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• W2892267998 endingPage "79" @default.
• W2892267998 startingPage "68" @default.
• W2892267998 abstract "This literature review focuses on the primary morphological and structural characteristics, and mechanical properties identified in muscles affected by spastic cerebral palsy (CP). CP is a non-progressive neurological disorder caused by brain damage and is commonly diagnosed at birth. Although the brain damage is not progressive, subsequent neuro-physiological developmental adaptations may initiate changes in muscle structure, function, and composition, causing abnormal muscle activity and coordination. The symptoms of CP vary among patients. However, muscle spasticity is commonly present and is one of the most debilitating effects of CP. Here, we present the current knowledge regarding the mechanical properties of skeletal tissue affected by spastic CP. An increase in sarcomere length, collagen content, and fascicle diameter, and a reduction in the number of satellite cells within spastic CP muscle were consistent findings in the literature. Studies differed, however, in changes in fascicle lengths and fiber diameters. We also present a conceptual mechanical model of fascicle force transmission that incorporates mechanisms that impact both serial and lateral force production, highlighting the connections between the macro and micro structures of muscle to assist in deducing specific mechanisms for property changes and reduced force production." @default.
• W2892267998 created "2018-09-27" @default.
• W2892267998 creator A5013004495 @default.
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• W2892267998 date "2019-02-01" @default.
• W2892267998 modified "2023-09-26" @default.
• W2892267998 title "Skeletal Muscle Adaptations and Passive Muscle Stiffness in Cerebral Palsy: A Literature Review and Conceptual Model" @default.
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• W2892267998 doi "https://doi.org/10.1123/jab.2018-0049" @default.
• W2892267998 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30207207" @default.
• W2892267998 hasPublicationYear "2019" @default.
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