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- W2892274553 abstract "This study provides the discovery and validation of intervertebral disc degeneration (IDD) specific mRNA transcriptome profiles generated by NGS. We identified that insulin-like growth factor binding protein 5 (IGFBP5) was downregulated in human degenerative nucleus pulposus tissues and that its level was associated with the disc degeneration grade. In addition, the inhibitory effects of downregulated IGFBP5 are, in part, mediated through the ERK signaling pathway. Using in vivo and in vitro studies, functional characterization of the role of IGFBP5 revealed that the loss of its expression is an event in IDD pathogenesis. Therefore, strategies to maintain the expression or to prevent the repression of IGFBP5 have the potential to become a possible therapeutic and/or preventive approach for degenerative disc disease." @default.
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- W2892274553 date "2018-09-24" @default.
- W2892274553 modified "2023-10-16" @default.
- W2892274553 title "Downregulation of insulin-like growth factor binding protein 5 is involved in intervertebral disc degeneration via the ERK signaling pathway" @default.
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- W2892274553 doi "https://doi.org/10.1101/425272" @default.
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