Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892275487> ?p ?o ?g. }
- W2892275487 endingPage "55" @default.
- W2892275487 startingPage "47" @default.
- W2892275487 abstract "Prostate cancer (PCa) is the most common cancer and the 3rd leading cause of cancer-related deaths among men in the United States. Androgen-deprivation-therapy (ADT) with anti-androgens to target the androgens/androgen receptor (AR) signals remains the standard therapy for advanced PCa. However, most of the PCa patients who received ADT with anti-androgens, including the recently developed Enzalutamide (Enz) that might extend PCa patients survival an extra 4.8 months, will still develop the castration (or anti-androgen) resistance. Mechanism dissection studies suggest these anti-androgen resistances may involve the induction of AR splicing variants and/or AR mutants. Further preclinical in vitro/in vivo studies suggest ADT-anti-androgens may also enhance the neuroendocrine differentiation (NED) and PCa cell invasion, and these unwanted side-effects may function through various mechanisms including altering the infiltrating inflammatory cells within the prostate tumor microenvironment. This review summarizes these unwanted ADT-induced side-effects and discusses multiple approaches to overcome these side-effects to better suppress the PCa at the castration resistant stage." @default.
- W2892275487 created "2018-09-27" @default.
- W2892275487 creator A5010554321 @default.
- W2892275487 creator A5016024313 @default.
- W2892275487 creator A5021089842 @default.
- W2892275487 creator A5024338553 @default.
- W2892275487 creator A5029168436 @default.
- W2892275487 creator A5038615752 @default.
- W2892275487 creator A5041721692 @default.
- W2892275487 creator A5064286400 @default.
- W2892275487 creator A5076124157 @default.
- W2892275487 date "2018-12-01" @default.
- W2892275487 modified "2023-10-14" @default.
- W2892275487 title "ADT with antiandrogens in prostate cancer induces adverse effect of increasing resistance, neuroendocrine differentiation and tumor metastasis" @default.
- W2892275487 cites W1519682167 @default.
- W2892275487 cites W1882606371 @default.
- W2892275487 cites W1938050263 @default.
- W2892275487 cites W1965283193 @default.
- W2892275487 cites W1970700693 @default.
- W2892275487 cites W1971715644 @default.
- W2892275487 cites W1973442219 @default.
- W2892275487 cites W1974677050 @default.
- W2892275487 cites W1975042281 @default.
- W2892275487 cites W1976382352 @default.
- W2892275487 cites W1978441470 @default.
- W2892275487 cites W1987939948 @default.
- W2892275487 cites W2002372801 @default.
- W2892275487 cites W2003955264 @default.
- W2892275487 cites W2009607678 @default.
- W2892275487 cites W2010072924 @default.
- W2892275487 cites W2014556566 @default.
- W2892275487 cites W2017919614 @default.
- W2892275487 cites W2021497980 @default.
- W2892275487 cites W2023591758 @default.
- W2892275487 cites W2030161097 @default.
- W2892275487 cites W2033023549 @default.
- W2892275487 cites W2036274810 @default.
- W2892275487 cites W2037700362 @default.
- W2892275487 cites W2050602600 @default.
- W2892275487 cites W2051505294 @default.
- W2892275487 cites W2060559284 @default.
- W2892275487 cites W2061271065 @default.
- W2892275487 cites W2061541987 @default.
- W2892275487 cites W2062956430 @default.
- W2892275487 cites W2063870109 @default.
- W2892275487 cites W2064293531 @default.
- W2892275487 cites W2066570340 @default.
- W2892275487 cites W2066875072 @default.
- W2892275487 cites W2069802541 @default.
- W2892275487 cites W2073336624 @default.
- W2892275487 cites W2074369446 @default.
- W2892275487 cites W2079351077 @default.
- W2892275487 cites W2080134152 @default.
- W2892275487 cites W2080156485 @default.
- W2892275487 cites W2080748037 @default.
- W2892275487 cites W2083981959 @default.
- W2892275487 cites W2088339770 @default.
- W2892275487 cites W2094252220 @default.
- W2892275487 cites W2097121410 @default.
- W2892275487 cites W2097226696 @default.
- W2892275487 cites W2099480372 @default.
- W2892275487 cites W2107579122 @default.
- W2892275487 cites W2110534364 @default.
- W2892275487 cites W2118238803 @default.
- W2892275487 cites W2118428599 @default.
- W2892275487 cites W2119178036 @default.
- W2892275487 cites W2119504728 @default.
- W2892275487 cites W2121846636 @default.
- W2892275487 cites W2126812800 @default.
- W2892275487 cites W2129509993 @default.
- W2892275487 cites W2130189600 @default.
- W2892275487 cites W2131130559 @default.
- W2892275487 cites W2134555283 @default.
- W2892275487 cites W2134690947 @default.
- W2892275487 cites W2134988422 @default.
- W2892275487 cites W2135347498 @default.
- W2892275487 cites W2135468465 @default.
- W2892275487 cites W2137279230 @default.
- W2892275487 cites W2137467802 @default.
- W2892275487 cites W2140459477 @default.
- W2892275487 cites W2140675573 @default.
- W2892275487 cites W2147166694 @default.
- W2892275487 cites W2148643283 @default.
- W2892275487 cites W2149131962 @default.
- W2892275487 cites W2150609534 @default.
- W2892275487 cites W2151732765 @default.
- W2892275487 cites W2152211177 @default.
- W2892275487 cites W2152510711 @default.
- W2892275487 cites W2156923287 @default.
- W2892275487 cites W2157980218 @default.
- W2892275487 cites W2159959302 @default.
- W2892275487 cites W2160844431 @default.
- W2892275487 cites W2161879447 @default.
- W2892275487 cites W2166324735 @default.
- W2892275487 cites W2166918329 @default.
- W2892275487 cites W2167547884 @default.
- W2892275487 cites W2170810973 @default.
- W2892275487 cites W2170874144 @default.