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- W2892272978 abstract "The well-established herbicide, asulam (methy14-aminobenzenesulphonylcarbamate; MB 9% female) and also appears in faeces (4%). Induction of rats with asulam does not effect overall metabolism and excretion except that decarbamoylation is increased in the gut. N4-acetylsulphanilamide is also produced ( 2%) by decarbamoylation in the gut. N4-acetylasulam formation in vitro is located in the cell-membrane fraction of liver. Asulam is not eliminated in the bile (1% dose) in vivo. No binding spectrum is obtained with microsomal cytochrome P450. Continuous perfusion through liver for 6 hours does not increase biliary elimination, but at least three water-soluble unidentified compounds (4.5%) are formed in plasma. In contrast to the in vivo state asulam causes rapid oxygen uptake in vitro with microsomes producing an isolatable colored metabolite (max = 330 nm) which contains ring-substituted hydroxy sulphonamido and nitrogen substituted carbamate groups. Mass spectrometry shows this not to be 2-hydroxyasulam." @default.
- W2892272978 created "2018-09-27" @default.
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- W2892272978 date "1979-01-01" @default.
- W2892272978 modified "2023-09-23" @default.
- W2892272978 title "Metabolic studies on Asulam (M&B 9057)" @default.
- W2892272978 hasPublicationYear "1979" @default.
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