Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892269884> ?p ?o ?g. }
- W2892269884 endingPage "160" @default.
- W2892269884 startingPage "154" @default.
- W2892269884 abstract "Rheumatoid arthritis (RA) is one of the most common autoimmune diseases. Th17 has been shown to play am important role in the pathogenesis of RA. Accumulating data suggest the involvement of NLRP3 inflammasome in Th17 differentiation in autoimmune diseases. In the current study, we found that NLRP3 inflammasome is activated in CD4 T cells from RA patients. The activation of NLRP3 inflammasome was correlated with disease activities and IL-17A concentration in RA sera. Knockdown of NLRP3 suppressed Th17 differentiation. In addition, caspase-1 or IL-1 receptor inhibitor inhibits Th17 differentiation significantly. Further, ROS production is increased in CD4 T cells from RA patients. The inhibition of ROS production decreased NLRP3 inflammasome activation and IL-1β production in CD4 T cells, leading to the suppression of Th17 differentiation. These findings suggest a pathogenic role of NLRP3 inflammasome in RA by promoting Th17 cell differentiation. NLRP3 inflammasome could be a potential therapeutic target for the treatment of RA." @default.
- W2892269884 created "2018-09-27" @default.
- W2892269884 creator A5006748743 @default.
- W2892269884 creator A5037677450 @default.
- W2892269884 creator A5051167739 @default.
- W2892269884 creator A5072052341 @default.
- W2892269884 date "2018-12-01" @default.
- W2892269884 modified "2023-09-30" @default.
- W2892269884 title "NLRP3 inflammasome regulates Th17 differentiation in rheumatoid arthritis" @default.
- W2892269884 cites W1528142849 @default.
- W2892269884 cites W1636698109 @default.
- W2892269884 cites W1918150899 @default.
- W2892269884 cites W1942500899 @default.
- W2892269884 cites W1969923705 @default.
- W2892269884 cites W1971915082 @default.
- W2892269884 cites W1976173775 @default.
- W2892269884 cites W1976926965 @default.
- W2892269884 cites W1978103379 @default.
- W2892269884 cites W1984344092 @default.
- W2892269884 cites W1993026721 @default.
- W2892269884 cites W2000084197 @default.
- W2892269884 cites W2005233485 @default.
- W2892269884 cites W2009435405 @default.
- W2892269884 cites W2029437196 @default.
- W2892269884 cites W2034032711 @default.
- W2892269884 cites W2048032544 @default.
- W2892269884 cites W2051713867 @default.
- W2892269884 cites W2058177171 @default.
- W2892269884 cites W2064282763 @default.
- W2892269884 cites W2085808988 @default.
- W2892269884 cites W2087402584 @default.
- W2892269884 cites W2093739574 @default.
- W2892269884 cites W2110826367 @default.
- W2892269884 cites W2127532898 @default.
- W2892269884 cites W2128952811 @default.
- W2892269884 cites W2136357996 @default.
- W2892269884 cites W2140637559 @default.
- W2892269884 cites W2153180469 @default.
- W2892269884 cites W2154362046 @default.
- W2892269884 cites W2155510706 @default.
- W2892269884 cites W2162836448 @default.
- W2892269884 cites W2165275387 @default.
- W2892269884 cites W2166209782 @default.
- W2892269884 cites W2313462881 @default.
- W2892269884 cites W2319457448 @default.
- W2892269884 cites W2337516302 @default.
- W2892269884 cites W2416699599 @default.
- W2892269884 cites W2751594739 @default.
- W2892269884 cites W4211217520 @default.
- W2892269884 doi "https://doi.org/10.1016/j.clim.2018.09.007" @default.
- W2892269884 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30236770" @default.
- W2892269884 hasPublicationYear "2018" @default.
- W2892269884 type Work @default.
- W2892269884 sameAs 2892269884 @default.
- W2892269884 citedByCount "58" @default.
- W2892269884 countsByYear W28922698842019 @default.
- W2892269884 countsByYear W28922698842020 @default.
- W2892269884 countsByYear W28922698842021 @default.
- W2892269884 countsByYear W28922698842022 @default.
- W2892269884 countsByYear W28922698842023 @default.
- W2892269884 crossrefType "journal-article" @default.
- W2892269884 hasAuthorship W2892269884A5006748743 @default.
- W2892269884 hasAuthorship W2892269884A5037677450 @default.
- W2892269884 hasAuthorship W2892269884A5051167739 @default.
- W2892269884 hasAuthorship W2892269884A5072052341 @default.
- W2892269884 hasConcept C104317684 @default.
- W2892269884 hasConcept C126322002 @default.
- W2892269884 hasConcept C148738053 @default.
- W2892269884 hasConcept C170493617 @default.
- W2892269884 hasConcept C173396325 @default.
- W2892269884 hasConcept C185592680 @default.
- W2892269884 hasConcept C190283241 @default.
- W2892269884 hasConcept C203014093 @default.
- W2892269884 hasConcept C2776914184 @default.
- W2892269884 hasConcept C2777077863 @default.
- W2892269884 hasConcept C2777209026 @default.
- W2892269884 hasConcept C2777575956 @default.
- W2892269884 hasConcept C2778690821 @default.
- W2892269884 hasConcept C2780942790 @default.
- W2892269884 hasConcept C47348012 @default.
- W2892269884 hasConcept C502942594 @default.
- W2892269884 hasConcept C55493867 @default.
- W2892269884 hasConcept C71924100 @default.
- W2892269884 hasConcept C86803240 @default.
- W2892269884 hasConcept C95444343 @default.
- W2892269884 hasConceptScore W2892269884C104317684 @default.
- W2892269884 hasConceptScore W2892269884C126322002 @default.
- W2892269884 hasConceptScore W2892269884C148738053 @default.
- W2892269884 hasConceptScore W2892269884C170493617 @default.
- W2892269884 hasConceptScore W2892269884C173396325 @default.
- W2892269884 hasConceptScore W2892269884C185592680 @default.
- W2892269884 hasConceptScore W2892269884C190283241 @default.
- W2892269884 hasConceptScore W2892269884C203014093 @default.
- W2892269884 hasConceptScore W2892269884C2776914184 @default.
- W2892269884 hasConceptScore W2892269884C2777077863 @default.
- W2892269884 hasConceptScore W2892269884C2777209026 @default.
- W2892269884 hasConceptScore W2892269884C2777575956 @default.
- W2892269884 hasConceptScore W2892269884C2778690821 @default.