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- W2892269207 abstract "Apocynin (APO), a specific NADPH oxidase inhibitor, is a bioactive phytochemical that exhibits versatile pharmacological activities. However, its rapid elimination and poor bioavailability represent great challenges to pharmaceutical scientists. Accordingly, novel chitosan-based APO-loaded solid lipid nanoparticles (CS,APO - loaded SLNS) were developed to address such obstacles. A full 24 factorial design of experiment approach was employed to evaluate the individual and combined effect of critical process parameters namely; the amount of glycerol tristearate (GTS, XA) and sucrose mono palmitate (SMP, XB) as well as the concentration of chitosan (CS, XC) and polyvinyl alcohol (PVA, XD), on different critical quality attributes. Full characterization and extensive in vitro-in vivo evaluations of the optimized SLNs formula were conducted. The optimized formula, with core (CS,APO) and shell (PVA), has enhanced oral and intravenous bioavailability in rats as clearly verified when compared with APO solution. Probably, PVA hindered opsonization intravenously and SLNs reduced pre-systemic effect. In conclusion, the novel chitosan-based SLNs system would open new vistas in potentiating the bioavailability and sustaining the effect of APO and other bioactive phytochemicals with comparable properties." @default.
- W2892269207 created "2018-09-27" @default.
- W2892269207 creator A5035591604 @default.
- W2892269207 creator A5040615120 @default.
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- W2892269207 date "2018-11-01" @default.
- W2892269207 modified "2023-10-17" @default.
- W2892269207 title "Novel chitosan-based solid-lipid nanoparticles to enhance the bio-residence of the miraculous phytochemical “Apocynin”" @default.
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- W2892269207 doi "https://doi.org/10.1016/j.ejps.2018.09.001" @default.
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