267252 cites W2317656203 @default.
- W2892267252 cites W2320207021 @default.
- W2892267252 cites W2321347863 @default.
- W2892267252 cites W2323489435 @default.
- W2892267252 cites W2330245166 @default.
- W2892267252 cites W2335196113 @default.
- W2892267252 cites W2343741934 @default.
- W2892267252 cites W2535730799 @default.
- W2892267252 cites W2747801569 @default.
- W2892267252 cites W2767223603 @default.
- W2892267252 cites W2788004430 @default.
- W2892267252 cites W2793140738 @default.
- W2892267252 cites W2805850211 @default.
- W2892267252 cites W2806273582 @default.
- W2892267252 cites W2808812465 @default.
- W2892267252 cites W2811336659 @default.
- W2892267252 cites W2883421345 @default.
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- W2892267252 doi "https://doi.org/10.3390/pr6090167" @default.
- W2892267252 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6296438" @default.
- W2892267252 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30568914" @default.
- W2892267252 hasPublicationYear "2018" @default.
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