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- W2892275496 abstract "UGTs play crucial roles in the metabolism and detoxification of both endogenous and xenobiotic compounds. The key roles of UGTs in human health have garnered great interest in the design and development of specific probes for human UGTs. However, in contrast to other human enzymes, the probe substrates for human UGTs are rarely reported, owing to the highly overlapping substrate specificities of UGTs and the lack of the integrated crystal structures of UGTs. Over the past decades, many efforts are made to develop specific probe substrates for UGTs and use them in both basic research and drug discovery. This review focuses on recent progress in the development of probe substrates for UGTs and their biomedical applications. A long list of chemical probes for UGTs, including non‐fluorescent and fluorescent probes along with their structural information and kinetic parameters, are prepared and analyzed. Additionally, challenges and future directions in this field are highlighted in the final section. All information and knowledge presented in this review provide practical tools/methods for measuring UGT activities in complex biological samples, which will be very helpful for rapid screening and characterization of UGT modulators, and for exploring the relevance of UGT enzymes to human diseases." @default.
- W2892275496 created "2018-09-27" @default.
- W2892275496 creator A5004775159 @default.
- W2892275496 creator A5021739084 @default.
- W2892275496 creator A5022288937 @default.
- W2892275496 creator A5022495891 @default.
- W2892275496 creator A5041758601 @default.
- W2892275496 creator A5050920786 @default.
- W2892275496 creator A5085353674 @default.
- W2892275496 date "2018-09-27" @default.
- W2892275496 modified "2023-10-15" @default.
- W2892275496 title "Chemical Probes for Human UDP-Glucuronosyltransferases: A Comprehensive Review" @default.
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